Takeuchi Koh相关文献与解析，生知库 | 链接生命科学的每一步

Leveraging relaxation-optimized (1)H-(13)C(F) correlations in 4-(19)F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins

利用4-(19)F-苯丙氨酸中弛豫优化的(1)H-(13)C(F)相关性作为原子信标来探测大型蛋白质的结构和动力学

Boeszoermenyi, Andras; Radeva, Denitsa L; Schindler, Sebastian; Valadares, Veronica; Padmanabha Das, Krishna M; Dubey, Abhinav; Viennet, Thibault; Schmitt, Max; Kast, Peter; Gelev, Vladimir M; Stoyanov, Nikolay; Burdzhiev, Nikola; Petrov, Ognyan; Ficarro, Scott; Marto, Jarred; Geffken, Ezekiel A; Dhe-Paganon, Sirano; Seo, Hyuk-Soo; Alexander, Nathan D; Cooley, Richard B; Mehl, Ryan A; Kovacs, Helena; Anklin, Clemens; Bermel, Wolfgang; Kuprov, Ilya; Takeuchi, Koh; Arthanari, Haribabu

发表日期：2025

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Regulatory role of the N-terminal intrinsically disordered region of the DEAD-box RNA helicase DDX3X in selective RNA recognition.

DEAD-box RNA 解旋酶 DDX3X 的 N 端固有无序区在选择性 RNA 识别中的调控作用

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-62806-7

Toyama Yuki, Takeuchi Koh, Shimada Ichio

免疫/内分泌

发表日期：2025

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Bottom-up design of peptide shapes in water using oligomers of N-methyl-l/d-alanine

利用N-甲基-L/D-丙氨酸寡聚体在水中自下而上地设计肽的形状

期刊:Chemical Science

影响因子:7.4

doi:10.1039/d5sc01483b

Morimoto, Jumpei; Yokomine, Marin; Shiratori, Yota; Ueda, Takumi; Nakamuro, Takayuki; Takaba, Kiyofumi; Maki-Yonekura, Saori; Umezawa, Koji; Miyanishi, Koichiro; Fukuda, Yasuhiro; Watanabe, Takumu; Suga, Mayuko; Inayoshi, Ayumi; Yoshida, Takuya; Mizukami, Wataru; Takeuchi, Koh; Yonekura, Koji; Nakamura, Eiichi; Sando, Shinsuke

发表日期：2025

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Structural basis of the residence time of adenosine A(2A) receptor ligands revealed by NMR

核磁共振揭示腺苷A(2A)受体配体停留时间的结构基础

期刊:Chemical Science

影响因子:7.4

doi:10.1039/d5sc02398j

Ueda, Takumi; Tsuchida, Tomoki; Kurita, Masatoshi; Mizumura, Takuya; Imai, Shunsuke; Shiraishi, Yutaro; Kofuku, Yutaka; Miyakawa, Shuhei; Fukuzawa, Kaori; Takeuchi, Koh; Shimada, Ichio

信号转导

发表日期：2025

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Two-step target recognition for the competitive inhibition activity of an anti-VEGF aptamer

抗 VEGF 适体竞争性抑制活性的两步靶标识别

期刊:RNA

影响因子:5

doi:10.1261/rna.080524.125

Takeuchi, Koh; Ueda, Takumi; Imai, Misaki; Fujisaki, Miwa; Tsujimura, Masanari; Tokunaga, Yuji; Kofuku, Yutaka; Shimada, Ichio

IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope

癌症中的IMPDH和GTP代谢：机制、调控和转化应用

期刊:Cancer Science

影响因子:4.3

doi:10.1111/cas.70200

Ogawa-Iio, Aki; Takeuchi, Koh; Shigemi, Keita; Genoveso, Michelle Jane; Niitsu, Hiroaki; Koh, Iemasa; Ota, Yusei; Yamane, Keita; Hinoi, Takao; Osaka, Natsuki; Oshima, Masashi; Ishikawa, Tomohiro; Mizuno, Tomoyuki; Natsumeda, Manabu; Tateishi, Kensuke; Hashizume, Rintaro; Osuka, Satoru; Goyama, Susumu; Yasuda, Tomoharu; Senda, Toshiya; Sasaki, Atsuo T

