日期:
2020 年 — 2026 年
2020
2021
2022
2023
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2025
2026
影响因子:

Protective PLCG2 variants associate with a delayed onset of Alzheimer's disease among heterozygous APOE ε4 carriers

PLCG2保护性变异与APOE ε4杂合子携带者阿尔茨海默病发病延迟相关

Jeskanen, Heli; Heikkinen, Sami; Kervinen, Inka; Lehtisalo, Jenni; Ngandu, Tiia; Willman, Roosa-Maria; Rosa, Jessica; Hoffmann, Dorit; Leinonen, Ville; Haapasalo, Annakaisa; Takalo, Mari; Martiskainen, Henna; Hiltunen, Mikko

Genetic validation of ABI3 p.Ser209Phe variant and its effects on early brain pathology in asymptomatic elderly individuals

ABI3 p.Ser209Phe 变异的遗传验证及其对无症状老年人早期脑部病理的影响

Koivumäki, Mikko; Martiskainen, Henna; Takalo, Mari; Lehtisalo, Jenni; Ngandu, Tiia; Snellman, Anniina; Hiltunen, Mikko; Rinne, Juha O

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks.

非小胶质细胞中 PLCG2 的下调会损害突触功能,并引发阿尔茨海默病相关的特征。

Coulon Audrey, Rabiller Florian, Takalo Mari, Roy Avishek, Pelletier Alexandre, Martiskainen Henna, Siedlecki-Wullich Dolores, Lannette-Weimann Nina, Majerníková Nad'a, Grenon Arthur, Gao Vance, Erhardt Anaël, Pernodet Anne, Lemaire Morgane, Limoge Floriane, Walle Pauline, Mendes Tiago, Guyot Karine, Lemeu Célia, Carvalho Lukas-Iohan, de Farias Ana Raquel Melo, Hulsman Marc, Najdek Chloé, Freire-Regatillo Alejandra, Saha Orthis, Amouyel Philippe, Charbonnier Camille, Deleuze Jean-François, Dols-Icardo Orio, Jeskanen Heli, Willman Roosa-Maria, Kuulasmaa Teemu, Kurki Mitja, Hardy John, Heikkinen Sami, Holstege Henne, Mäkinen Petra, Nicolas Gaël, Mead Simon, Wagner Michael, Ramirez Alfredo, Rauramaa Tuomas, Palotie Aarno, Sims Rebecca, Soininen Hilkka, van Swieten John, Williams Julie, Bellenguez Céline, Gelle Carla, Lambert Erwan, Costa Marcos R, Tcw Julia, Glaab Enrico, Ayral Anne-Marie, Demiautte Florie, Grenier-Boley Benjamin, Muntaner Manon, Eberlé Delphine, Deforges Séverine, Haas Joel, Kilinc Devrim, Mulle Christophe, Chapuis Julien, Hiltunen Mikko, Dumont Julie, Lambert Jean-Charles

A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's disease

一种小的TAT-TrkB肽可阻止BDNF受体裂解,并恢复阿尔茨海默病患者的突触生理功能。

Fonseca-Gomes, João; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H; Alemãn-Serrano, Nuno; Atalaia-Barbacena, Henrique; Ribeiro-Rodrigues, Leonor; Ramalho, Rita M; Pinto, Rui; Miranda, Hugo Vicente; Tanqueiro, Sara R; de Almeida-Borlido, Carolina; Ramalho, Maria João; Miranda-Lourenço, Catarina; Belo, Rita F; Ferreira, Catarina B; Neves, Vera; Rombo, Diogo M; Viais, Ricardo; Umemori, Juzoh; Martins, Ivo C; Jerónimo-Santos, André; Caetano, António; Manso, Nuno; Mäkinen, Petra; Marttinen, Mikael; Takalo, Mari; Bremang, Michael; Pike, Ian; Haapasalo, Annakaisa; Loureiro, Joana A; Pereira, Maria Carmo; Santos, Nuno C; Outeiro, Tiago F; Castanho, Miguel A R B; Fernandes, Adelaide; Hiltunen, Mikko; Duarte, Carlos B; Castrén, Eero; de Mendonça, Alexandre; Sebastião, Ana M; Rodrigues, Tiago M; Diógenes, Maria José

Correction to: Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

更正:阿尔茨海默病遗传风险因子FERMT2(Kindlin-2)以APP依赖的方式控制轴突生长和突触可塑性

Eysert, Fanny; Coulon, Audrey; Boscher, Emmanuelle; Vreulx, Anaїs-Camille; Flaig, Amandine; Mendes, Tiago; Hughes, Sandrine; Grenier-Boley, Benjamin; Hanoulle, Xavier; Demiautte, Florie; Bauer, Charlotte; Marttinen, Mikael; Takalo, Mari; Amouyel, Philippe; Desai, Shruti; Pike, Ian; Hiltunen, Mikko; Chécler, Frédéric; Farinelli, Mélissa; Delay, Charlotte; Malmanche, Nicolas; Hébert, Sébastien S; Dumont, Julie; Kilinc, Devrim; Lambert, Jean-Charles; Chapuis, Julien

Decreased plasma C-reactive protein levels in APOE ε4 allele carriers.

APOE α4 等位基因携带者血浆 C 反应蛋白水平降低

Martiskainen Henna, Takalo Mari, Solomon Alina, Stančáková Alena, Marttinen Mikael, Natunen Teemu, Haapasalo Annakaisa, Herukka Sanna-Kaisa, Kuusisto Johanna, Soininen Hilkka, Kivipelto Miia, Laakso Markku, Hiltunen Mikko

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer's Disease

阿尔茨海默病中突触毒性和神经炎症的分子机制

Marttinen, Mikael; Takalo, Mari; Natunen, Teemu; Wittrahm, Rebekka; Gabbouj, Sami; Kemppainen, Susanna; Leinonen, Ville; Tanila, Heikki; Haapasalo, Annakaisa; Hiltunen, Mikko

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.

DHCR24 对炎症引起的神经元死亡具有神经保护作用

Martiskainen Henna, Paldanius Kaisa M A, Natunen Teemu, Takalo Mari, Marttinen Mikael, Leskelä Stina, Huber Nadine, Mäkinen Petra, Bertling Enni, Dhungana Hiramani, Huuskonen Mikko, Honkakoski Paavo, Hotulainen Pirta, Rilla Kirsi, Koistinaho Jari, Soininen Hilkka, Malm Tarja, Haapasalo Annakaisa, Hiltunen Mikko