日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Complement Activation by an Anti-Dengue/Zika Antibody with Impaired Fcγ Receptor Binding Provides Strong Efficacy and Abrogates Risk of Antibody-Dependent Enhancement

抗登革热/寨卡病毒抗体与 Fcγ 受体结合受损时,其补体激活具有很强的疗效,并消除了抗体依赖性增强的风险

Zenjiro Sampei, Christine Xing'er Koo, Frannie Jiuyi Teo, Ying Xiu Toh, Taku Fukuzawa, Siok Wan Gan, Takeru Nambu, Adrian Ho, Kiyofumi Honda, Tomoyuki Igawa, Fariyal Ahmed, Cheng-I Wang, Katja Fink, Junichi Nezu

Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering

结合 pH 依赖性抗原结合和新型 Fc 工程消除食蟹猴血浆可溶性抗原

Yuji Hori, Ken Ohmine, Hitoshi Katada, Yuki Noguchi, Kazuki Sato, Takeru Nambu, Lam Runyi Adeline, Gan Siok Wan, Kenta Haraya, Kazuhisa Ozeki, Masahiko Nanami, Tatsuhiko Tachibana, Zenjiro Sampei, Taichi Kuramochi, Junichi Nezu, Kunihiro Hattori, Tomoyuki Igawa

Comprehensive engineering of a therapeutic neutralizing antibody targeting SARS-CoV-2 spike protein to neutralize escape variants

针对SARS-CoV-2刺突蛋白,对治疗性中和抗体进行全面工程改造,以中和逃逸变异株

Taichi Kuramochi ,Siok Wan Gan ,Adrian W S Ho ,Bei Wang ,Nagisa Kageji, Takeru Nambu ,Sayaka Iida ,Momoko Okuda-Miura ,Wei Shan Chia ,Chiew Ying Yeo ,Dan Chen ,Wen-Hsin Lee ,Eve Zi Xian Ngoh ,Siti Nazihah Mohd Salleh ,Cheng-I Wang ,Tomoyuki Igawa ,Hideaki Shimada

Identification of human IgG1 variant with enhanced FcRn binding and without increased binding to rheumatoid factor autoantibody

鉴定出与 FcRn 结合增强且与类风湿因子自身抗体结合不增强的人类 IgG1 变体

Atsuhiko Maeda, Yuki Iwayanagi, Kenta Haraya, Tatsuhiko Tachibana, Genki Nakamura, Takeru Nambu, Keiko Esaki, Kunihiro Hattori, Tomoyuki Igawa

Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases

SKY59是一种新型循环抗体,它能持久中和C5,这为补体介导疾病提供了一种潜在的治疗方法。

Taku Fukuzawa ,Zenjiro Sampei ,Kenta Haraya ,Yoshinao Ruike ,Meiri Shida-Kawazoe ,Yuichiro Shimizu ,Siok Wan Gan ,Machiko Irie ,Yoshinori Tsuboi ,Hitoshi Tai ,Tetsushi Sakiyama ,Akihisa Sakamoto ,Shinya Ishii ,Atsuhiko Maeda ,Yuki Iwayanagi ,Norihito Shibahara ,Mitsuko Shibuya ,Genki Nakamura ,Takeru Nambu ,Akira Hayasaka ,Futa Mimoto ,Yuu Okura ,Yuji Hori ,Kiyoshi Habu ,Manabu Wada ,Takaaki Miura ,Tatsuhiko Tachibana ,Kiyofumi Honda ,Hiroyuki Tsunoda ,Takehisa Kitazawa ,Yoshiki Kawabe ,Tomoyuki Igawa ,Kunihiro Hattori ,Junichi Nezu

Inhibitory FcγRIIb-Mediated Soluble Antigen Clearance from Plasma by a pH-Dependent Antigen-Binding Antibody and Its Enhancement by Fc Engineering

pH 依赖性抗原结合抗体抑制 FcγRIIb 介导的血浆可溶性抗原清除及其通过 Fc 工程增强

Yuki Iwayanagi, Tomoyuki Igawa, Atsuhiko Maeda, Kenta Haraya, Naoko A Wada, Norihito Shibahara, Ken Ohmine, Takeru Nambu, Genki Nakamura, Futa Mimoto, Hitoshi Katada, Shunsuke Ito, Tatsuhiko Tachibana, Kou-ichi Jishage, Kunihiro Hattori