日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs

胞外DNA携带的PVT1融合蛋白可稳定致癌mRNA

Yi, Hyerim; Zhang, Shu; Swinderman, Jason; Wang, Yanbo; Kanakaveti, Vishnupriya; Hung, King L; Wong, Ivy Tsz-Lo; Srinivasan, Suhas; Curtis, Ellis J; Bhargava-Shah, Aarohi; Li, Rui; Jones, Matthew G; Luebeck, Jens; Zhao, Yanding; Belk, Julia A; Kraft, Katerina; Shi, Quanming; Yan, Xiaowei; Pritchard, Simon K; Liang, Frances M; Felsher, Dean W; Gilbert, Luke A; Bafna, Vineet; Mischel, Paul S; Chang, Howard Y

Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer.

转录和 DNA 复制的冲突会导致大量的串联重复,并暴露出癌症中可靶向治疗的弱点

Yang Yang, Badura Michelle L, O'Leary Patrick C, Delavan Henry M, Robinson Troy M, Egusa Emily A, Zhong Xiaoming, Swinderman Jason T, Li Haolong, Zhang Meng, Kim Minkyu, Ashworth Alan, Feng Felix Y, Chou Jonathan, Yang Lixing

Synthetic Lethal Targeting of CDK12-Deficient Prostate Cancer with PARP Inhibitors.

利用 PARP 抑制剂对 CDK12 缺陷型前列腺癌进行合成致死靶向治疗

Chou Jonathan, Robinson Troy M, Egusa Emily A, Lodha Roshan, Zhang Meng, Badura Michelle, Mikayelyan Mane, Delavan Henry M, Swinderman Jason, Wilson Chris, Zhu Jun, Das Rajdeep, Nguyen Minh, Loehr Andrea, Golsorkhi Tony, Simmons Andrew, Abida Wassim, Chinnaiyan Arul M, Arkin Michelle R, Small Eric J, Quigley David A, Yang Lixing, Kim Minkyu, Ashworth Alan, Feng Felix Y