Protodioscin enhances Methotrexate-induced senescence and senolytic activity in HepG2 liver cancer spheroids by modulating cell cycle regulators and the TGF-β/p-Smad2-4 signaling pathway
原薯蓣皂苷通过调节细胞周期调节因子和TGF-β/p-Smad2-4信号通路,增强甲氨蝶呤诱导的HepG2肝癌球体衰老和衰老细胞清除活性。
期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-27926-6
Jafaei Souq, Alborz; Ghanbari, Ali; Tabandeh, Mohammad Reza; Zamir Nasta, Touraj; Faramarzi, Azita; Makalani, Fatemeh; Jalili, Cyrus