日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate

重点筛选确定人类 TET 加氧酶对癌代谢物 2-羟基戊二酸的不同敏感性

Roman Belle, Hilal Saraç, Eidarus Salah, Bhaskar Bhushan, Aleksandra Szykowska, Grace Roper, Anthony Tumber, Skirmantas Kriaucionis, Nicola Burgess-Brown, Christopher J Schofield, Tom Brown, Akane Kawamura

Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain

降低脱落胞外域水平的抗 TREM2 scFv 的选择和结构表征

Aleksandra Szykowska, Yu Chen, Thomas B Smith, Charlotta Preger, Jingjing Yang, Dongming Qian, Shubhashish M Mukhopadhyay, Edvard Wigren, Stephen J Neame, Susanne Gräslund, Helena Persson, Peter J Atkinson, Elena Di Daniel, Emma Mead, John Wang, John B Davis, Nicola A Burgess-Brown, Alex N Bullock

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

强效且选择性的 KDM5 抑制剂可阻止转录起始位点的 H3K4me3 细胞去甲基化和 MM1S 骨髓瘤细胞的增殖

Anthony Tumber, Andrea Nuzzi, Edward S Hookway, Stephanie B Hatch, Srikannathasan Velupillai, Catrine Johansson, Akane Kawamura, Pavel Savitsky, Clarence Yapp, Aleksandra Szykowska, Na Wu, Chas Bountra, Claire Strain-Damerell, Nicola A Burgess-Brown, Gian Filippo Ruda, Oleg Fedorov, Shonagh Munro, K

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates

组蛋白去甲基化酶KDM5B与三羧酸循环中间体的相互作用研究

Hanna Tarhonskaya, Radosław P Nowak, Catrine Johansson, Aleksandra Szykowska, Anthony Tumber, Rebecca L Hancock, Pauline Lang, Emily Flashman, Udo Oppermann, Christopher J Schofield, Akane Kawamura

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor

对基于三唑并吡啶的组蛋白去甲基化酶抑制剂进行优化,得到一种高效且选择性的KDM2A(FBXL11)抑制剂。

England, Katherine S; Tumber, Anthony; Krojer, Tobias; Scozzafava, Giuseppe; Ng, Stanley S; Daniel, Michelle; Szykowska, Aleksandra; Che, KaHing; von Delft, Frank; Burgess-Brown, Nicola A; Kawamura, Akane; Schofield, Christopher J; Brennan, Paul E

Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor

THO复合物(一种mRNP组装因子)的结构和核酸识别机制

Peña, Alvaro; Gewartowski, Kamil; Mroczek, Seweryn; Cuéllar, Jorge; Szykowska, Aleksandra; Prokop, Andrzej; Czarnocki-Cieciura, Mariusz; Piwowarski, Jan; Tous, Cristina; Aguilera, Andrés; Carrascosa, José L; Valpuesta, José María; Dziembowski, Andrzej