日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Loss of a newly discovered microRNA in Chinese hamster ovary cells leads to upregulation of N-glycolylneuraminic acid sialylation on monoclonal antibodies

中国仓鼠卵巢细胞中新发现的 microRNA 的丢失导致单克隆抗体上 N-乙醇酰神经氨酰唾液酸化的上调

Simon Fischer, Sven Mathias, Anna Stadermann, Shumin Yang, Valerie Schmieder, Nikolas Zeh, Nicoletta Schmidt, Patrick Richter, Sara Wright, Eike Zimmermann, Yan Ley, Julia van der Meer, Thomas Hartsch, Christian Bernloehr, Kerstin Otte, Harald Bradl, Martin Gamer, Patrick Schulz

Unveiling the CHO surfaceome: Identification of cell surface proteins reveals cell aggregation-relevant mechanisms

揭开 CHO 表面组学的面纱:鉴定细胞表面蛋白可揭示细胞聚集相关机制

Florian Klingler, Sven Mathias, Helga Schneider, Theresa Buck, Nadja Raab, Nikolas Zeh, Yu-Wei Shieh, Jens Pfannstiel, Kerstin Otte

Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain

单克隆抗体的合理优化可改善聚集倾向并增强整个制药工艺链中的 CMC 特性

Joschka Bauer, Sven Mathias, Sebastian Kube, Kerstin Otte, Patrick Garidel, Martin Gamer, Michaela Blech, Simon Fischer, Anne R Karow-Zwick

Unraveling what makes a monoclonal antibody difficult-to-express: From intracellular accumulation to incomplete folding and degradation via ERAD

揭示单克隆抗体难以表达的原因:从细胞内积累到不完全折叠和通过 ERAD 降解

Sven Mathias, Anna Wippermann, Nadja Raab, Nikolas Zeh, René Handrick, Ingo Gorr, Patrick Schulz, Simon Fischer, Martin Gamer, Kerstin Otte

Human CAP cells represent a novel source for functional, miRNA-loaded exosome production

人类 CAP 细胞是生产功能性、载有 miRNA 的外泌体的新来源

Nikolas Zeh, Helga Schneider, Sven Mathias, Nadja Raab, Michael Kleemann, Sabine Schmidt-Hertel, Benjamin Weis, Silke Wissing, Nikola Strempel, René Handrick, Kerstin Otte

Visualisation of intracellular production bottlenecks in suspension-adapted CHO cells producing complex biopharmaceuticals using fluorescence microscopy

使用荧光显微镜可视化悬浮适应型 CHO 细胞生产复杂生物制药时的细胞内生产瓶颈

Sven Mathias, Simon Fischer, René Handrick, Jürgen Fieder, Patrick Schulz, Harald Bradl, Ingo Gorr, Martin Gamer, Kerstin Otte