日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function

结合基于片段的筛选与靶向蛋白质降解和基因拯救来探索 eIF4E 功能

Swee Y Sharp, Marianna Martella, Sabrina D'Agostino, Christopher I Milton, George Ward, Andrew J Woodhead, Caroline J Richardson, Maria G Carr, Elisabetta Chiarparin, Benjamin D Cons, Joseph Coyle, Charlotte E East, Steven D Hiscock, Carlos Martinez-Fleites, Paul N Mortenson, Nick Palmer, Puja Pathu

Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)

使用 Pirin 蛋白降解探针 (CCT367766) 展示细胞内靶标参与

Nicola E A Chessum, Swee Y Sharp, John J Caldwell, A Elisa Pasqua, Birgit Wilding, Giampiero Colombano, Ian Collins, Bugra Ozer, Meirion Richards, Martin Rowlands, Mark Stubbs, Rosemary Burke, P Craig McAndrew, Paul A Clarke, Paul Workman, Matthew D Cheeseman, Keith Jones

Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition

热休克蛋白 90 抑制对黑色素瘤细胞磷脂代谢的调节

Mounia Beloueche-Babari, Vaitha Arunan, L Elizabeth Jackson, Nina Perusinghe, Swee Y Sharp, Paul Workman, Martin O Leach

EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines

儿童高级别胶质瘤的 EGFRvIII 缺失突变及儿童胶质瘤细胞系对靶向治疗的反应

Dorine A Bax, Nathalie Gaspar, Suzanne E Little, Lynley Marshall, Lara Perryman, Marie Regairaz, Marta Viana-Pereira, Raisa Vuononvirta, Swee Y Sharp, Jorge S Reis-Filho, João N Stávale, Safa Al-Sarraj, Rui M Reis, Gilles Vassal, Andrew D J Pearson, Darren Hargrave, David W Ellison, Paul Workman, Ch

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis

NVP-AUY922:一种新型热休克蛋白 90 抑制剂,可抑制异种移植肿瘤的生长、血管生成和转移

Suzanne A Eccles, Andy Massey, Florence I Raynaud, Swee Y Sharp, Gary Box, Melanie Valenti, Lisa Patterson, Alexis de Haven Brandon, Sharon Gowan, Frances Boxall, Wynne Aherne, Martin Rowlands, Angela Hayes, Vanessa Martins, Frederique Urban, Kathy Boxall, Chrisostomos Prodromou, Laurence Pearl, Kar

An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models

热休克蛋白抑制剂17-烯丙基氨基-17-去甲氧基格尔德霉素与卡铂联合用于人卵巢癌模型的体内外研究

Udai Banerji, Nivedita Sain, Swee Y Sharp, Melanie Valenti, Yasmin Asad, Ruth Ruddle, Florence Raynaud, Michael Walton, Suzanne A Eccles, Ian Judson, Ann L Jackman, Paul Workman