日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Coniontins, lipopetaibiotics active against Candida auris identified from a microbial natural product fractionation library

从微生物天然产物分离库中鉴定出的具有抗耳念珠菌活性的脂肽类抗生素——康宁汀。

Xuefei Chen ,Kalinka Koteva ,Sommer Chou ,Allison Guitor ,Daniel Pallant ,Yunjin Lee ,David Sychantha ,Shawn French ,Dirk Hackenberger ,Nicole Robbins ,Michael A Cook ,Eric D Brown ,Lesley T MacNeil ,Leah E Cowen ,Gerard D Wright

A microbial natural product fractionation library screen with HRMS/MS dereplication identifies new lipopeptaibiotics against Candida auris.

利用 HRMS/MS 去重复技术对微生物天然产物分离库进行筛选,鉴定出针对耳念珠菌的新型脂肽抗生素

Wright Gerard, Chen Xuefei, Koteva Kalinka, Chou Sommer, Guitor Allison, Pallant Daniel, Lee Yunjin, Sychantha David, French Shawn, Hackenberger Dirk, Robbins Nicole, Cook Michael, Brown Eric, MacNeil Lesley, Cowen Leah

Synthesis of lipid-linked precursors of the bacterial cell wall is governed by a feedback control mechanism in Pseudomonas aeruginosa

细菌细胞壁脂质连接前体的合成受铜绿假单胞菌的反馈控制机制控制

Lindsey S Marmont, Anna K Orta, Becca W A Baileeves, David Sychantha, Ana Fernández-Galliano, Yancheng E Li, Neil G Greene, Robin A Corey, Phillip J Stansfeld, William M Clemons Jr, Thomas G Bernhardt

Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes

利用曲霉毒素A靶向细菌镍转运可抑制与毒力相关的镍依赖性酶

Sychantha, David; Chen, Xuefei; Koteva, Kalinka; Prehna, Gerd; Wright, Gerard D

Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity.

N-嘧啶基-β-硫代苯基丙烯酰胺对 tRNA 合成酶 Gln4 的变构抑制作用具有高度选择性的抗真菌活性

Puumala Emily, Sychantha David, Lach Elizabeth, Reeves Shawn, Nabeela Sunna, Fogal Meea, Nigam AkshatKumar, Johnson Jarrod W, Aspuru-Guzik Alán, Shapiro Rebecca S, Uppuluri Priya, Kalyaanamoorthy Subha, Magolan Jakob, Whitesell Luke, Robbins Nicole, Wright Gerard D, Cowen Leah E

The antibacterial activity of a prophage-encoded fitness factor is neutralized by two cognate immunity proteins

一种由原噬菌体编码的适应因子的抗菌活性会被两种相应的免疫蛋白中和。

Alexei, Andrea G; Bullen, Nathan P; Garrett, Stephen R; Sychantha, David; Whitney, John C

Identification of a broadly conserved family of enzymes that hydrolyze (p)ppApp

鉴定出一类广泛保守的酶家族,该家族可水解(p)ppApp。

Ahmad, Shehryar; Gordon, Isis J; Tsang, Kara K; Alexei, Andrea G; Sychantha, David; Colautti, Jake; Trilesky, Sarah L; Kim, Youngchang; Wang, Boyuan; Whitney, John C

A feedback control mechanism governs the synthesis of lipid-linked precursors of the bacterial cell wall

反馈控制机制调控细菌细胞壁脂质连接前体的合成。

Marmont, Lindsey S; Orta, Anna K; Corey, Robin A; Sychantha, David; Galliano, Ana Fernández; Li, Yancheng E; Baileeves, Becca W A; Greene, Neil G; Stansfeld, Phillip J; Clemons, William M Jr; Bernhardt, Thomas G

Three-Dimensional Structure and Optimization of the Metallo-β-Lactamase Inhibitor Aspergillomarasmine A

金属β-内酰胺酶抑制剂Aspergillomarasmine A的三维结构及优化

Kalinka Koteva, David Sychantha, Caitlyn M Rotondo, Christian Hobson, James F Britten, Gerard D Wright

Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn(2).

Aspergillomarasmine A 通过选择性螯合 Zn(2) 来抑制金属β-内酰胺酶

Sychantha David, Rotondo Caitlyn M, Tehrani Kamaleddin H M E, Martin Nathaniel I, Wright Gerard D