日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

一项包含超过25.4万名东亚和欧洲后裔的精细定位分析,鉴定出136个推定的结直肠癌易感基因。

Chen, Zhishan; Guo, Xingyi; Tao, Ran; Huyghe, Jeroen R; Law, Philip J; Fernandez-Rozadilla, Ceres; Ping, Jie; Jia, Guochong; Long, Jirong; Li, Chao; Shen, Quanhu; Xie, Yuhan; Timofeeva, Maria N; Thomas, Minta; Schmit, Stephanie L; Díez-Obrero, Virginia; Devall, Matthew; Moratalla-Navarro, Ferran; Fernandez-Tajes, Juan; Palles, Claire; Sherwood, Kitty; Briggs, Sarah E W; Svinti, Victoria; Donnelly, Kevin; Farrington, Susan M; Blackmur, James; Vaughan-Shaw, Peter G; Shu, Xiao-Ou; Lu, Yingchang; Broderick, Peter; Studd, James; Harrison, Tabitha A; Conti, David V; Schumacher, Fredrick R; Melas, Marilena; Rennert, Gad; Obón-Santacana, Mireia; Martín-Sánchez, Vicente; Oh, Jae Hwan; Kim, Jeongseon; Jee, Sun Ha; Jung, Keum Ji; Kweon, Sun-Seog; Shin, Min-Ho; Shin, Aesun; Ahn, Yoon-Ok; Kim, Dong-Hyun; Oze, Isao; Wen, Wanqing; Matsuo, Keitaro; Matsuda, Koichi; Tanikawa, Chizu; Ren, Zefang; Gao, Yu-Tang; Jia, Wei-Hua; Hopper, John L; Jenkins, Mark A; Win, Aung Ko; Pai, Rish K; Figueiredo, Jane C; Haile, Robert W; Gallinger, Steven; Woods, Michael O; Newcomb, Polly A; Duggan, David; Cheadle, Jeremy P; Kaplan, Richard; Kerr, Rachel; Kerr, David; Kirac, Iva; Böhm, Jan; Mecklin, Jukka-Pekka; Jousilahti, Pekka; Knekt, Paul; Aaltonen, Lauri A; Rissanen, Harri; Pukkala, Eero; Eriksson, Johan G; Cajuso, Tatiana; Hänninen, Ulrika; Kondelin, Johanna; Palin, Kimmo; Tanskanen, Tomas; Renkonen-Sinisalo, Laura; Männistö, Satu; Albanes, Demetrius; Weinstein, Stephanie J; Ruiz-Narvaez, Edward; Palmer, Julie R; Buchanan, Daniel D; Platz, Elizabeth A; Visvanathan, Kala; Ulrich, Cornelia M; Siegel, Erin; Brezina, Stefanie; Gsur, Andrea; Campbell, Peter T; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Slattery, Martha L; Potter, John D; Tsilidis, Kostas K; Schulze, Matthias B; Gunter, Marc J; Murphy, Neil; Castells, Antoni; Castellví-Bel, Sergi; Moreira, Leticia; Arndt, Volker; Shcherbina, Anna; Bishop, D Timothy; Giles, Graham G; Southey, Melissa C; Idos, Gregory E; McDonnell, Kevin J; Abu-Ful, Zomoroda; Greenson, Joel K; Shulman, Katerina; Lejbkowicz, Flavio; Offit, Kenneth; Su, Yu-Ru; Steinfelder, Robert; Keku, Temitope O; van Guelpen, Bethany; Hudson, Thomas J; Hampel, Heather; Pearlman, Rachel; Berndt, Sonja I; Hayes, Richard B; Martinez, Marie Elena; Thomas, Sushma S; Pharoah, Paul D P; Larsson, Susanna C; Yen, Yun; Lenz, Heinz-Josef; White, Emily; Li, Li; Doheny, Kimberly F; Pugh, Elizabeth; Shelford, Tameka; Chan, Andrew T; Cruz-Correa, Marcia; Lindblom, Annika; Hunter, David J; Joshi, Amit D; Schafmayer, Clemens; Scacheri, Peter C; Kundaje, Anshul; Schoen, Robert E; Hampe, Jochen; Stadler, Zsofia K; Vodicka, Pavel; Vodickova, Ludmila; Vymetalkova, Veronika; Edlund, Christopher K; Gauderman, W James; Shibata, David; Toland, Amanda; Markowitz, Sanford; Kim, Andre; Chanock, Stephen J; van Duijnhoven, Franzel; Feskens, Edith J M; Sakoda, Lori C; Gago-Dominguez, Manuela; Wolk, Alicja; Pardini, Barbara; FitzGerald, Liesel M; Lee, Soo Chin; Ogino, Shuji; Bien, Stephanie A; Kooperberg, Charles; Li, Christopher I; Lin, Yi; Prentice, Ross; Qu, Conghui; Bézieau, Stéphane; Yamaji, Taiki; Sawada, Norie; Iwasaki, Motoki; Le Marchand, Loic; Wu, Anna H; Qu, Chenxu; McNeil, Caroline E; Coetzee, Gerhard; Hayward, Caroline; Deary, Ian J; Harris, Sarah E; Theodoratou, Evropi; Reid, Stuart; Walker, Marion; Ooi, Li Yin; Lau, Ken S; Zhao, Hongyu; Hsu, Li; Cai, Qiuyin; Dunlop, Malcolm G; Gruber, Stephen B; Houlston, Richard S; Moreno, Victor; Casey, Graham; Peters, Ulrike; Tomlinson, Ian; Zheng, Wei

