日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of functional genetic components modulating toxicity response to PFOS using genome-wide CRISPR screens in HepG2/C3A cells

利用HepG2/C3A细胞中的全基因组CRISPR筛选,鉴定调控PFOS毒性反应的功能性遗传成分。

Kim, Chanhee; Tagmount, Abderrahmane; Zhu, Zhaohan; Wilson, Frances; Li, Danmeng; Ostrov, David A; Brad Barbazuk, William; Bacher, Rhonda; Vulpe, Chris D

Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide response modulators associated with outcomes in pediatric AML.

全基因组 CRISPR/Cas9 筛选鉴定出与儿童急性髓系白血病 (AML) 预后相关的 AraC-柔红霉素-依托泊苷反应调节剂

Nguyen Nam H K, Rafiee Roya, Parcha Phani K, Tagmount Abderrahmane, Rubnitz Jeffrey, Ribeiro Raul, Cao Xueyuan, Pounds Stanley B, Vulpe Christopher D, Lamba Jatinder K

Physiologically Relevant 3D CRISPR Screening Enhances Mechanistic Insight into Chemical Toxicity Compared to 2D Screening

与二维筛选相比,生理相关的三维 CRISPR 筛选能够增强对化学毒性机制的理解。

Kim, Chanhee; Zhu, Zhaohan; Tagmount, Abderrahmane; Barbazuk, W Brad; Bacher, Rhonda; Vulpe, Christopher D

Identification of Functional Genetic Components Modulating Toxicity Response to PFOS using Genome-wide CRISPR Screens in HepG2/C3A cells

利用HepG2/C3A细胞中的全基因组CRISPR筛选鉴定调控PFOS毒性反应的功能性遗传成分

Kim, Chanhee; Tagmount, Abderrahmane; Zhu, Zhaohan; Wilson, Frances; Li, Danmeng; Ostrov, David A; Barbazuk, W Brad; Bacher, Rhonda; Vulpe, Chris D

Characterizing common loss-of-function genes and their potential utility in assessing population variability and chemical susceptibility

鉴定常见功能丧失基因及其在评估群体变异性和化学敏感性方面的潜在用途

Kim, Chanhee; Zhu, Zhaohan; Tagmount, Abderrahmane; Barbazuk, W Brad; Bacher, Rhonda; Stuchal, Leah D; Martyniuk, Christopher J; Vulpe, Christopher D

Applying genome-wide CRISPR to identify known and novel genes and pathways that modulate formaldehyde toxicity

应用全基因组 CRISPR 技术鉴定已知和新的调控甲醛毒性的基因和通路

Zhao, Yun; Wei, Linqing; Tagmount, Abderrahmane; Loguinov, Alex; Sobh, Amin; Hubbard, Alan; McHale, Cliona M; Chang, Christopher J; Vulpe, Chris D; Zhang, Luoping

Crumpling of silver nanowires by endolysosomes strongly reduces toxicity

内溶酶体对银纳米线的褶皱作用可显著降低其毒性。

Lehmann, Sylvia G; Toybou, Djadidi; Pradas Del Real, Ana-Elena; Arndt, Devrah; Tagmount, Abderrahmane; Viau, Muriel; Safi, Malak; Pacureanu, Alexandra; Cloetens, Peter; Bohic, Sylvain; Salomé, Murielle; Castillo-Michel, Hiram; Omaña-Sanz, Brenda; Hofmann, Annette; Vulpe, Christopher; Simonato, Jean-Pierre; Celle, Caroline; Charlet, Laurent; Gilbert, Benjamin

Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity

功能分析揭示三氧化二砷细胞毒性的决定因素

Sobh, Amin; Loguinov, Alex; Yazici, Gulce Naz; Zeidan, Rola S; Tagmount, Abderrahmane; Hejazi, Nima S; Hubbard, Alan E; Zhang, Luoping; Vulpe, Chris D

Aerosol droplet delivery of mesoporous silica nanoparticles: A strategy for respiratory-based therapeutics

介孔二氧化硅纳米颗粒的气溶胶液滴递送:一种呼吸系统治疗策略

Li, Xueting; Xue, Min; Raabe, Otto G; Aaron, Holly L; Eisen, Ellen A; Evans, James E; Hayes, Fred A; Inaga, Sumire; Tagmount, Abderrahmane; Takeuchi, Minoru; Vulpe, Chris; Zink, Jeffrey I; Risbud, Subhash H; Pinkerton, Kent E

Silver nanowire exposure results in internalization and toxicity to Daphnia magna.

银纳米线暴露会导致大型蚤(Daphnia magna)内化并产生毒性

Scanlan Leona D, Reed Robert B, Loguinov Alexandre V, Antczak Philipp, Tagmount Abderrahmane, Aloni Shaul, Nowinski Daniel Thomas, Luong Pauline, Tran Christine, Karunaratne Nadeeka, Pham Don, Lin Xin Xin, Falciani Francesco, Higgins Christopher P, Ranville James F, Vulpe Chris D, Gilbert Benjamin