日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An oral, liver-restricted LXR inverse agonist for dyslipidemia: preclinical development and phase 1 trial

一种用于治疗血脂异常的口服、肝脏限制性 LXR 反向激动剂:临床前开发和 I 期试验

Li, Xiaoxu; Benegiamo, Giorgia; Vijayakumar, Archana; Sroda, Natalie; Kimura, Masaki; Huss, Ryan S; Weng, Steve; Murakami, Eisuke; Kirby, Brian J; von Alvensleben, Giacomo V G; Kremoser, Claus; Gane, Edward J; Takebe, Takanori; Myers, Robert P; Subramanian, G Mani; Auwerx, Johan

Modeling immune lineage co-development in human pluripotent stem cell-derived liver organoids

利用人类多能干细胞衍生的肝脏类器官模拟免疫谱系共同发育

Rezvani, Milad; Quach, Susanna; Lewis, Kyle; Saiki, Norikazu; Xue, Chuqing; Kimura, Masaki; Iwasawa, Kentaro; Weihs, Julian; Elzobair, Tahlil; Al Reza, Hasan; Cai, Yuqi; Zhang, RanRan; Milton, Yuka; Chaturvedi, Praneet; Thorner, Konrad; Nayak, Ramesh C; Munera, Jorge; Kramer, Phillip; Davis, Brian R; Balamurugan, Appakalai N; Ahmed, Yeni Ait; Finke, Marcel; Behncke, Rose Yinghan; Guillot, Adrien; Hägerling, René; Polansky, Julia K; Bufler, Philip; Cancelas, Jose A; Zorn, Aaron M; Wells, James M; Yoshimoto, Momoko; Takebe, Takanori

Reversal of ACLF and ALF using whole blood extracorporeal system combining HLA-depleted liver organoids with granulocyte-monocyte apheresis

利用全血体外循环系统结合去除HLA的肝脏类器官和粒细胞-单核细胞分离术逆转急性肝衰竭(ACLF)和急性肝衰竭(ALF)。

Yamaguchi, Hitomi; Yoneyama, Yosuke; Ichimura, Kentaro; Ohtsu, Kanae; Soen, Mika; Moriya, Chiharu; Kumagai, Maki; Myers, Robert P; Subramanian, G Mani; Takebe, Takanori

Investigating the oncogenic role of aberrant EZH2 in hepatoblastoma

研究异常 EZH2 在肝母细胞瘤中的致癌作用

Glaser, Kathryn; DePasquale, Erica A K; Berklite, Lara; Hickner, Brian T; Rao, Priyanka; Patel, Roma H; Badachhape, Andrew A; Roy, Somak; Schepers, Emily; Timchenko, Nikolai A; Geller, James I; Ranganathan, Sarangarajan; Tiao, Gregory M; Aronow, Bruce; Takebe, Takanori; Woodfield, Sarah E; Vasudevan, Sanjeev A; Bondoc, Alexander J

Modeling Transmembrane 6 Superfamily Member 2 p.Glu167Lys-associated Steatotic Liver Disease Using Androgen-treated Human Induced Pluripotent Stem Cell-derived Hepatocyte-like Cells

利用雄激素处理的人类诱导多能干细胞衍生的肝细胞样细胞模拟跨膜6超家族成员2 p.Glu167Lys相关脂肪肝疾病

Hirai, Asei; Yoneyama, Yosuke; Assi, Ismael; Osonoi, Sho; Sakai, Sosuke; Ohtsu, Kanae; Takebe, Takanori

Multi-zonal liver organoids from human pluripotent stem cells.

利用人类多能干细胞构建的多区域肝脏类器官。

Reza Hasan Al, Santangelo Connie, Iwasawa Kentaro, Reza Abid Al, Sekiya Sachiko, Glaser Kathryn, Bondoc Alexander, Merola Jonathan, Takebe Takanori

Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids.

中胚层和内胚层的共同发育使得肺和肠道类器官能够形成器官型血管。

Miao Yifei, Pek Nicole M, Tan Cheng, Jiang Cheng, Yu Zhiyun, Iwasawa Kentaro, Shi Min, Kechele Daniel O, Sundaram Nambirajan, Pastrana-Gomez Victor, Sinner Debora I, Liu Xingchen, Lin Ko Chih, Na Cheng-Lun, Kishimoto Keishi, Yang Min-Chi, Maharjan Sushila, Tchieu Jason, Whitsett Jeffrey A, Zhang Yu Shrike, McCracken Kyle W, Rottier Robbert J, Kotton Darrell N, Helmrath Michael A, Wells James M, Takebe Takanori, Zorn Aaron M, Chen Ya-Wen, Guo Minzhe, Gu Mingxia

ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH.

ACMSD 抑制剂可纠正 MASLD/MASH 中的纤维化、炎症和 DNA 损伤

Liu Yasmine J, Kimura Masaki, Li Xiaoxu, Sulc Jonathan, Wang Qi, Rodríguez-López Sandra, Scantlebery Angelique M L, Strotjohann Keno, Gallart-Ayala Hector, Vijayakumar Archana, Myers Robert P, Ivanisevic Julijana, Houtkooper Riekelt H, Subramanian G Mani, Takebe Takanori, Auwerx Johan

Autologous Organoid-T Cell Co-Culture Platform for Modeling of Immune-Mediated Drug-Induced Liver Injury

自体类器官-T细胞共培养平台用于模拟免疫介导的药物性肝损伤

Soussi, Fadoua El Abdellaoui; Brusilovsky, Michael; Buck, Emma; Bacon, W Clark; Dadgar, Sina; Fullerton, Aaron; Durban, Victoria Marsh; Barrile, Riccardo; Helmrath, Michael A; Takebe, Takanori; Roth, Adrian; Kasendra, Magdalena

Life-supporting functional kidney replacement by integration of embryonic metanephros-bladder composite tissue transplants

通过整合胚胎后肾-膀胱复合组织移植实现维持生命的肾脏功能性替代

Kinoshita, Yoshitaka; Kobayashi, Eiji; Matsui, Kenji; Inage, Yuka; Morimoto, Keita; Yamamoto, Shutaro; Iwai, Satomi; Kitada, Kento; Iwasawa, Kentaro; Saito, Yatsumu; Fujimoto, Toshinari; Matsumoto, Kei; Nagamori, Shushi; Nishiyama, Akira; Kume, Haruki; Takebe, Takanori; Yokoo, Takashi; Yamanaka, Shuichiro