日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A scalable approach to resolving variants of uncertain significance

一种解决意义不确定变异的可扩展方法

Tejura, Malvika; Chen, Yile; McEwen, Abbye E; Stewart, Ross; Sverchkov, Yuriy; Laval, Florent; Woo, Ivan; Zeiberg, Daniel; Shen, Runxi; Fayer, Shawn; Stone, Jeremy; Smith, Nahum; Casadei, Silvia; Wang, Ziyu R; Snyder, Matthew W; Capodanno, Benjamin J; Gupta, Pankhuri; Benazouz, Mariam; Jain, Shantanu; Heidl, Sarah; Muffley, Lara; Dong, Shengcheng; Hitz, Benjamin C; Gabdank, Idan; Lin, Khine; Da, Estelle Y; Best, Sabrina; Grindstaff, Sally; Reinhart, David; Rodriguez-Salas, Leslie; Seid, Obsa; Vandi, Allyssa J; Wenman, Cameron; Wheelock, Melinda K; Pendyala, Sriram; Holmes, Dan; Xu, Alicia; Hosokai, Airi; Tixhon, Maxime; Reno, Chloe; Ewald, Jessica D; Spirohn-Fitzgerald, Kerstin; Teelucksingh, Tanisha; Hao, Tong; Chen, Zitong S; Haghighi, Marzieh; Hamid, Ahmad Kamal; Miglietta, Esteban A; Weisbart, Erin; Coppin, Georges; Lambourne, Luke; Gebbia, Marinella; Coté, Atina G; van Loggerenberg, Warren; Fawcett, Kirby M; Steiner, Robert D; Johnsen, Jill M; Stergachis, Andrew B; Iakoucheva, Lilia M; Singh, Shantanu; Cimini, Beth A; Roth, Frederick P; James, Richard G; Vidal, Marc; Taipale, Mikko; Carpenter, Anne E; Calderwood, Michael A; Craven, Mark; Pejaver, Vikas; Rubin, Alan F; Radivojac, Predrag; Fowler, Douglas M; Starita, Lea M

Comprehensively Testing the Function of Missense Variation in the STK11 Tumour Suppressor

全面检验STK11肿瘤抑制基因错义变异的功能

Zimmerman, Daniel; Cote, Atina; van Loggerenberg, Warren; Gebbia, Marinella; Kishore, Nishka; Weile, Jochen; Li, Roujia; Reno, Chloe; Marsh, Ashley Pl; Hernandez, Felicia; Shahagadkar, Preksha; Grove, Lauren; Meier, Samuel R; Wu, Hsin-Jung; Fenoglio, Silvia; Ahronian, Leanne; Teng, Teng; Waters, Andrew J; Seward, David; Taipale, Mikko; Aronson, Melyssa; Richardson, Marcy E; Adams, David J; Roth, Frederick P

Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways.

系统性地发现人类病原体和通路中的病原效应功能。

Pachano Tomas, Leng He, Dugied Guillaume, Tribble Travis, Loubiere Vincent, Rauh Felix, Lee Yeojin, Schleiffer Alexander, Young Veronika, Weller Benjamin, Lyons Eleanor A, Hass Matthew R, Kottayan Leah C, Weirauch Matthew T, Fuxman Bass Juan I, Newton Hayley J, Ensminger Alexander W, Braun Pascal Falter, Schramek Daniel, Stark Alexander, Taipale Mikko

Pathogenesis and transmission of SARS-CoV-2 D614G, Alpha, Gamma, Delta, and Omicron variants in golden hamsters.

SARS-CoV-2 D614G、Alpha、Gamma、Delta 和 Omicron 变种在金仓鼠中的致病性和传播

Banete Andra, Griffin Bryan D, Corredor Juan C, Chien Emily, Yip Lily, Gunawardena Tarini N A, Nirmalarajah Kuganya, Liang Jady, Lee Yaejin, Leacy Alexander, Pagliarani Sara, de Borja Richard, Yim Winfield, Lee Hunsang, Onodera Yu, Aftanas Patryk, Budylowski Patrick, Ahn Sang Kyun, Pei Yanlong, Ouyang Hong, Kent Laura, Li Xinliu Angel, Ostrowski Mario A, Kozak Robert A, Wootton Sarah K, Christie-Holmes Natasha, Gray-Owen Scott D, Taipale Mikko, Simpson Jared T, Maguire Finlay, McGeer Allison J, Zhang Haibo, Susta Leonardo, Moraes Theo J, Mubareka Samira

Pervasive mislocalization of pathogenic coding variants underlying human disorders.

