文献库，生知库 | 链接生命科学的每一步

Efficacy of 42-month oral administration of glucoraphanin in preventing cognitive decline in individuals at elevated risk of dementia, including those with mild cognitive impairment: a randomized, double-blind, placebo-controlled pilot study

一项随机、双盲、安慰剂对照的试点研究：口服萝卜硫素42个月预防痴呆高危人群（包括轻度认知障碍患者）认知能力下降的疗效

doi:10.3389/fnut.2026.1740494

Shimizu, Sunao; Kasai, Shuya; Suzuki, Chieko; Kon, Tomoya; Suganuma, Hiroyuki; Suzuki, Shigenori; Murashita, Koichi; Nakaji, Shigeyuki; Ihara, Kazushige; Tomiyama, Masahiko; Itoh, Ken

神经科学

发表日期：2026

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Electrophysiological diagnosis using the coefficient of variation of R-R intervals and a point-of-care nerve conduction device is highly correlated to the diagnosis of diabetic polyneuropathy using conventional electromyographs

利用 RR 间期变异系数和床旁神经传导设备进行的电生理诊断与使用传统肌电图诊断糖尿病性多发性神经病具有高度相关性。

期刊:Journal of Diabetes Investigation

影响因子:3

doi:10.1111/jdi.70190

Himeno, Tatsuhito; Kamiya, Hideki; Shibata, Yuka; Kase, Masato; Nakai-Shimoda, Hiromi; Yamagami, Dai; Saito, Masahiro; Jojima, Teruo; Arimura, Aiko; Murotani, Kenta; Suzuki, Chieko; Mizukami, Hiroki; Deguchi, Takahisa; Aso, Yoshimasa; Nakamura, Jiro

Sleep Hours, Wake-Up Time, Bedtime, Breakfast Skipping, and Japanese-Style Diet (Staple Food, Main Dish, and Side Dish): A Cross-Sectional Study of Schoolchildren in Saga Prefecture

佐贺县学龄儿童睡眠时长、起床时间、就寝时间、是否吃早餐以及日式饮食（主食、主菜和配菜）：一项横断面研究

期刊:Children-Basel

影响因子:2.1

doi:10.3390/children13010030

Sato, Aya; Sato, Yuki; Suzuki, Chieko; Suzuki, Reiko

发表日期：2025

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A Novel Index Including Age, Sex, hTERT, and Methylated RUNX3 Is Useful for Diagnosing Early Gastric Cancer

一种包含年龄、性别、hTERT 和甲基化 RUNX3 的新型指标可用于早期胃癌的诊断

期刊:Oncology

影响因子:1.8

doi:10.1159/000541173

Nakamura, Katsuhiko; Suehiro, Yutaka; Hamabe, Koichi; Goto, Atsushi; Hashimoto, Shinichi; Kunimune, Yuki; Ishiguro, Akiyo; Okayama, Naoko; Fujii, Tomohiro; Nakahara, Yukiko; Nishioka, Mitsuaki; Higaki, Shingo; Fujii, Ikuei; Suzuki, Chieko; Nishikawa, Jun; Sakaida, Isao; Takami, Taro; Yamasaki, Takahiro

Sporadic Creutzfeldt-Jakob Disease Complicated by Intracerebral Hemorrhaging in the Early Stage of Onset

散发型克雅氏病早期并发脑出血

期刊:Internal Medicine

影响因子:1.1

doi:10.2169/internalmedicine.5229-24

Fujita, Masako; Nishijima, Haruo; Mikami, Youhei; Suzuki, Chieko; Tomiyama, Masahiko

神经科学

发表日期：2025

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Improved Assessment of Juxtacortical Lesions in Multiple Sclerosis Using Highly-accelerated High-resolution Double Inversion Recovery MR Imaging with Deep Learning-based Reconstruction

利用基于深度学习重建的高加速高分辨率双反转恢复磁共振成像技术改进多发性硬化症皮质下病变的评估

期刊:

影响因子:

doi:10.2463/mrms.mp.2024-0126

Shintaku, Tomohiro; Ide, Satoru; Nagaya, Haruka; Ishimoto, Yuka; Watanabe, Keita; Oyu, Kazuhiko; Kasai, Sera; Umemura, Yoshihito; Sasaki, Miho; Saito, Kana; Ozawa, Amo; Nozaki, Atsushi; Zhu, Xucheng; Wakayama, Tetsuya; Nishijima, Haruo; Suzuki, Chieko; Tomiyama, Masahiko; Kakeda, Shingo

Combination Assay of Methylated HOXA1 with Tumor Markers Shows High Sensitivity for Detection of Early-Stage Hepatocellular Carcinoma

HOXA1甲基化与肿瘤标志物联合检测对早期肝细胞癌的检测具有高灵敏度

期刊:Liver Cancer

影响因子:9.1

doi:10.1159/000536211

Kunimune, Yuki; Suehiro, Yutaka; Saeki, Issei; Yamauchi, Yurika; Tanabe, Norikazu; Matsumoto, Toshihiko; Higaki, Shingo; Fujii, Ikuei; Suzuki, Chieko; Okayama, Naoko; Nishioka, Mitsuaki; Ichihara, Kiyoshi; Nagano, Hiroaki; Sakaida, Isao; Takami, Taro; Yamasaki, Takahiro

A novel index combining fecal immunochemical test, DNA test, and age improves detection of advanced colorectal adenoma.

