日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

APOE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes.

APOE4 驱动星形胶质细胞的适应不良异质性和免疫代谢反应。

Goulding Danielle S, Williams Holden C, Gorman Amy A, Devanney Nicholas A, Harrison Douglas A, Walsh Adeline E, Tuck Tony, Zajac Diana J, Macauley Shannon L, Estus Steven, Tcw Julia, A Johnson Lance, Morganti Josh M

Protocol for morphogen-guided differentiation of brain cell types using human induced pluripotent stem cells.

利用人类诱导多能干细胞进行形态发生素引导的脑细胞类型分化的方案。

Qian Lu, Rosa Juao-Guilherme, Tcw Julia

Factorization of Alzheimer's disease genetic risk influences allow patient stratification, predicting disease onset, cognitive decline, and cell-type specific responses

对阿尔茨海默病遗传风险因素进行因子分析,可以对患者进行分层,预测疾病发作、认知衰退和细胞类型特异性反应。

Pelletier, Alexandre; Tuck, Tony; Tcw, Julia

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks.

非小胶质细胞中 PLCG2 的下调会损害突触功能,并引发阿尔茨海默病相关的特征。

Coulon Audrey, Rabiller Florian, Takalo Mari, Roy Avishek, Pelletier Alexandre, Martiskainen Henna, Siedlecki-Wullich Dolores, Lannette-Weimann Nina, Majerníková Nad'a, Grenon Arthur, Gao Vance, Erhardt Anaël, Pernodet Anne, Lemaire Morgane, Limoge Floriane, Walle Pauline, Mendes Tiago, Guyot Karine, Lemeu Célia, Carvalho Lukas-Iohan, de Farias Ana Raquel Melo, Hulsman Marc, Najdek Chloé, Freire-Regatillo Alejandra, Saha Orthis, Amouyel Philippe, Charbonnier Camille, Deleuze Jean-François, Dols-Icardo Orio, Jeskanen Heli, Willman Roosa-Maria, Kuulasmaa Teemu, Kurki Mitja, Hardy John, Heikkinen Sami, Holstege Henne, Mäkinen Petra, Nicolas Gaël, Mead Simon, Wagner Michael, Ramirez Alfredo, Rauramaa Tuomas, Palotie Aarno, Sims Rebecca, Soininen Hilkka, van Swieten John, Williams Julie, Bellenguez Céline, Gelle Carla, Lambert Erwan, Costa Marcos R, Tcw Julia, Glaab Enrico, Ayral Anne-Marie, Demiautte Florie, Grenier-Boley Benjamin, Muntaner Manon, Eberlé Delphine, Deforges Séverine, Haas Joel, Kilinc Devrim, Mulle Christophe, Chapuis Julien, Hiltunen Mikko, Dumont Julie, Lambert Jean-Charles

Multiscale proteomic modeling reveals protein networks driving Alzheimer's disease pathogenesis.

多尺度蛋白质组学建模揭示了驱动阿尔茨海默病发病机制的蛋白质网络。

Wang Erming, Yu Kaiwen, Cao Jiqing, Wang Minghui, Katsel Pavel, Song Won-Min, Wang Zhen, Li Yuxin, Wang Xusheng, Wang Qian, Xu Peng, Yu Gefei, Zhu Li, Geng Jia, Habibi Parnian, Qian Lu, Tuck Tony, Li Aiqun, Tcw Julia, Roussos Panos, Brennand Kristen J, Haroutunian Vahram, Johnson Erik C B, Seyfried Nicholas T, Levey Allan I, Bennett David A, Peng Junmin, Cai Dongming, Zhang Bin

Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD

胆固醇积累诱导的细胞衰老是由APOE4和AD中的溶酶体ABCA1介导的。

Wang, Shaowei; Li, Boyang; Li, Jie; Cai, Zhiheng; Hugo, Cristelle; Sun, Yi; Qian, Lu; Tcw, Julia; Chui, Helena C; Dikeman, Dante; Asante, Isaac; Louie, Stan G; Bennett, David A; Arvanitakis, Zoe; Remaley, Alan T; Kerman, Bilal E; Yassine, Hussein N

Impact of APOE on cerebrovascular lipid profile in Alzheimer's disease.

APOE 对阿尔茨海默病患者脑血管脂质谱的影响。

Inoue Yasuteru, Wang Hu, Heckman Michael G, Ren Yingxue, White Launia J, Lu Wenyan, Wang Pengjiao, Tcw Julia, Koga Shunsuke, Alnobani Alla, DeTure Michael, Murray Melissa E, Petersen Ronald C, Dickson Dennis W, Bu Guojun, Han Xianlin, Kanekiyo Takahisa

APOE-Targeted Therapeutics for Alzheimer's Disease

针对阿尔茨海默病的APOE靶向疗法

Yassine, Hussein N; Hugo, Cristelle; O'Donovan, Bernadette; Stephens, Isaiah O; Johnson, Lance A; Cole, Gregory; Tcw, Julia; Johansson, Jan; Kisler, Kassandra; Chiba-Falek, Ornit

Brain pericytes derived from human pluripotent stem cells retain vascular and phagocytic functions under hypoxia

源自人类多能干细胞的脑周细胞在缺氧条件下仍保留血管和吞噬功能

Zhang, Mingzi; Kim, Youbin; Bosworth, Allison; Tcw, Julia; Nih, Lina R; Kisler, Kassandra; Sagare, Abhay P; Rust, Ruslan

APOE4 driven splicing defects disrupt neurite projection in excitatory neurons

APOE4驱动的剪接缺陷会破坏兴奋性神经元的神经突投射。

Knep, Evan; Velosa, Angelica; Mueller, Dana; Chen, Cathy S; Vinogradov, Sophia; Chafee, Matthew; Ebitz, Becket; Heilbronner, Sarah; Rothwell, Patrick E; Grissom, Nicola; Pelletier, Alexandre; Qian, Lu; Tuck, Tony; TCW, Julia