Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia
异二聚体VHL-SOCS1 E3泛素连接酶介导的JAK2调控丧失是楚瓦什红细胞增多症的根本原因。
期刊:Nature Medicine
影响因子:50
doi:10.1038/nm.2370
Russell, Ryan C; Sufan, Roxana I; Zhou, Bing; Heir, Pardeep; Bunda, Severa; Sybingco, Stephanie S; Greer, Samantha N; Roche, Olga; Heathcote, Samuel A; Chow, Vinca W K; Boba, Lukasz M; Richmond, Terri D; Hickey, Michele M; Barber, Dwayne L; Cheresh, David A; Simon, M Celeste; Irwin, Meredith S; Kim, William Y; Ohh, Michael
SOCS1
JAK/STAT
信号转导
JAK2
红细胞
细胞生物学
VHL