日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanistic insights into the therapeutic properties of delta opioid receptor

对δ阿片受体治疗特性的机制性见解

Bernhard, Sarah M; Roy Chowdhury, Susovan; Murata, Tsuyoshi; Reinl, Erin L; Ramos-Gonzalez, Nokomis; Denn, Elizabeth; Appourchaux, Kevin; Inoue, Asuka; England, Sarah K; Fay, Jonathan F; Majumdar, Susruta; Chanda, Baron; Che, Tao

Divergence in μ and δ opioid receptor pharmacology in neurons and antinociceptive efficacy in neuropathic pain: Insights from MP135 and CYM51010

神经元中μ和δ阿片受体药理学的差异以及神经性疼痛的镇痛功效:来自MP135和CYM51010的启示

Inquimbert, Perrine; Fitterer, Chantal; Hugel, Sylvain; Jesic, Mila; Goumon, Yannick; Andry, Virgine; Schneider, Severine; Daubeuf, Francois; Faouzi, Abdelfattah; Doridot, Stephane; Majumdar, Susruta; Bihel, Frederic; Schmitt, Martine; Massotte, Dominique

Characterization of Novel Sigma Receptor Ligands Derived from Multicomponent Reactions as Efficacious Treatments for Neuropathic Pain

表征源自多组分反应的新型σ受体配体作为治疗神经性疼痛的有效方法

Shinouchi, Ryosuke; Turgutalp, Bengisu; Ople, Rohini S; Eans, Shainnel O; Williams, Ashai K; Hammond, Haylee R; Varadi, Andras; Dardashti, Rebecca Notis; Majumdar, Susruta; McLaughlin, Jay P

Discovery and dynamic pharmacology of μ-opioid receptor positive allosteric modulators

μ-阿片受体正向变构调节剂的发现和动态药理学

O'Brien, Evan S; Wang, Junzheng; Tanguturi, Parthasaradhireddy; Li, Mengchu; White, Elizabeth; Shiimura, Yuki; Paul, Barnali; Appourchaux, Kevin; Kumar, Kaavya Krishna; Huang, Weijiao; Majumdar, Susruta; Traynor, John R; Streicher, John M; Chen, Chunlai; Kobilka, Brian K

A cryptic pocket in CB1 drives peripheral and functional selectivity

CB1 中的一个隐蔽口袋驱动外周和功能选择性

Rangari, Vipin Ashok; O'Brien, Evan S; Powers, Alexander S; Slivicki, Richard A; Bertels, Zachariah; Appourchaux, Kevin; Aydin, Deniz; Ramos-Gonzalez, Nokomis; Mwirigi, Juliet; Lin, Li; Mangutov, Elizaveta; Sobecks, Briana L; Awad-Agbaria, Yaseen; Uphade, Manoj B; Aguilar, Jhoan; Peddada, Teja Nikhil; Shiimura, Yuki; Huang, Xi-Ping; Folarin-Hines, Jakayla; Payne, Maria; Kalathil, Anirudh; Varga, Balazs R; Kobilka, Brian K; Pradhan, Amynah A; Cameron, Michael D; Kumar, Kaavya Krishna; Dror, Ron O; Gereau, Robert W 4th; Majumdar, Susruta

Advances in the structural understanding of opioid allostery

阿片类药物变构结构理解的进展

Ramos-Gonzalez, Nokomis; Varga, Balazs R; Majumdar, Susruta

Genomic landscape of diffuse glioma revealed by whole genome sequencing

全基因组测序揭示弥漫性胶质瘤的基因组图谱

Kinnersley, Ben; Jung, Josephine; Cornish, Alex J; Chubb, Daniel; Laxton, Ross; Frangou, Anna; Gruber, Andreas J; Sud, Amit; Caravagna, Giulio; Sottoriva, Andrea; Wedge, David C; Booth, Thomas; Al-Sarraj, Safa; Lawrence, Samuel E D; Albanese, Erminia; Anichini, Giulio; Baxter, David; Boukas, Alexandros; Chowdhury, Yasir A; D'Urso, Pietro; Corns, Robert; Dapaah, Andrew; Edlmann, Ellie; Greenway, Fay; Grundy, Paul; Hill, Ciaran S; Jenkinson, Michael D; Trichinopoly Krishna, Sandhya; Smith, Stuart; Manivannan, Susruta; Martin, Andrew J; Matloob, Samir; Mukherjee, Soumya; O'Neill, Kevin; Plaha, Puneet; Pollock, Jonathan; Price, Stephen; Rominiyi, Ola; Sachdev, Bobby; Saeed, Fozia; Sinha, Saurabh; Thorne, Lewis; Ughratdar, Ismail; Whitfield, Peter; Youshani, Amir Saam; Bulbeck, Helen; Arumugam, Prabhu; Houlston, Richard; Ashkan, Keyoumars

Structure-guided design of partial agonists at an opioid receptor.

基于结构的阿片受体部分激动剂设计

Varga Balazs R, Bernhard Sarah M, El Daibani Amal, Zaidi Saheem A, Lam Jordy H, Aguilar Jhoan, Appourchaux Kevin, Nazarova Antonina L, Kouvelis Alexa, Shinouchi Ryosuke, Hammond Haylee R, Eans Shainnel O, Weinreb Violetta, Margolis Elyssa B, Fay Jonathan F, Huang Xi-Ping, Pradhan Amynah, Katritch Vsevolod, McLaughlin Jay P, Majumdar Susruta, Che Tao

Molecular mechanisms of inverse agonism via κ-opioid receptor-G protein complexes.

通过α-阿片受体-G蛋白复合物的反向激动作用的分子机制

Tyson Aaliyah S, Khan Saif, Motiwala Zenia, Han Gye Won, Zhang Zixin, Ranjbar Mohsen, Styrpejko Daniel, Ramos-Gonzalez Nokomis, Woo Stone, Villers Kelly, Landaker Delainey, Kenakin Terry, Shenvi Ryan, Majumdar Susruta, Gati Cornelius

Total synthesis and biological activity of "carbamorphine": O-to-CH(2) replacement in the E-ring of the morphine core structure.

“卡巴吗啡”的全合成及生物活性:吗啡核心结构E环中的O-到-CH(2)取代

Akiyama Sota, Ople Rohini S, Kremsmair Alexander, Ramos-Gonzalez Nokomis, Nedungadan Thomas, Kennedy Brandon J, Appourchaux Kevin, Eans Shainnel O, Tsai Bowen A, Kraml Christina, Huang Xi-Ping, McLaughlin Jay P, Majumdar Susruta, Sarpong Richmond