日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function

结合基于片段的筛选与靶向蛋白质降解和基因拯救来探索 eIF4E 功能

Swee Y Sharp, Marianna Martella, Sabrina D'Agostino, Christopher I Milton, George Ward, Andrew J Woodhead, Caroline J Richardson, Maria G Carr, Elisabetta Chiarparin, Benjamin D Cons, Joseph Coyle, Charlotte E East, Steven D Hiscock, Carlos Martinez-Fleites, Paul N Mortenson, Nick Palmer, Puja Pathu

Characterizing Nonculprit Lesions and Perivascular Adipose Tissue of Patients Following Acute Myocardial Infarction Using Coronary Computed Tomography Angiography: A Comparative Study

利用冠状动脉计算机断层扫描血管造影术对急性心肌梗死患者非罪犯病变和血管周围脂肪组织进行特征分析:一项比较研究

Wang, Xiaomeng; Sia, Ching H; Adamson, Philip D; Greer, Charlotte E; Huang, Weimin; Lee, Hwee K; Leng, Shuang; Loong, Yan T; Raffiee, Nur A S; Tan, Swee Y; Tan, Sock H; Teo, Lynette L S; Wong, Sung L; Yang, Xiaoxun; Yew, Min S; Yong, Thon H; Zhong, Liang; Shaw, Leslee J; Chan, Mark Y Y; Hausenloy, Derek J; Baskaran, Lohendran

Evaluating the American Heart Association/American College of Cardiology Guideline-Recommended and Contemporary Pretest Probability Models in a Mixed Asian Cohort: The Contribution of Coronary Artery Calcium

在混合亚洲人群队列中评估美国心脏协会/美国心脏病学会指南推荐的和当代预检概率模型:冠状动脉钙化的影响

Baskaran, Lohendran; Yan, Linxuan; Tan, Chun S; Ho, Woon W; Tan, Swee Y; Williams, Michelle C; Han, Donghee; Nakanishi, Rine; Cerci, Rodrigo J; Ng, Ming-Yen; Shaw, Leslee J; Chua, Terrance S J; Douglas, Pamela; Winther, Simon

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies

HSF1通路抑制剂临床候选药物(CCT361814/NXP800)基于表型筛选开发,有望用于治疗难治性卵巢癌和其他恶性肿瘤。

Pasqua, A Elisa; Sharp, Swee Y; Chessum, Nicola E A; Hayes, Angela; Pellegrino, Loredana; Tucker, Michael J; Miah, Asadh; Wilding, Birgit; Evans, Lindsay E; Rye, Carl S; Mok, N Yi; Liu, Manjuan; Henley, Alan T; Gowan, Sharon; De Billy, Emmanuel; Te Poele, Robert; Powers, Marissa; Eccles, Suzanne A; Clarke, Paul A; Raynaud, Florence I; Workman, Paul; Jones, Keith; Cheeseman, Matthew D

Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data

根据临床概率和临床重要亚组,采用计算机断层扫描血管造影术诊断稳定性胸痛患者的阻塞性冠状动脉疾病:个体患者数据的荟萃分析

Haase, Robert; Schlattmann, Peter; Gueret, Pascal; Andreini, Daniele; Pontone, Gianluca; Alkadhi, Hatem; Hausleiter, Jörg; Garcia, Mario J; Leschka, Sebastian; Meijboom, Willem B; Zimmermann, Elke; Gerber, Bernhard; Schoepf, U Joseph; Shabestari, Abbas A; Nørgaard, Bjarne L; Meijs, Matthijs F L; Sato, Akira; Ovrehus, Kristian A; Diederichsen, Axel C P; Jenkins, Shona M M; Knuuti, Juhani; Hamdan, Ashraf; Halvorsen, Bjørn A; Mendoza-Rodriguez, Vladimir; Rochitte, Carlos E; Rixe, Johannes; Wan, Yung Liang; Langer, Christoph; Bettencourt, Nuno; Martuscelli, Eugenio; Ghostine, Said; Buechel, Ronny R; Nikolaou, Konstantin; Mickley, Hans; Yang, Lin; Zhang, Zhaqoi; Chen, Marcus Y; Halon, David A; Rief, Matthias; Sun, Kai; Hirt-Moch, Beatrice; Niinuma, Hiroyuki; Marcus, Roy P; Muraglia, Simone; Jakamy, Réda; Chow, Benjamin J; Kaufmann, Philipp A; Tardif, Jean-Claude; Nomura, Cesar; Kofoed, Klaus F; Laissy, Jean-Pierre; Arbab-Zadeh, Armin; Kitagawa, Kakuya; Laham, Roger; Jinzaki, Masahiro; Hoe, John; Rybicki, Frank J; Scholte, Arthur; Paul, Narinder; Tan, Swee Y; Yoshioka, Kunihiro; Röhle, Robert; Schuetz, Georg M; Schueler, Sabine; Coenen, Maria H; Wieske, Viktoria; Achenbach, Stephan; Budoff, Matthew J; Laule, Michael; Newby, David E; Dewey, Marc

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)

使用 Pirin 蛋白降解探针 (CCT367766) 展示细胞内靶标参与

Nicola E A Chessum, Swee Y Sharp, John J Caldwell, A Elisa Pasqua, Birgit Wilding, Giampiero Colombano, Ian Collins, Bugra Ozer, Meirion Richards, Martin Rowlands, Mark Stubbs, Rosemary Burke, P Craig McAndrew, Paul A Clarke, Paul Workman, Matthew D Cheeseman, Keith Jones

Mechanisms Underlying the Anti-Inflammatory Effects of Clinacanthus nutans Lindau Extracts: Inhibition of Cytokine Production and Toll-Like Receptor-4 Activation

Clinacanthus nutans Lindau 提取物抗炎作用的机制:抑制细胞因子产生和 Toll 样受体 4 激活

Chun W Mai, Kok S I Yap, Mee T Kho, Nor H Ismail, Khatijah Yusoff, Khozirah Shaari, Swee Y Chin, Erin S H Lim

Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9

发现 4,6-二取代嘧啶类化合物是热休克因子 1 (HSF1) 应激通路和 CDK9 的有效抑制剂

Rye, Carl S; Chessum, Nicola E A; Lamont, Scott; Pike, Kurt G; Faulder, Paul; Demeritt, Julie; Kemmitt, Paul; Tucker, Julie; Zani, Lorenzo; Cheeseman, Matthew D; Isaac, Rosie; Goodwin, Louise; Boros, Joanna; Raynaud, Florence; Hayes, Angela; Henley, Alan T; de Billy, Emmanuel; Lynch, Christopher J; Sharp, Swee Y; Te Poele, Robert; Fee, Lisa O'; Foote, Kevin M; Green, Stephen; Workman, Paul; Jones, Keith

Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma.

对新型 HSP90 抑制剂 NVP-AUY922 在成人和儿童胶质母细胞瘤中的机制评价

Gaspar Nathalie, Sharp Swee Y, Eccles Suzanne A, Gowan Sharon, Popov Sergey, Jones Chris, Pearson Andrew, Vassal Gilles, Workman Paul

Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition

热休克蛋白 90 抑制对黑色素瘤细胞磷脂代谢的调节

Mounia Beloueche-Babari, Vaitha Arunan, L Elizabeth Jackson, Nina Perusinghe, Swee Y Sharp, Paul Workman, Martin O Leach