日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The non-cytotoxic small molecule NPB does not inhibit BAD phosphorylation and forms colloidal aggregates.

无细胞毒性的小分子 NPB 不抑制 BAD 磷酸化,并形成胶体聚集体

Githaka John Maringa, Gutiérrez Tomás, Han Zhuang Zhuang, Primeau Joseph O, Muranyi Heather, Young Howard S, Sykes Brian D, Julien Olivier, Goping Ing Swie

The calcium sensitizer drug MCI-154 binds the structural C-terminal domain of cardiac troponin C

钙敏化剂药物MCI-154与心肌肌钙蛋白C的结构C端结构域结合。

Li, Monica X; Gelozia, Shorena; Danmaliki, Gaddafi I; Wen, Yurong; Liu, Philip B; Lemieux, M Joanne; West, Frederick G; Sykes, Brian D; Hwang, Peter M

Structures reveal details of small molecule binding to cardiac troponin

结构揭示了小分子与心肌肌钙蛋白结合的细节

Cai, Fangze; Li, Monica X; Pineda-Sanabria, Sandra E; Gelozia, Shorena; Lindert, Steffen; West, Frederick; Sykes, Brian D; Hwang, Peter M

The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29Q.

家族性肥厚型心肌病相关心肌肌钙蛋白 C 突变 L29Q 的结构和功能影响

Robertson Ian M, Sevrieva Ivanka, Li Monica X, Irving Malcolm, Sun Yin-Biao, Sykes Brian D

Computer-aided drug discovery approach finds calcium sensitizer of cardiac troponin

计算机辅助药物发现方法找到了心肌肌钙蛋白的钙敏化剂

Lindert, Steffen; Li, Monica X; Sykes, Brian D; McCammon, J Andrew

The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C

肌钙蛋白I的心脏特异性N端区域定位肌钙蛋白C的调节结构域

Hwang, Peter M; Cai, Fangze; Pineda-Sanabria, Sandra E; Corson, David C; Sykes, Brian D

Structural and functional analysis of transmembrane segment IV of the salt tolerance protein Sod2

耐盐蛋白Sod2跨膜区段IV的结构和功能分析

Ullah, Asad; Kemp, Grant; Lee, Brian; Alves, Claudia; Young, Howard; Sykes, Brian D; Fliegel, Larry

Expression of Saccharomyces cerevisiae Sdh3p and Sdh4p paralogs results in catalytically active succinate dehydrogenase isoenzymes

酿酒酵母Sdh3p和Sdh4p旁系同源基因的表达可产生具有催化活性的琥珀酸脱氢酶同工酶。

Szeto, Samuel S W; Reinke, Stacey N; Oyedotun, Kayode S; Sykes, Brian D; Lemire, Bernard D

Structural and functional consequences of the cardiac troponin C L48Q Ca(2+)-sensitizing mutation

心肌肌钙蛋白C L48Q Ca(2+) 敏感突变的结构和功能后果

Wang, Dan; Robertson, Ian M; Li, Monica X; McCully, Michelle E; Crane, Melissa L; Luo, Zhaoxiong; Tu, An-Yue; Daggett, Valerie; Sykes, Brian D; Regnier, Michael

Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch region of cardiac troponin I and W7: the basis of W7 as an inhibitor of cardiac muscle contraction

人源心肌肌钙蛋白C调节域与心肌肌钙蛋白I和W7的复合物的溶液结构:W7作为心肌收缩抑制剂的基础

Oleszczuk, Marta; Robertson, Ian M; Li, Monica X; Sykes, Brian D