Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells
VLX1570 与去泛素化酶 USP14 和 UCHL5 的联合抑制对伊布替尼或硼替佐米耐药的华氏巨球蛋白血症肿瘤细胞具有致命作用。
期刊:Blood Cancer Journal
影响因子:12.9
doi:10.1038/bcj.2016.93
A Paulus ,S Akhtar ,T R Caulfield ,K Samuel ,H Yousaf ,Y Bashir ,S M Paulus ,D Tran ,R Hudec ,D Cogen ,J Jiang ,B Edenfield ,A Novak ,S M Ansell ,T Witzig ,P Martin ,M Coleman ,V Roy ,S Ailawadhi ,K Chitta ,S Linder ,A Chanan-Khan
肿瘤免疫
肿瘤细胞
USP14
细胞生物学
表观遗传
肿瘤
SP1
UCHL5
泛素化