PI5P4K inhibitors: promising opportunities and challenges

PI5P4K抑制剂：充满机遇与挑战

期刊:

影响因子:

doi:10.1111/febs.17393

Takeuchi, Koh; Nagase, Lisa; Kageyama, Shun; Kanoh, Hirotaka; Oshima, Masashi; Ogawa-Iio, Aki; Ikeda, Yoshiki; Fujii, Yuki; Kondo, Sei; Osaka, Natsuki; Masuda, Takeshi; Ishihara, Tsukasa; Nakamura, Yoshikazu; Hirota, Yoshihisa; Sasaki, Takehiko; Senda, Toshiya; Sasaki, Atsuo T

发表日期：2025

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A high-resolution structural characterization and physicochemical study of how a peptoid binds to an oncoprotein MDM2

肽类化合物与癌蛋白MDM2结合的高分辨率结构表征和理化研究

期刊:Chemical Science

影响因子:7.4

doi:10.1039/d4sc01540a

Yokomine, Marin; Morimoto, Jumpei; Fukuda, Yasuhiro; Ueda, Takumi; Takeuchi, Koh; Umezawa, Koji; Ago, Hideo; Matsuura, Hiroaki; Ueno, Go; Senoo, Akinobu; Nagatoishi, Satoru; Tsumoto, Kouhei; Sando, Shinsuke

A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion

高剂量KRP203诱导细胞质空泡形成，并伴有磷脂酰肌醇分离异常和内体扩张。

期刊:Biochemical and Biophysical Research Communications

影响因子:2.2

doi:10.1016/j.bbrc.2024.149981

Kofuji, Satoshi; Wolfe, Kara; Sumita, Kazutaka; Kageyama, Shun; Yoshino, Hirofumi; Hirota, Yoshihisa; Ogawa-Iio, Aki; Kanoh, Hirotaka; Sasaki, Mika; Kofuji, Kaori; Davis, Mindy I; Pragani, Rajan; Shen, Min; Boxer, Matthew B; Nakatsu, Fubito; Nigorikawa, Kiyomi; Sasaki, Takehiko; Takeuchi, Koh; Senda, Toshiya; Kim, Seong M; Edinger, Aimee L; Simeonov, Anton; Sasaki, Atsuo T

细胞生物学

发表日期：2024

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A minimal RNA-cleaving DNAzyme and its catalytic mechanism

一种最小的RNA切割DNA酶及其催化机制

Leveraging relaxation-optimized (1)H-(13)C(F) correlations in 4-(19)F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins

利用4-(19)F-苯丙氨酸中弛豫优化的(1)H-(13)C(F)相关性作为原子信标来探测大型蛋白质的结构和动力学

Regulatory role of the N-terminal intrinsically disordered region of the DEAD-box RNA helicase DDX3X in selective RNA recognition.

DEAD-box RNA 解旋酶 DDX3X 的 N 端固有无序区在选择性 RNA 识别中的调控作用

Bottom-up design of peptide shapes in water using oligomers of N-methyl-l/d-alanine

利用N-甲基-L/D-丙氨酸寡聚体在水中自下而上地设计肽的形状

Structural basis of the residence time of adenosine A(2A) receptor ligands revealed by NMR

核磁共振揭示腺苷A(2A)受体配体停留时间的结构基础

Two-step target recognition for the competitive inhibition activity of an anti-VEGF aptamer

抗 VEGF 适体竞争性抑制活性的两步靶标识别

IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope

癌症中的IMPDH和GTP代谢：机制、调控和转化应用

PI5P4K inhibitors: promising opportunities and challenges

PI5P4K抑制剂：充满机遇与挑战

A high-resolution structural characterization and physicochemical study of how a peptoid binds to an oncoprotein MDM2

肽类化合物与癌蛋白MDM2结合的高分辨率结构表征和理化研究

A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion

高剂量KRP203诱导细胞质空泡形成，并伴有磷脂酰肌醇分离异常和内体扩张。