Optimization of 2,8-Diaryl-1,5-naphthyridines as Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy
优化 2,8-二芳基-1,5-萘啶类化合物作为恶性疟原虫磷脂酰肌醇 4-激酶抑制剂，以改善其 ADME 特性和体内疗效
期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c02248
Dziwornu, Godwin A; Seanego, Donald; Fienberg, Stephen; Sypu, Venkata S; Salomane, Nicolaas; Krugmann, Liezl; Taylor, Dale; Masike, Keabetswe; Njoroge, Mathew; Boonyalai, Nonlawat; Lee, Marcus C S; Godoy, Luiz C; Pasaje, Charisse Flerida; Niles, Jacquin C; Basarab, Gregory S; Coulson, Lauren B; Ghorpade, Sandeep R; Chibale, Kelly
