日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A microbial natural product fractionation library screen with HRMS/MS dereplication identifies new lipopeptaibiotics against Candida auris.

利用 HRMS/MS 去重复技术对微生物天然产物分离库进行筛选,鉴定出针对耳念珠菌的新型脂肽抗生素

Wright Gerard, Chen Xuefei, Koteva Kalinka, Chou Sommer, Guitor Allison, Pallant Daniel, Lee Yunjin, Sychantha David, French Shawn, Hackenberger Dirk, Robbins Nicole, Cook Michael, Brown Eric, MacNeil Lesley, Cowen Leah

Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes

利用曲霉毒素A靶向细菌镍转运可抑制与毒力相关的镍依赖性酶

Sychantha, David; Chen, Xuefei; Koteva, Kalinka; Prehna, Gerd; Wright, Gerard D

Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity.

N-嘧啶基-β-硫代苯基丙烯酰胺对 tRNA 合成酶 Gln4 的变构抑制作用具有高度选择性的抗真菌活性

Puumala Emily, Sychantha David, Lach Elizabeth, Reeves Shawn, Nabeela Sunna, Fogal Meea, Nigam AkshatKumar, Johnson Jarrod W, Aspuru-Guzik Alán, Shapiro Rebecca S, Uppuluri Priya, Kalyaanamoorthy Subha, Magolan Jakob, Whitesell Luke, Robbins Nicole, Wright Gerard D, Cowen Leah E

The antibacterial activity of a prophage-encoded fitness factor is neutralized by two cognate immunity proteins

一种由原噬菌体编码的适应因子的抗菌活性会被两种相应的免疫蛋白中和。

Alexei, Andrea G; Bullen, Nathan P; Garrett, Stephen R; Sychantha, David; Whitney, John C

Identification of a broadly conserved family of enzymes that hydrolyze (p)ppApp

鉴定出一类广泛保守的酶家族,该家族可水解(p)ppApp。

Ahmad, Shehryar; Gordon, Isis J; Tsang, Kara K; Alexei, Andrea G; Sychantha, David; Colautti, Jake; Trilesky, Sarah L; Kim, Youngchang; Wang, Boyuan; Whitney, John C

A feedback control mechanism governs the synthesis of lipid-linked precursors of the bacterial cell wall

反馈控制机制调控细菌细胞壁脂质连接前体的合成。

Marmont, Lindsey S; Orta, Anna K; Corey, Robin A; Sychantha, David; Galliano, Ana Fernández; Li, Yancheng E; Baileeves, Becca W A; Greene, Neil G; Stansfeld, Phillip J; Clemons, William M Jr; Bernhardt, Thomas G

Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn(2).

Aspergillomarasmine A 通过选择性螯合 Zn(2) 来抑制金属β-内酰胺酶

Sychantha David, Rotondo Caitlyn M, Tehrani Kamaleddin H M E, Martin Nathaniel I, Wright Gerard D

Suppression of β-Lactam Resistance by Aspergillomarasmine A Is Influenced by both the Metallo-β-Lactamase Target and the Antibiotic Partner

阿斯帕吉洛马司明A对β-内酰胺类抗生素耐药性的抑制作用受金属β-内酰胺酶靶点和抗生素伴侣的双重影响

Rotondo, Caitlyn M; Sychantha, David; Koteva, Kalinka; Wright, Gerard D

Correction: Peptidoglycomics reveals compositional changes in peptidoglycan between biofilm- and planktonic-derived Pseudomonas aeruginosa

更正:肽聚糖组学揭示了生物膜来源和浮游来源的铜绿假单胞菌肽聚糖的组成变化

Anderson, Erin M; Sychantha, David; Brewer, Dyanne; Clarke, Anthony J; Geddes-McAlister, Jennifer; Khursigara, Cezar M

Structural basis for the O-acetyltransferase function of the extracytoplasmic domain of OatA from Staphylococcus aureus.

金黄色葡萄球菌 OatA 胞外结构域 O-乙酰转移酶功能的结构基础

Jones Carys S, Sychantha David, Howell P Lynne, Clarke Anthony J