日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The oncogene SLC35F2 is a high-specificity transporter for the micronutrients queuine and queuosine

癌基因SLC35F2是一种对微量营养素queuine和queuosine具有高特异性的转运蛋白。

Burtnyak, Lyubomyr; Yuan, Yifeng; Stojek, Erwina; Pan, Xiaobei; Gunaratne, Lankani; Silveira d'Almeida, Gabriel; Fergus, Claire; Martinelli, Maria; J Reed, Colbie; Fernandez, Jessie; Patel, Bhargesh Indravadan; Marquez, Isaac; Ehrenhofer-Murray, Ann E; Swairjo, Manal A; Alfonzo, Juan D; Green, Brian D; Kelly, Vincent P; de Crécy-Lagard, Valérie

Limitations of current machine learning models in predicting enzymatic functions for uncharacterized proteins

当前机器学习模型在预测未表征蛋白质的酶功能方面的局限性

de Crécy-Lagard, Valérie; Dias, Raquel; Sexson, Nick; Friedberg, Iddo; Yuan, Yifeng; Swairjo, Manal A

Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate

Qng1 介导从 5'-单磷酸奎宁中挽救微量营养素奎宁的结构基础

Shr-Hau Hung, Gregory I Elliott, Thakku R Ramkumar, Lyubomyr Burtnyak, Callum J McGrenaghan, Sana Alkuzweny, Samia Quaiyum, Dirk Iwata-Reuyl, Xiaobei Pan, Brian D Green, Vincent P Kelly, Valérie de Crécy-Lagard, Manal A Swairjo

7-Deazaguanines in DNA: functional and structural elucidation of a DNA modification system

DNA中的7-脱氮鸟嘌呤:DNA修饰系统的功能和结构阐明

Gedara, Samanthi Herath; Wood, Evan; Gustafson, Andrew; Liang, Cui; Hung, Shr-Hau; Savage, Joshua; Phan, Phuc; Luthra, Amit; de Crécy-Lagard, Valérie; Dedon, Peter; Swairjo, Manal A; Iwata-Reuyl, Dirk

Predicting the capsid architecture of phages from metagenomic data

利用宏基因组数据预测噬菌体的衣壳结构

Lee, Diana Y; Bartels, Caitlin; McNair, Katelyn; Edwards, Robert A; Swairjo, Manal A; Luque, Antoni

Detection of preQ0 deazaguanine modifications in bacteriophage CAjan DNA using Nanopore sequencing reveals same hypermodification at two distinct DNA motifs

利用纳米孔测序技术检测噬菌体 CAjan DNA 中的 preQ0 脱氮鸟嘌呤修饰,发现两种不同的 DNA 基序上存在相同的超修饰。

Kot, Witold; Olsen, Nikoline S; Nielsen, Tue K; Hutinet, Geoffrey; de Crécy-Lagard, Valérie; Cui, Liang; Dedon, Peter C; Carstens, Alexander B; Moineau, Sylvain; Swairjo, Manal A; Hansen, Lars H

Specificity in the biosynthesis of the universal tRNA nucleoside N6-threonylcarbamoyl adenosine (t6A)-TsaD is the gatekeeper

通用 tRNA 核苷 N6-苏氨酰氨基甲酰腺苷 (t6A)-TsaD 的生物合成特异性是守门人

William Swinehart, Christopher Deutsch, Kathryn L Sarachan, Amit Luthra, Jo Marie Bacusmo, Valérie de Crécy-Lagard, Manal A Swairjo, Paul F Agris, Dirk Iwata-Reuyl

Structure-based design of guanosine analogue inhibitors targeting GTP cyclohydrolase IB towards a new class of antibiotics

基于结构的鸟苷类似物抑制剂设计,靶向GTP环化水解酶IB,旨在开发一类新型抗生素

Samaan, George N; Paranagama, Naduni; Haque, Ayesha; Hecht, David A; Swairjo, Manal A; Purse, Byron W

Conformational communication mediates the reset step in t6A biosynthesis

构象通讯介导了t6A生物合成中的重置步骤。

Luthra, Amit; Paranagama, Naduni; Swinehart, William; Bayooz, Susan; Phan, Phuc; Quach, Vanessa; Schiffer, Jamie M; Stec, Boguslaw; Iwata-Reuyl, Dirk; Swairjo, Manal A

Discovery of novel bacterial queuine salvage enzymes and pathways in human pathogens

在人类病原体中发现新的细菌队列挽救酶和途径

Yifeng Yuan, Rémi Zallot, Tyler L Grove, Daniel J Payan, Isabelle Martin-Verstraete, Sara Šepić, Seetharamsingh Balamkundu, Ramesh Neelakandan, Vinod K Gadi, Chuan-Fa Liu, Manal A Swairjo, Peter C Dedon, Steven C Almo, John A Gerlt, Valérie de Crécy-Lagard3