人类疾病致病编码变异的普遍错误定位

Lacoste Jessica, Haghighi Marzieh, Haider Shahan, Reno Chloe, Lin Zhen-Yuan, Segal Dmitri, Qian Wesley Wei, Xiong Xueting, Teelucksingh Tanisha, Miglietta Esteban, Shafqat-Abbasi Hamdah, Ryder Pearl V, Senft Rebecca, Cimini Beth A, Murray Ryan R, Nyirakanani Chantal, Hao Tong, McClain Gregory G, Roth Frederick P, Calderwood Michael A, Hill David E, Vidal Marc, Yi S Stephen, Sahni Nidhi, Peng Jian, Gingras Anne-Claude, Singh Shantanu, Carpenter Anne E, Taipale Mikko

An HSF1-JMJD6-HSP feedback circuit promotes cell adaptation to proteotoxic stress

HSF1-JMJD6-HSP反馈回路促进细胞适应蛋白毒性应激

Alasady, Milad J; Koeva, Martina; Takagishi, Seesha R; Segal, Dmitri; Amici, David R; Smith, Roger S; Ansel, Daniel J; Lindquist, Susan; Whitesell, Luke; Bartom, Elizabeth T; Taipale, Mikko; Mendillo, Marc L

Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci

肉瘤中反复发生的染色体易位形成巨型复合物,导致 NuA4/TIP60 错误定位到 Polycomb 靶位点。

Sudarshan, Deepthi; Avvakumov, Nikita; Lalonde, Marie-Eve; Alerasool, Nader; Joly-Beauparlant, Charles; Jacquet, Karine; Mameri, Amel; Lambert, Jean-Philippe; Rousseau, Justine; Lachance, Catherine; Paquet, Eric; Herrmann, Lara; Thonta Setty, Samarth; Loehr, Jeremy; Bernardini, Marcus Q; Rouzbahman, Marjan; Gingras, Anne-Claude; Coulombe, Benoit; Droit, Arnaud; Taipale, Mikko; Doyon, Yannick; Côté, Jacques

A conformational switch driven by phosphorylation regulates the activity of the evolutionarily conserved SNARE Ykt6

磷酸化驱动的构象转换调节进化上保守的SNARE蛋白Ykt6的活性。

McGrath, Kaitlyn; Agarwal, Shivani; Tonelli, Marco; Dergai, Mykola; Gaeta, Anthony L; Shum, Andrew K; Lacoste, Jessica; Zhang, Yongbo; Wen, Wenyu; Chung, Daayun; Wiersum, Grant; Shevade, Aishwarya; Zaichick, Sofia; van Rossum, Damian B; Shuvalova, Ludmilla; Savas, Jeffrey N; Kuchin, Sergei; Taipale, Mikko; Caldwell, Kim A; Caldwell, Guy A; Fasshauer, Dirk; Caraveo, Gabriela

A Comprehensive, Flexible Collection of SARS-CoV-2 Coding Regions

一套全面、灵活的SARS-CoV-2编码区集合

Kim, Dae-Kyum; Knapp, Jennifer J; Kuang, Da; Chawla, Aditya; Cassonnet, Patricia; Lee, Hunsang; Sheykhkarimli, Dayag; Samavarchi-Tehrani, Payman; Abdouni, Hala; Rayhan, Ashyad; Li, Roujia; Pogoutse, Oxana; Coyaud, Étienne; van der Werf, Sylvie; Demeret, Caroline; Gingras, Anne-Claude; Taipale, Mikko; Raught, Brian; Jacob, Yves; Roth, Frederick P

Function, evolution, and structure of J-domain proteins

J结构域蛋白的功能、进化和结构

Kampinga, Harm H; Andreasson, Claes; Barducci, Alessandro; Cheetham, Michael E; Cyr, Douglas; Emanuelsson, Cecilia; Genevaux, Pierre; Gestwicki, Jason E; Goloubinoff, Pierre; Huerta-Cepas, Jaime; Kirstein, Janine; Liberek, Krzysztof; Mayer, Matthias P; Nagata, Kazuhiro; Nillegoda, Nadinath B; Pulido, Pablo; Ramos, Carlos; De Los Rios, Paolo; Rospert, Sabine; Rosenzweig, Rina; Sahi, Chandan; Taipale, Mikko; Tomiczek, Bratłomiej; Ushioda, Ryo; Young, Jason C; Zimmermann, Richard; Zylicz, Alicja; Zylicz, Maciej; Craig, Elizabeth A; Marszalek, Jaroslaw