GalNAc-conjugated siRNA targeting C/EBPβ reverses metabolic dysfunction and restores liver homeostasis in a murine MASLD model
在小鼠MASLD模型中,靶向C/EBPβ的GalNAc偶联siRNA可逆转代谢功能障碍并恢复肝脏稳态。
期刊:Molecular Therapy-Nucleic Acids
影响因子:6.1
doi:10.1016/j.omtn.2026.102865
Khorsandi, Shirin Elizabeth; Vasconcelos, Daniel; Nicholas, Roman; Reebye, Vikash; Nicholls, Joanna; Sodergren, Mikael; Rowell, James; Dehkordi, Arash; Habib, Nagy; Swiderski, Piotr; Rossi, John; Huang, Kai-Wen