Effectiveness of mucoactives (carbocisteine and hypertonic saline) in addition to usual airway clearance management with usual airway clearance management alone in acute respiratory failure (MARCH): study protocol for a multi-centre 2x2 factorial, randomised, controlled, open-label, Phase 3, pragmatic, clinical and cost-effectiveness trial with internal pilot
在急性呼吸衰竭中，黏液活性剂（卡泊西汀和高渗盐水）联合常规气道清除治疗与单独使用常规气道清除治疗的疗效比较（MARCH）：一项多中心、2×2析因、随机、对照、开放标签、3期、实用性、临床和成本效益试验的研究方案，包含内部试点研究。
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doi:10.3310/nihropenres.13905.1
Connolly, Bronwen; Dickson, Naomi; Agus, Ashley; Blackwood, Bronagh; Borthwick, Mark; Bradley, Judy; Campbell, Christina; Chikhani, Marc; Clarke, Mike; Dark, Paul; Lall, Ranjit; McDowell, Cliona; McFarland, Margaret; McKelvey, Michael; O'Kane, Cecilia; O'Neill, Brenda; Perkins, Gavin; Shyamsundar, Murali; Sturmey, Gordon; Taggart, Clifford C; Warburton, John; Williams, Barry; McAuley, Daniel F
