日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of functional genetic components modulating toxicity response to PFOS using genome-wide CRISPR screens in HepG2/C3A cells

利用HepG2/C3A细胞中的全基因组CRISPR筛选,鉴定调控PFOS毒性反应的功能性遗传成分。

Kim, Chanhee; Tagmount, Abderrahmane; Zhu, Zhaohan; Wilson, Frances; Li, Danmeng; Ostrov, David A; Brad Barbazuk, William; Bacher, Rhonda; Vulpe, Chris D

Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide response modulators associated with outcomes in pediatric AML.

全基因组 CRISPR/Cas9 筛选鉴定出与儿童急性髓系白血病 (AML) 预后相关的 AraC-柔红霉素-依托泊苷反应调节剂

Nguyen Nam H K, Rafiee Roya, Parcha Phani K, Tagmount Abderrahmane, Rubnitz Jeffrey, Ribeiro Raul, Cao Xueyuan, Pounds Stanley B, Vulpe Christopher D, Lamba Jatinder K

Physiologically Relevant 3D CRISPR Screening Enhances Mechanistic Insight into Chemical Toxicity Compared to 2D Screening

与二维筛选相比,生理相关的三维 CRISPR 筛选能够增强对化学毒性机制的理解。

Kim, Chanhee; Zhu, Zhaohan; Tagmount, Abderrahmane; Barbazuk, W Brad; Bacher, Rhonda; Vulpe, Christopher D

Identification of Functional Genetic Components Modulating Toxicity Response to PFOS using Genome-wide CRISPR Screens in HepG2/C3A cells

利用HepG2/C3A细胞中的全基因组CRISPR筛选鉴定调控PFOS毒性反应的功能性遗传成分

Kim, Chanhee; Tagmount, Abderrahmane; Zhu, Zhaohan; Wilson, Frances; Li, Danmeng; Ostrov, David A; Barbazuk, W Brad; Bacher, Rhonda; Vulpe, Chris D

Characterizing common loss-of-function genes and their potential utility in assessing population variability and chemical susceptibility

鉴定常见功能丧失基因及其在评估群体变异性和化学敏感性方面的潜在用途

Kim, Chanhee; Zhu, Zhaohan; Tagmount, Abderrahmane; Barbazuk, W Brad; Bacher, Rhonda; Stuchal, Leah D; Martyniuk, Christopher J; Vulpe, Christopher D

Genome-wide CRISPR/Cas9 screen identifies etoposide response modulators associated with clinical outcomes in pediatric AML

全基因组 CRISPR/Cas9 筛选确定与儿童 AML 临床结果相关的依托泊苷反应调节剂

Nam H K Nguyen, Roya Rafiee, Abderrahmane Tagmount, Amin Sobh, Alex Loguinov, Angelica K de Jesus Sosa, Abdelrahman H Elsayed, Mohammed Gbadamosi, Nathan Seligson, Christopher R Cogle, Jeffery Rubnitz, Raul Ribeiro, James Downing, Xueyuan Cao, Stanley B Pounds, Christopher D Vulpe, Jatinder K Lamba

Genome-scale CRISPR screens identify host factors that promote human coronavirus infection

基因组规模的 CRISPR 筛选可识别促进人类冠状病毒感染的宿主因素

Marco Grodzki, Andrew P Bluhm, Moritz Schaefer, Abderrahmane Tagmount, Max Russo, Amin Sobh, Roya Rafiee, Chris D Vulpe, Stephanie M Karst, Michael H Norris

Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL-Specific Degrader DT2216

使用 BCL-XL 特异性降解剂 DT2216 克服胰腺癌的吉西他滨耐药性

Dinesh Thummuri #, Sajid Khan #, Patrick W Underwood #, Peiyi Zhang, Janet Wiegand, Xuan Zhang, Vivekananda Budamagunta, Amin Sobh, Abderrahmane Tagmount, Alexander Loguinov, Andrea N Riner, Ashwin S Akki, Elizabeth Williamson, Robert Hromas, Christopher D Vulpe, Guangrong Zheng, Jose G Trevino, Dao

Genome-wide CRISPR Screen Reveal Targets of Chiral Gold(I) Anticancer Compound in Mammalian Cells

全基因组 CRISPR 筛选揭示手性金(I)抗癌化合物在哺乳动物细胞中的靶点

Jong Hyun Kim, Samuel Ofori, Abderrahmane Tagmount, Chris D Vulpe, Samuel G Awuah

Applying genome-wide CRISPR to identify known and novel genes and pathways that modulate formaldehyde toxicity

应用全基因组 CRISPR 技术鉴定已知和新的调控甲醛毒性的基因和通路

Zhao, Yun; Wei, Linqing; Tagmount, Abderrahmane; Loguinov, Alex; Sobh, Amin; Hubbard, Alan; McHale, Cliona M; Chang, Christopher J; Vulpe, Chris D; Zhang, Luoping