结合粪便免疫化学测试、DNA测试和年龄的新型指标提高了对晚期结直肠腺瘤的检测率

期刊:Cancer Science

影响因子:4.3

doi:10.1111/cas.16322

Inoue Yukari, Ishiguro Akiyo, Suehiro Yutaka, Kunimune Yuki, Yamaoka Yuko, Hashimoto Shinichi, Nakamura Katsuhiko, Goto Atsushi, Hamabe Koichi, Matsumoto Toshihiko, Tomochika Shinobu, Higaki Shingo, Fujii Ikuei, Suzuki Chieko, Koga Michiko, Tsutsumi Takeya, Lim Lay Ahyoung, Matsubara Yasuo, Yotsuyanagi Hiroshi, Nagano Hiroaki, Yamamoto Naoki, Sakaida Isao, Takami Taro, Nishioka Mitsuaki, Yamasaki Takahiro

Case report: Early-onset Parkinson's disease with lower limb spasticity in a new DJ-1/PARK7 patient

病例报告：一例新发DJ-1/PARK7患者出现早发性帕金森病伴下肢痉挛

期刊:Frontiers in Neuroscience

影响因子:3.2

doi:10.3389/fnins.2024.1400001

Fujita, Masako; Nishijima, Haruo; Katagai, Atsuko; Suzuki, Chieko; Hattori, Nobutaka; Tomiyama, Masahiko

Morphological Changes in Direct Pathway Striatal Neurons in a Rat Model of Tardive Dyskinesia

迟发性运动障碍大鼠模型中直接通路纹状体神经元的形态学变化

Efficacy of 42-month oral administration of glucoraphanin in preventing cognitive decline in individuals at elevated risk of dementia, including those with mild cognitive impairment: a randomized, double-blind, placebo-controlled pilot study

一项随机、双盲、安慰剂对照的试点研究：口服萝卜硫素42个月预防痴呆高危人群（包括轻度认知障碍患者）认知能力下降的疗效

Electrophysiological diagnosis using the coefficient of variation of R-R intervals and a point-of-care nerve conduction device is highly correlated to the diagnosis of diabetic polyneuropathy using conventional electromyographs

利用 RR 间期变异系数和床旁神经传导设备进行的电生理诊断与使用传统肌电图诊断糖尿病性多发性神经病具有高度相关性。

Sleep Hours, Wake-Up Time, Bedtime, Breakfast Skipping, and Japanese-Style Diet (Staple Food, Main Dish, and Side Dish): A Cross-Sectional Study of Schoolchildren in Saga Prefecture

佐贺县学龄儿童睡眠时长、起床时间、就寝时间、是否吃早餐以及日式饮食（主食、主菜和配菜）：一项横断面研究

A Novel Index Including Age, Sex, hTERT, and Methylated RUNX3 Is Useful for Diagnosing Early Gastric Cancer

一种包含年龄、性别、hTERT 和甲基化 RUNX3 的新型指标可用于早期胃癌的诊断

Sporadic Creutzfeldt-Jakob Disease Complicated by Intracerebral Hemorrhaging in the Early Stage of Onset

散发型克雅氏病早期并发脑出血

Improved Assessment of Juxtacortical Lesions in Multiple Sclerosis Using Highly-accelerated High-resolution Double Inversion Recovery MR Imaging with Deep Learning-based Reconstruction

利用基于深度学习重建的高加速高分辨率双反转恢复磁共振成像技术改进多发性硬化症皮质下病变的评估

Combination Assay of Methylated HOXA1 with Tumor Markers Shows High Sensitivity for Detection of Early-Stage Hepatocellular Carcinoma

HOXA1甲基化与肿瘤标志物联合检测对早期肝细胞癌的检测具有高灵敏度

A novel index combining fecal immunochemical test, DNA test, and age improves detection of advanced colorectal adenoma.

结合粪便免疫化学测试、DNA测试和年龄的新型指标提高了对晚期结直肠腺瘤的检测率

Case report: Early-onset Parkinson's disease with lower limb spasticity in a new DJ-1/PARK7 patient

病例报告：一例新发DJ-1/PARK7患者出现早发性帕金森病伴下肢痉挛