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

通过对100204例欧洲和东亚血统的结直肠癌患者和154587例对照者进行多组学分析,揭示结直肠癌的遗传学特征

Fernandez-Rozadilla, Ceres; Timofeeva, Maria; Chen, Zhishan; Law, Philip; Thomas, Minta; Schmit, Stephanie; Díez-Obrero, Virginia; Hsu, Li; Fernandez-Tajes, Juan; Palles, Claire; Sherwood, Kitty; Briggs, Sarah; Svinti, Victoria; Donnelly, Kevin; Farrington, Susan; Blackmur, James; Vaughan-Shaw, Peter; Shu, Xiao-Ou; Long, Jirong; Cai, Qiuyin; Guo, Xingyi; Lu, Yingchang; Broderick, Peter; Studd, James; Huyghe, Jeroen; Harrison, Tabitha; Conti, David; Dampier, Christopher; Devall, Mathew; Schumacher, Fredrick; Melas, Marilena; Rennert, Gad; Obón-Santacana, Mireia; Martín-Sánchez, Vicente; Moratalla-Navarro, Ferran; Oh, Jae Hwan; Kim, Jeongseon; Jee, Sun Ha; Jung, Keum Ji; Kweon, Sun-Seog; Shin, Min-Ho; Shin, Aesun; Ahn, Yoon-Ok; Kim, Dong-Hyun; Oze, Isao; Wen, Wanqing; Matsuo, Keitaro; Matsuda, Koichi; Tanikawa, Chizu; Ren, Zefang; Gao, Yu-Tang; Jia, Wei-Hua; Hopper, John; Jenkins, Mark; Win, Aung Ko; Pai, Rish; Figueiredo, Jane; Haile, Robert; Gallinger, Steven; Woods, Michael; Newcomb, Polly; Duggan, David; Cheadle, Jeremy; Kaplan, Richard; Maughan, Timothy; Kerr, Rachel; Kerr, David; Kirac, Iva; Böhm, Jan; Mecklin, Lukka-Pekka; Jousilahti, Pekka; Knekt, Paul; Aaltonen, Lauri; Rissanen, Harri; Pukkala, Eero; Eriksson, Johan; Cajuso, Tatiana; Hänninen, Ulrika; Kondelin, Johanna; Palin, Kimmo; Tanskanen, Tomas; Renkonen-Sinisalo, Laura; Zanke, Brent; Männistö, Satu; Albanes, Demetrius; Weinstein, Stephanie; Ruiz-Narvaez, Edward; Palmer, Julie; Buchanan, Daniel; Platz, Elizabeth; Visvanathan, Kala; Ulrich, Cornelia; Siegel, Erin; Brezina, Stefanie; Gsur, Andrea; Campbell, Peter; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Slattery, Martha; Potter, John; Tsilidis, Konstantinos; Schulze, Matthias; Gunter, Marc; Murphy, Neil; Castells, Antoni; Castellví-Bel, Sergi; Moreira, Leticia; Arndt, Volker; Shcherbina, Anna; Stern, Mariana; Pardamean, Bens; Bishop, Timothy; Giles, Graham; Southey, Melissa; Idos, Gregory; McDonnell, Kevin; Abu-Ful, Zomoroda; Greenson, Joel; Shulman, Katerina; Lejbkowicz, Flavio; Offit, Kenneth; Su, Yu-Ru; Steinfelder, Robert; Keku, Temitope; van Guelpen, Bethany; Hudson, Thomas; Hampel, Heather; Pearlman, Rachel; Berndt, Sonja; Hayes, Richard; Martinez, Marie Elena; Thomas, Sushma; Corley, Douglas; Pharoah, Paul; Larsson, Susanna; Yen, Yun; Lenz, Heinz-Josef; White, Emily; Li, Li; Doheny, Kimberly; Pugh, Elizabeth; Shelford, Tameka; Chan, Andrew; Cruz-Correa, Marcia; Lindblom, Annika; Hunter, David; Joshi, Amit; Schafmayer, Clemens; Scacheri, Peter; Kundaje, Anshul; Nickerson, Deborah; Schoen, Robert; Hampe, Jochen; Stadler, Zsofia; Vodicka, Pavel; Vodickova, Ludmila; Vymetalkova, Veronika; Papadopoulos, Nickolas; Edlund, Chistopher; Gauderman, William; Thomas, Duncan; Shibata, David; Toland, Amanda; Markowitz, Sanford; Kim, Andre; Chanock, Stephen; van Duijnhoven, Franzel; Feskens, Edith; Sakoda, Lori; Gago-Dominguez, Manuela; Wolk, Alicja; Naccarati, Alessio; Pardini, Barbara; FitzGerald, Liesel; Lee, Soo Chin; Ogino, Shuji; Bien, Stephanie; Kooperberg, Charles; Li, Christopher; Lin, Yi; Prentice, Ross; Qu, Conghui; Bézieau, Stéphane; Tangen, Catherine; Mardis, Elaine; Yamaji, Taiki; Sawada, Norie; Iwasaki, Motoki; Haiman, Christopher; Le Marchand, Loic; Wu, Anna; Qu, Chenxu; McNeil, Caroline; Coetzee, Gerhard; Hayward, Caroline; Deary, Ian; Harris, Sarah; Theodoratou, Evropi; Reid, Stuart; Walker, Marion; Ooi, Li Yin; Moreno, Victor; Casey, Graham; Gruber, Stephen; Tomlinson, Ian; Zheng, Wei; Dunlop, Malcolm; Houlston, Richard; Peters, Ulrike

