Neuromodulatory effect of Gαs- or Gαq-coupled G-protein-coupled receptor on NMDA receptor selectively activates the NMDA receptor/Ca2+/calcineurin/cAMP response element-binding protein-regulated transcriptional coactivator 1 pathway to effectively induce brain-derived neurotrophic factor expression in neurons
Gαs或Gαq偶联的G蛋白偶联受体对NMDA受体的神经调节作用，选择性地激活NMDA受体/Ca2+/钙调磷酸酶/cAMP反应元件结合蛋白调节的转录共激活因子1通路，从而有效诱导神经元中脑源性神经营养因子的表达。
期刊:Journal of Neuroscience
影响因子:4
doi:10.1523/JNEUROSCI.3650-14.2015
Fukuchi, Mamoru; Tabuchi, Akiko; Kuwana, Yuki; Watanabe, Shinjiro; Inoue, Minami; Takasaki, Ichiro; Izumi, Hironori; Tanaka, Ayumi; Inoue, Ran; Mori, Hisashi; Komatsu, Hidetoshi; Takemori, Hiroshi; Okuno, Hiroyuki; Bito, Haruhiko; Tsuda, Masaaki
信号转导
神经科学
GPCR/Calcium/cAMP
