PI3Kγ inhibition drives M1 macrophage differentiation and synergizes with PD-L1 blockade to improve survival in poorly immunogenic head and neck squamous cell carcinoma
PI3Kγ抑制剂可促进M1型巨噬细胞分化,并与PD-L1阻断剂协同作用,提高免疫原性较差的头颈部鳞状细胞癌患者的生存率。
期刊:Cancer Biology & Therapy
影响因子:4.6
doi:10.1080/15384047.2025.2600701
Jordanides, Pete P; Jagadeesha, Sushmitha; Upadhaya, Puja; Ryan, Nathan M; Anderson, Kelvin; Lamenza, Felipe F; Shrestha, Suvekshya; Siddiqui, Arham; Bopp, Anna R; Pracha, Sherefuddin H; Roth, Peyton; Kehres, Reegan; Mo, Xiaokui; Oghumu, Steve
巨噬细胞
肿瘤
肿瘤免疫
巨噬细胞
PD-L1
细胞生物学
免疫/内分泌