Oral vitamin D supplementation induces transcriptomic changes in rectal mucosa that are linked to anti-tumour effects

口服维生素D补充剂可诱导直肠黏膜转录组发生改变,而这些改变与抗肿瘤作用相关。

Vaughan-Shaw, P G; Grimes, G; Blackmur, J P; Timofeeva, M; Walker, M; Ooi, L Y; Svinti, Victoria; Donnelly, Kevin; Din, F V N; Farrington, S M; Dunlop, M G

Colorectal cancer risk variants rs10161980 and rs7495132 are associated with cancer survival outcome by a recessive mode of inheritance

结直肠癌风险变异rs10161980和rs7495132与癌症生存结果相关,其遗传方式为隐性遗传

He, Yazhou; Timofeeva, Maria; Zhang, Xiaomeng; Xu, Wei; Li, Xue; Din, Farhat V N; Svinti, Victoria; Farrington, Susan M; Campbell, Harry; Dunlop, Malcolm G; Theodoratou, Evropi

Gene Co-Expression Network Analysis Identifies Vitamin D-Associated Gene Modules in Adult Normal Rectal Epithelium Following Supplementation

基因共表达网络分析鉴定出补充维生素D后成人正常直肠上皮细胞中与维生素D相关的基因模块

Blackmur, James P; Vaughan-Shaw, Peter G; Donnelly, Kevin; Harris, Bradley T; Svinti, Victoria; Ochocka-Fox, Anna-Maria; Freile, Paz; Walker, Marion; Gurran, Toby; Reid, Stuart; Semple, Colin A; Din, Farhat V N; Timofeeva, Maria; Dunlop, Malcolm G; Farrington, Susan M

