日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Impact of Single Halogen Atom Substitutions on Antiviral Profile of Inhibitors Targeting SARS-CoV‑2 Main Protease

单个卤素原子取代对靶向SARS-CoV-2主蛋白酶抑制剂抗病毒活性的影响

Bulut, Haydar; Higashi-Kuwata, Nobuyo; Ogata-Aoki, Hiromi; Hayashi, Hironori; Takamune, Nobutoki; Kishimoto, Naoki; Das, Debananda; Li, Mi; Wlodawer, Alexander; Misumi, Shogo; Tamamura, Hirokazu; Mitsuya, Hiroaki

Targeting envelope lipids with 2,6‑di‑O‑methyl‑3‑acetyl‑β‑cyclodextrin impairs infectivity of SARS‑CoV‑2 and Japanese encephalitis virus

利用2,6-二-O-甲基-3-乙酰基-β-环糊精靶向包膜脂质可削弱SARS-CoV-2和日本脑炎病毒的感染性

Kusakari, Daichi; Kishimoto, Naoki; Oshiro, Kazuyuki; Udeda, Yui; Takamune, Nobutoki; Motoyama, Keiichi; Misumi, Shogo

Structural and virologic mechanism of the emergence of resistance to M(pro) inhibitors in SARS-CoV-2

SARS-CoV-2 对 M(pro) 抑制剂产生耐药性的结构和病毒学机制

Hattori, Shin-Ichiro; Bulut, Haydar; Hayashi, Hironori; Kishimoto, Naoki; Takamune, Nobutoki; Hasegawa, Kazuya; Furusawa, Yuri; Yamayoshi, Seiya; Murayama, Kazutaka; Tamamura, Hirokazu; Li, Mi; Wlodawer, Alexander; Kawaoka, Yoshihiro; Misumi, Shogo; Mitsuya, Hiroaki

Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV

鉴定出一种新型长效4'-修饰核苷类逆转录酶抑制剂,用于对抗乙型肝炎病毒

Higashi-Kuwata, Nobuyo; Hayashi, Sanae; Kumamoto, Hiroki; Ogata-Aoki, Hiromi; Das, Debananda; Venzon, David; Hattori, Shin-Ichiro; Bulut, Haydar; Hashimoto, Mai; Otagiri, Masaki; Takamune, Nobutoki; Kishimoto, Naoki; Davis, David A; Misumi, Shogo; Kakuni, Masakazu; Tanaka, Yasuhito; Mitsuya, Hiroaki

Arginyl-tRNA-protein transferase 1 contributes to governing optimal stability of the human immunodeficiency virus type 1 core

精氨酰-tRNA-蛋白转移酶1有助于维持人类免疫缺陷病毒1型核心蛋白的最佳稳定性。

Kishimoto, Naoki; Okano, Ryosuke; Akita, Ayano; Miura, Satoshi; Irie, Ayaka; Takamune, Nobutoki; Misumi, Shogo

ATP generation in a host cell in early-phase infection is increased by upregulation of cytochrome c oxidase activity via the p2 peptide from human immunodeficiency virus type 1 Gag

在感染早期,宿主细胞内ATP的生成增加,这是由于人类免疫缺陷病毒1型Gag蛋白的p2肽上调细胞色素c氧化酶活性所致。

Ogawa, Minako; Takemoto, Yuki; Sumi, Shintaro; Inoue, Daisuke; Kishimoto, Naoki; Takamune, Nobutoki; Shoji, Shozo; Suzu, Shinya; Misumi, Shogo

Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir

HIV-1蛋白酶的二聚化过程分为两个步骤,这与达芦那韦抑制蛋白酶二聚化的机制有关。

Hayashi, Hironori; Takamune, Nobutoki; Nirasawa, Takashi; Aoki, Manabu; Morishita, Yoshihiko; Das, Debananda; Koh, Yasuhiro; Ghosh, Arun K; Misumi, Shogo; Mitsuya, Hiroaki

Clearly different mechanisms of enhancement of short-lived Nef-mediated viral infectivity between SIV and HIV-1

SIV 和 HIV-1 之间增强短寿命 Nef 介导的病毒感染性的机制显然不同。

Harada, Keisuke; Takamune, Nobutoki; Shoji, Shozo; Misumi, Shogo

Royal jelly enhances antigen-specific mucosal IgA response

蜂王浆可增强抗原特异性黏膜IgA反应

Kai, Hikaru; Motomura, Yuji; Saito, Shiro; Hashimoto, Ken; Tatefuji, Tomoki; Takamune, Nobutoki; Misumi, Shogo

Central nervous system compartmentalization of HIV-1 subtype C variants early and late in infection in young children

在幼儿感染早期和晚期,HIV-1 C亚型变异株在中枢神经系统中的区室化分布

Sturdevant, Christa Buckheit; Dow, Anna; Jabara, Cassandra B; Joseph, Sarah B; Schnell, Gretja; Takamune, Nobutoki; Mallewa, Macpherson; Heyderman, Robert S; Van Rie, Annelies; Swanstrom, Ronald