日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.

利用 iPSC 衍生神经元进行 CRISPR 筛选揭示了 tau 蛋白稳态的原理。

Samelson Avi J, Ariqat Nabeela, McKetney Justin, Rohanitazangi Gita, Parra Bravo Celeste, Bose Rudra S, Travaglini Kyle J, Lam Victor L, Goodness Darrin, Ta Thomas, Dixon Gary, Marzette Emily, Jin Julianne, Tian Ruilin, Tse Eric, Abskharon Romany, Pan Henry S, Carroll Emma C, Lawrence Rosalie E, Gestwicki Jason E, Rexach Jessica E, Eisenberg David S, Kanaan Nicholas M, Southworth Daniel R, Gross John D, Gan Li, Swaney Danielle L, Kampmann Martin

Extracellular matrix proteolysis maintains synapse plasticity during brain development

细胞外基质蛋白水解在脑发育过程中维持突触可塑性

Nakajo, Haruna; Cao, Ran; Mula, Supriya A; McKetney, Justin; Silva, Nicholas J; Li, Kathy H; Chalkley, Robert J; Randolph, Lisa K; Shah, Muskaan; Rose, Indigo V L; Kampmann, Martin; Swaney, Danielle L; Kirst, Christoph; Molofsky, Anna V

Central control of dynamic gene circuits governs T cell rest and activation

动态基因回路的中央调控控制着T细胞的静息和激活。

Maya M Arce ,Jennifer M Umhoefer ,Nadia Arang ,Sivakanthan Kasinathan ,Jacob W Freimer ,Zachary Steinhart ,Haolin Shen ,Minh T N Pham ,Mineto Ota ,Anika Wadhera ,Rama Dajani ,Dmytro Dorovskyi ,Yan Yi Chen ,Qi Liu ,Yuan Zhou ,Danielle L Swaney ,Kirsten Obernier ,Brian R Shy ,Julia Carnevale ,Ansuman T Satpathy ,Nevan J Krogan ,Jonathan K Pritchard ,Alexander Marson

Selective RNA sequestration in biomolecular condensates directs cell fate transitions

生物分子凝聚体中RNA的选择性隔离决定细胞命运的转变

Pessina, Patrizia; Nevo, Mika; Shi, Junchao; Kodali, Srikanth; Casas, Eduard; Cui, Yingzhi; Richards, Alicia L; Park, Emily J; Chen, Xi; Levin-Ferreyra, Florencia; Rivera Tostado, Alejandra; Stevenson, Erica; Krogan, Nevan J; Swaney, Danielle L; Ying, Qilong; Chen, Qi; Brumbaugh, Justin; Di Stefano, Bruno

HBV Remodels PP2A Complexes to Rewire Kinase Signaling in Hepatocellular Carcinoma.

HBV通过重塑PP2A复合物来重新连接肝细胞癌中的激酶信号通路

Turnham Rigney E, Pitea Adriana, Jang Gwendolyn M, Xu Zhong, Lim Huat Chye, Choi Alex L, Von Dollen John, Levin Rebecca S, Webber James T, McCarthy Elizabeth, Hu Junjie, Li Xiaolei, Che Li, Singh Ananya, Yoon Alex, Chan Gary K L, Kelley Robin K, Swaney Danielle L, Zhang Wei, Bandyopadhyay Sourav, Theis Fabian J, Eckhardt Manon, Chen Xin, Shokat Kevan M, Ideker Trey, Krogan Nevan J, Gordan John D

Anti-restriction functions of injected phage proteins revealed by peeling back layers of bacterial immunity.

通过层层剥开细菌免疫屏障,揭示了注射噬菌体蛋白的抗限制功能

Silas Sukrit, Carion Héloïse, Makarova Kira S, Sanchez Godinez David, Haniyur Surabhi, Volino Lucy, Yee Wearn-Xin, Fossati Andrea, Swaney Danielle, Bocek Michael, Koonin Eugene V, Bondy-Denomy Joseph

Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction.

溶酶体蛋白质组学揭示了神经元 APOE4 相关溶酶体功能障碍的机制。

Krogsaeter Einar K, McKetney Justin, Valiente-Banuet Leopoldo, Marquez Angelica, Willis Alexandra, Cakir Zeynep, Stevenson Erica, Jang Gwendolyn M, Rao Antara, Li Emmy, Zhou Anton, Attili Anjani, Chang Timothy S, Kampmann Martin, Huang Yadong, Krogan Nevan J, Swaney Danielle L

EGFR and EGFRvIII coopt host defense pathways promoting progression in glioblastoma.

EGFR 和 EGFRvIII 利用宿主防御通路促进胶质母细胞瘤的进展

An Zhenyi, Fan Qi-Wen, Wang Linyu, Yoda Hiroyuki, Barata Megumi J, Jimenez-Morales David, Phillips Joanna J, Swaney Danielle L, Stevenson Erica, Lee Ethan, Krogan Nevan, Weiss William A

Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy

基于结构的、具有高效体内疗效的高生物利用度、共价、广谱冠状病毒MPro抑制剂的发现

Tyler C Detomasi ,Gilles Degotte ,Sijie Huang ,Rahul K Suryawanshi ,Amy Diallo ,Luca Lizzadro ,Francisco J Zapatero-Belinchón ,Taha Y Taha ,Jiapeng Li ,Alicia L Richards ,Eric R Hantz ,Zain Alam ,Mauricio Montano ,Maria McCavitt-Malvido ,Rajesh Gumpena ,James R Partridge ,Galen J Correy ,Yusuke Matsui ,Annemarie F Charvat ,Isabella S Glenn ,Julia Rosecrans ,Jezrael L Revalde ,Dashiell Anderson ,Judd F Hultquist ,Michelle R Arkin ,R Jeffrey Neitz ,Danielle L Swaney ,Nevan J Krogan ,Brian K Shoichet ,Kliment A Verba ,Melanie Ott ,Adam R Renslo ,Charles S Craik

Integrated multi-omic characterizations of the synapse reveal RNA processing factors and ubiquitin ligases associated with neurodevelopmental disorders.

对突触进行综合多组学表征,揭示了与神经发育障碍相关的 RNA 加工因子和泛素连接酶

Mei Yuan, Gosztyla Maya L, Tan Xinzhu, Dozier Lara E, Wilkinson Brent, McKetney Justin, Lee John, Chen Michael, Tsai Dorothy, Kopalle Hema, Gritsenko Marina A, Hartel Nicolas, Graham Nicholas A, Flores Ilse, Gilmore-Hall Stephen K, Xu Shuhao, Marquez Charlotte A, Liu Sophie N, Fong Dylan, Chen Jing, Licon Kate, Hong Derek, Wright Sarah N, Kreisberg Jason F, Nott Alexi, Smith Richard D, Qian Wei-Jun, Swaney Danielle L, Iakoucheva Lilia M, Krogan Nevan J, Patrick Gentry N, Zhou Yang, Feng Guoping, Coba Marcelo P, Yeo Gene W, Ideker Trey