Taebo相关文献与解析，生知库 | 链接生命科学的每一步

Targeted autophagic clearance of Tau protects against Alzheimer's disease through amelioration of Tau-mediated lysosomal stress.

靶向自噬清除 Tau 蛋白可减轻 Tau 蛋白介导的溶酶体应激，从而预防阿尔茨海默病

Yoon Bo Hyun, Kim Jinho, Sengupta Sandip, Park Chan-Jung, Ko Minjoo, Kang Ji Hee, Ko Young Tag, Kim Yeji, Lim Seung Min, Bae Yoonhee, Choi MooYoung, Jang Yunyeong, Kwon Ho Jeong, Son Hyo Jin, Kim Hee Jin, Sim Taebo, Chang Keun-A, Lee Myung-Shik

免疫/内分泌

自噬

发表日期：2025

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Recent progress in emerging molecular targeted therapies for intrahepatic cholangiocarcinoma

肝内胆管癌分子靶向治疗的最新进展

期刊:RSC Medicinal Chemistry

影响因子:3.6

doi:10.1039/d4md00881b

Kim, Younghoon; Song, Jaewon; Kim, Namkyoung; Sim, Taebo

Site-specific mutagenesis screening in KRASG12D mutant library to uncover resistance mechanisms to KRASG12D inhibitors

KRASG12D 突变体库中的定点诱变筛选，揭示对 KRASG12D 抑制剂的耐药机制

期刊:Cancer Letters

影响因子:9.1

doi:10.1016/j.canlet.2024.216904

Jeesoo Choi, Ju-Young Shin, Taeyul K Kim, Kiwook Kim, Jiyun Kim, Eunhye Jeon, Juyeong Park, Yoon Dae Han, Kyung-A Kim, Taebo Sim, Hui Kwon Kim, Han Sang Kim

信号转导

发表日期：2024

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A novel NLRP3 inhibitor as a therapeutic agent against monosodium urate-induced gout

一种新型 NLRP3 抑制剂作为治疗单钠尿酸盐诱发痛风的药物

期刊:Frontiers in Immunology

影响因子:5.7

doi:10.3389/fimmu.2023.1307739

Kihyoun Park, Injae Shin, Yoonseon Kim, Hyereen Kang, Soo-Jin Oh, Eunkyeong Jang, Taebo Sim, Jeehee Youn, Myung-Shik Lee

Targeted kinase degradation via the KLHDC2 ubiquitin E3 ligase

通过 KLHDC2 泛素 E3 连接酶进行靶向激酶降解

期刊:Cell Chemical Biology

影响因子:6.6

doi:10.1016/j.chembiol.2023.07.008

Younghoon Kim, Pooreum Seo, Eunhye Jeon, Inchul You, Kyubin Hwang, Namkyoung Kim, Jason Tse, Juhyeon Bae, Ha-Soon Choi, Stephen M Hinshaw, Nathanael S Gray, Taebo Sim

Actin

发表日期：2023

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AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis

AK2 是肿瘤发生过程中 BRAF 的 AMP 感应负调节剂

期刊:Cell Death & Disease

影响因子:8.1

doi:10.1038/s41419-022-04921-7

Hyunjoo Kim #, Muhah Jeong #, Do-Hyeong Na, Shin-Hyeon Ryu, Eun Il Jeong, Kwangmin Jung, Jaemin Kang, Ho-June Lee, Taebo Sim, Dae-Yeul Yu, Hee Chul Yu, Baik-Hwan Cho, Yong-Keun Jung

Identification of highly selective type II kinase inhibitors with chiral peptidomimetic tails

具有手性肽模拟物尾的高选择性 II 型激酶抑制剂的鉴定

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry

影响因子:5.6

doi:10.1080/14756366.2022.2068148

Seo-Jung Han, Jae Eun Jung, Do Hee Oh, Minsup Kim, Jae-Min Kim, Kyung-Sook Chung, Hee-Soo Han, Jeong-Hun Lee, Kyung-Tae Lee, Hee Jin Jeong, In Ho Park, Eunkyeong Jeon, Jeon-Soo Shin, Dongkeun Hwang, Art E Cho, Duck-Hyung Lee, Taebo Sim

信号转导

发表日期：2022

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Combination of Type I and Type II MET Tyrosine Kinase Inhibitors as Therapeutic Approach to Prevent Resistance

联合使用 I 型和 II 型 MET 酪氨酸激酶抑制剂作为预防耐药性的治疗方法

期刊:Molecular Cancer Therapeutics

影响因子:5.3

doi:10.1158/1535-7163.MCT-21-0344

Magda Bahcall, Cloud P Paweletz, Yanan Kuang, Luke J Taus, Taebo Sim, Nam Doo Kim, Kshiti H Dholakia, Christie J Lau, Prafulla C Gokhale, Pratik R Chopade, Fangxin Hong, Zihan Wei, Jens Köhler, Paul T Kirschmeier, Jiannan Guo, Sujuan Guo, Stephen Wang, Pasi A Jänne

Anti-cancer effects of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one derivatives on hepatocellular carcinoma harboring FGFR4 activation

3,4-二氢嘧啶并[4,5-d]嘧啶-2(1H)-酮衍生物对FGFR4活化肝细胞癌的抗癌作用

期刊:Neoplasia

影响因子:

doi:10.1016/j.neo.2021.11.011

Yunju Nam, Injae Shin, Younghoon Kim, SeongShick Ryu, Namdoo Kim, Eunhye Ju, Taebo Sim

PHI-501, a dual inhibitor of RAF and DDR1/2, overcomes MAPK drug resistance in Melanoma

PHI-501 是一种 RAF 和 DDR1/2 双重抑制剂，可克服黑色素瘤中的 MAPK 药物耐药性。

Targeted autophagic clearance of Tau protects against Alzheimer's disease through amelioration of Tau-mediated lysosomal stress.

靶向自噬清除 Tau 蛋白可减轻 Tau 蛋白介导的溶酶体应激，从而预防阿尔茨海默病

Recent progress in emerging molecular targeted therapies for intrahepatic cholangiocarcinoma

肝内胆管癌分子靶向治疗的最新进展

Site-specific mutagenesis screening in KRASG12D mutant library to uncover resistance mechanisms to KRASG12D inhibitors

KRASG12D 突变体库中的定点诱变筛选，揭示对 KRASG12D 抑制剂的耐药机制

A novel NLRP3 inhibitor as a therapeutic agent against monosodium urate-induced gout

一种新型 NLRP3 抑制剂作为治疗单钠尿酸盐诱发痛风的药物

Targeted kinase degradation via the KLHDC2 ubiquitin E3 ligase

通过 KLHDC2 泛素 E3 连接酶进行靶向激酶降解

AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis

AK2 是肿瘤发生过程中 BRAF 的 AMP 感应负调节剂

Identification of highly selective type II kinase inhibitors with chiral peptidomimetic tails

具有手性肽模拟物尾的高选择性 II 型激酶抑制剂的鉴定

Combination of Type I and Type II MET Tyrosine Kinase Inhibitors as Therapeutic Approach to Prevent Resistance

联合使用 I 型和 II 型 MET 酪氨酸激酶抑制剂作为预防耐药性的治疗方法

Anti-cancer effects of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one derivatives on hepatocellular carcinoma harboring FGFR4 activation

3,4-二氢嘧啶并[4,5-d]嘧啶-2(1H)-酮衍生物对FGFR4活化肝细胞癌的抗癌作用