日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The genetic architecture of HIV-1 virulence

HIV-1毒力的遗传结构

Blanquart, François; Wymant, Chris; Hall, Matthew; Power, Robert; Golubchik, Tanya; Gall, Astrid; de Cesare, Mariateresa; Macintyre-Cockett, George; Bakker, Margreet; Bezemer, Daniela; Gabrielaite, Migle; Ong, Swee Hoe; Kendall, Michelle; Sauter, Rafael; Bannert, Norbert; Fellay, Jacques; Grabowski, M Kate; Gunsenheimer-Bartmeyer, Barbara; Günthard, Huldrych F; Kivelä, Pia; Kouyos, Roger D; Laeyendecker, Oliver; Marvig, Rasmus L; Meixenberger, Karolin; Meyer, Laurence; van Sighem, Ard; Bonsall, David; van der Valk, Marc; Berkhout, Ben; Kellam, Paul; Cornelissen, Marion; Reiss, Peter; Fraser, Christophe

Loss of histone deubiquitinase Bap1 triggers anti-tumor immunity

组蛋白去泛素化酶Bap1的缺失引发抗肿瘤免疫

Hong Chang #, Mingxia Li #, Linlin Zhang, Meng Li, Swee Hoe Ong, Zhiwei Zhang, Jie Zheng, Xiang Xu, Yu Zhang, Jing Wang, Xingjie Liu, Kairui Li, Yao Luo, Haiyun Wang, Zhichao Miao, Xi Chen, Jie Zha, Yong Yu

HIV-phyloTSI: subtype-independent estimation of time since HIV-1 infection for cross-sectional measures of population incidence using deep sequence data

HIV-phyloTSI:利用深度测序数据,对人群横断面发病率进行HIV-1感染时间的亚型独立估计

Golubchik, Tanya; Abeler-Dörner, Lucie; Hall, Matthew; Wymant, Chris; Bonsall, David; Macintyre-Cockett, George; Thomson, Laura; Baeten, Jared M; Celum, Connie L; Galiwango, Ronald M; Kosloff, Barry; Limbada, Mohammed; Mujugira, Andrew; Mugo, Nelly R; Gall, Astrid; Blanquart, François; Bakker, Margreet; Bezemer, Daniela; Ong, Swee Hoe; Albert, Jan; Bannert, Norbert; Fellay, Jacques; Gunsenheimer-Bartmeyer, Barbara; Günthard, Huldrych F; Kivelä, Pia; Kouyos, Roger D; Meyer, Laurence; Porter, Kholoud; van Sighem, Ard; van der Valk, Mark; Berkhout, Ben; Kellam, Paul; Cornelissen, Marion; Reiss, Peter; Ayles, Helen; Burns, David N; Fidler, Sarah; Grabowski, Mary Kate; Hayes, Richard; Herbeck, Joshua T; Kagaayi, Joseph; Kaleebu, Pontiano; Lingappa, Jairam R; Ssemwanga, Deogratius; Eshleman, Susan H; Cohen, Myron S; Ratmann, Oliver; Laeyendecker, Oliver; Fraser, Christophe

Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus

机体代谢调节正常食管中致癌性PIK3CA突变克隆的扩增

Albert Herms # ,Bartomeu Colom # ,Gabriel Piedrafita ,Argyro Kalogeropoulou ,Ujjwal Banerjee ,Charlotte King ,Emilie Abby ,Kasumi Murai ,Irene Caseda ,David Fernandez-Antoran ,Swee Hoe Ong ,Michael W J Hall ,Christopher Bryant ,Roshan K Sood ,Joanna C Fowler ,Albert Pol ,Christian Frezza ,Bart Vanhaesebroeck ,Philip H Jones

Self-sustaining long-term 3D epithelioid cultures reveal drivers of clonal expansion in esophageal epithelium

能够自我维持的长期三维类上皮细胞培养揭示了食管上皮细胞克隆扩增的驱动因素

Albert Herms # ,David Fernandez-Antoran # ,Maria P Alcolea # ,Argyro Kalogeropoulou ,Ujjwal Banerjee ,Gabriel Piedrafita ,Emilie Abby ,Jose Antonio Valverde-Lopez ,Inês S Ferreira ,Irene Caseda ,Maria T Bejar ,Stefan C Dentro ,Sara Vidal-Notari ,Swee Hoe Ong ,Bartomeu Colom ,Kasumi Murai ,Charlotte King ,Krishnaa Mahbubani ,Kourosh Saeb-Parsy ,Alan R Lowe ,Moritz Gerstung ,Philip H Jones

Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth

Notch1 突变导致正常食管上皮细胞克隆扩增,但会损害肿瘤生长

Emilie Abby, Stefan C Dentro, Michael W J Hall, Joanna C Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W Siebel, Moritz Gerstung, Benjamin A Hall, Philip H Jones

p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition

正常食管中的p53突变会促进癌变的多个阶段,但会受到克隆竞争的限制。

Kasumi Murai ,Stefan Dentro ,Swee Hoe Ong ,Roshan Sood ,David Fernandez-Antoran ,Albert Herms ,Vasiliki Kostiou ,Irina Abnizova ,Benjamin A Hall ,Moritz Gerstung ,Philip H Jones

AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors

AKT-mTORC1 重新激活是 PTEN 基因缺失的乳腺癌中 PI3Kβ/AKT 抑制剂产生耐药性的主要驱动因素,可通过与 Mcl-1 抑制剂联合使用来克服

Shanade Dunn, Cath Eberlein, Jason Yu, Albert Gris-Oliver, Swee Hoe Ong, Urs Yelland, Natalie Cureton, Anna Staniszewska, Robert McEwen, Millie Fox, James Pilling, Philip Hopcroft, Elizabeth A Coker, Patricia Jaaks, Mathew J Garnett, Beverley Isherwood, Violeta Serra, Barry R Davies, Simon T Barry, 

Phylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral load

基于系统发育的HIV-1病毒载量设定点病毒适应度景观估计

Zhao, Lele; Wymant, Chris; Blanquart, François; Golubchik, Tanya; Gall, Astrid; Bakker, Margreet; Bezemer, Daniela; Hall, Matthew; Ong, Swee Hoe; Albert, Jan; Bannert, Norbert; Fellay, Jacques; Grabowski, M Kate; Gunsenheimer-Bartmeyer, Barbara; Günthard, Huldrych F; Kivelä, Pia; Kouyos, Roger D; Laeyendecker, Oliver; Meyer, Laurence; Porter, Kholoud; van Sighem, Ard; van der Valk, Marc; Berkhout, Ben; Kellam, Paul; Cornelissen, Marion; Reiss, Peter; Fraser, Christophe; Ferretti, Luca

Selection of Oncogenic Mutant Clones in Normal Human Skin Varies with Body Site

正常人体皮肤中致癌突变克隆的选择随身体部位的不同而变化

Joanna C Fowler, Charlotte King, Christopher Bryant, Michael W J Hall, Roshan Sood, Swee Hoe Ong, Eleanor Earp, David Fernandez-Antoran, Jonas Koeppel, Stefan C Dentro, David Shorthouse, Amer Durrani, Kate Fife, Edward Rytina, Doreen Milne, Amit Roshan, Krishnaa Mahububani, Kourosh Saeb-Parsy, Benja