日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH.

真核细胞中的血红素分配依赖于线粒体通过 FLVCR1b 将血红素输出到胞质 GAPDH

Jayaram Dhanya Thamaraparambil, Sivaram Pranav, Biswas Pranjal, Dai Yue, Sweeny Elizabeth A, Stuehr Dennis J

Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting.

利用同步辐射 X 射线足迹分析揭示 Hsp104 功能的结构和机制

Sweeny Elizabeth A, Tariq Amber, Gurpinar Esin, Go Michelle S, Sochor Matthew A, Kan Zhong-Yuan, Mayne Leland, Englander S Walter, Shorter James

Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases

Hsp104及其增强变体可作为不同的非连续性转位酶发挥作用

Durie, Clarissa L; Lin, JiaBei; Scull, Nathaniel W; Mack, Korrie L; Jackrel, Meredith E; Sweeny, Elizabeth A; Castellano, Laura M; Shorter, James; Lucius, Aaron L

Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells

甘油醛-3-磷酸脱氢酶是一种分子伴侣,负责在细胞内分配不稳定的血红素。

Sweeny, Elizabeth A; Singh, Anuradha Bharara; Chakravarti, Ritu; Martinez-Guzman, Osiris; Saini, Arushi; Haque, Mohammad Mahfuzul; Garee, Greer; Dans, Pablo D; Hannibal, Luciana; Reddi, Amit R; Stuehr, Dennis J

Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104

Hsp104朊病毒解聚酶活性的机制和结构见解

Sweeny, Elizabeth A; Shorter, James

The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation

Hsp104 N端结构域赋予解聚酶可塑性和增强作用

Sweeny, Elizabeth A; Jackrel, Meredith E; Go, Michelle S; Sochor, Matthew A; Razzo, Beatrice M; DeSantis, Morgan E; Gupta, Kushol; Shorter, James

Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation.

Hsp104 和 ClpB 中间结构域中保守的远端环残基与核苷酸结合结构域 2 接触,并能使 Hsp70 依赖性蛋白质解聚

Desantis Morgan E, Sweeny Elizabeth A, Snead David, Leung Eunice H, Go Michelle S, Gupta Kushol, Wendler Petra, Shorter James

Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients

功能上的可塑性使hsp104能够分解不同的淀粉样蛋白和非淀粉样蛋白底物。

DeSantis, Morgan E; Leung, Eunice H; Sweeny, Elizabeth A; Jackrel, Meredith E; Cushman-Nick, Mimi; Neuhaus-Follini, Alexandra; Vashist, Shilpa; Sochor, Matthew A; Knight, M Noelle; Shorter, James

A synergistic small-molecule combination directly eradicates diverse prion strain structures

协同作用的小分子组合可直接根除多种朊病毒株结构。

Roberts, Blake E; Duennwald, Martin L; Wang, Huan; Chung, Chan; Lopreiato, Nicholas P; Sweeny, Elizabeth A; Knight, M Noelle; Shorter, James

Prion proteostasis: Hsp104 meets its supporting cast

朊病毒蛋白稳态:Hsp104 与其支持群体相遇

Sweeny, Elizabeth A; Shorter, James