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

关联分析发现了31个新的结直肠癌易感风险位点

Law, Philip J; Timofeeva, Maria; Fernandez-Rozadilla, Ceres; Broderick, Peter; Studd, James; Fernandez-Tajes, Juan; Farrington, Susan; Svinti, Victoria; Palles, Claire; Orlando, Giulia; Sud, Amit; Holroyd, Amy; Penegar, Steven; Theodoratou, Evropi; Vaughan-Shaw, Peter; Campbell, Harry; Zgaga, Lina; Hayward, Caroline; Campbell, Archie; Harris, Sarah; Deary, Ian J; Starr, John; Gatcombe, Laura; Pinna, Maria; Briggs, Sarah; Martin, Lynn; Jaeger, Emma; Sharma-Oates, Archana; East, James; Leedham, Simon; Arnold, Roland; Johnstone, Elaine; Wang, Haitao; Kerr, David; Kerr, Rachel; Maughan, Tim; Kaplan, Richard; Al-Tassan, Nada; Palin, Kimmo; Hänninen, Ulrika A; Cajuso, Tatiana; Tanskanen, Tomas; Kondelin, Johanna; Kaasinen, Eevi; Sarin, Antti-Pekka; Eriksson, Johan G; Rissanen, Harri; Knekt, Paul; Pukkala, Eero; Jousilahti, Pekka; Salomaa, Veikko; Ripatti, Samuli; Palotie, Aarno; Renkonen-Sinisalo, Laura; Lepistö, Anna; Böhm, Jan; Mecklin, Jukka-Pekka; Buchanan, Daniel D; Win, Aung-Ko; Hopper, John; Jenkins, Mark E; Lindor, Noralane M; Newcomb, Polly A; Gallinger, Steven; Duggan, David; Casey, Graham; Hoffmann, Per; Nöthen, Markus M; Jöckel, Karl-Heinz; Easton, Douglas F; Pharoah, Paul D P; Peto, Julian; Canzian, Federico; Swerdlow, Anthony; Eeles, Rosalind A; Kote-Jarai, Zsofia; Muir, Kenneth; Pashayan, Nora; Harkin, Andrea; Allan, Karen; McQueen, John; Paul, James; Iveson, Timothy; Saunders, Mark; Butterbach, Katja; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Kirac, Iva; Matošević, Petar; Hofer, Philipp; Brezina, Stefanie; Gsur, Andrea; Cheadle, Jeremy P; Aaltonen, Lauri A; Tomlinson, Ian; Houlston, Richard S; Dunlop, Malcolm G

Effects of common genetic variants associated with colorectal cancer risk on survival outcomes after diagnosis: A large population-based cohort study

常见遗传变异与结直肠癌风险相关对诊断后生存结局的影响:一项基于大型人群的队列研究

He, Yazhou; Theodoratou, Evropi; Li, Xue; Din, Farhat V N; Vaughan-Shaw, Peter; Svinti, Victoria; Farrington, Susan M; Campbell, Harry; Dunlop, Malcolm G; Timofeeva, Maria

A Comprehensive Study of the Effect on Colorectal Cancer Survival of Common Germline Genetic Variation Previously Linked with Cancer Prognosis

一项关于先前与癌症预后相关的常见种系遗传变异对结直肠癌生存率影响的综合研究

He, Yazhou; Timofeeva, Maria; Li, Xue; Din, Farhat V N; Blackmur, James P; Vaughan-Shaw, Peter; Svinti, Victoria; Farrington, Susan M; Campbell, Harry; Dunlop, Malcolm G; Theodoratou, Evropi

Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study

探索循环 25-羟基维生素 D 与结直肠癌风险之间关联的因果关系:一项大型孟德尔随机化研究

He, Yazhou; Timofeeva, Maria; Farrington, Susan M; Vaughan-Shaw, Peter; Svinti, Victoria; Walker, Marion; Zgaga, Lina; Meng, Xiangrui; Li, Xue; Spiliopoulou, Athina; Jiang, Xia; Hyppönen, Elina; Kraft, Peter; Kiel, Douglas P; Hayward, Caroline; Campbell, Archie; Porteous, David; Vucic, Katarina; Kirac, Iva; Filipovic, Masa; Harris, Sarah E; Deary, Ian J; Houlston, Richard; Tomlinson, Ian P; Campbell, Harry; Theodoratou, Evropi; Dunlop, Malcolm G

Genome-wide scan of the effect of common nsSNPs on colorectal cancer survival outcome

全基因组扫描常见非同义单核苷酸多态性(nsSNP)对结直肠癌生存结果的影响

Theodoratou, Evropi; Farrington, Susan M; Timofeeva, Maria; Din, Farhat Vn; Svinti, Victoria; Tenesa, Albert; Liu, Tao; Lindblom, Annika; Gallinger, Steven; Campbell, Harry; Dunlop, Malcolm G