日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy

对散发性ALS患者诱导多能干细胞衍生的运动神经元进行大规模药物筛选,发现了一种潜在的联合疗法

Bye, Christopher R; Qian, Elizabeth; Lim, Katherine; Daniszewski, Maciej; Garton, Fleur C; Trần-Lê, Bảo C; Liang, Helena H; Lin, Tian; Lock, John G; Crombie, Duncan E; Morgan, Steven; Hu, Yi; Barton, Samantha K; Palmer, Lucy M; Djouma, Elvan; Kodikara, Saritha; Lê Cao, Kim-Anh; Dharmadasa, Thanuja; Henders, Anjali K; Ziser, Laura A; Kiernan, Matthew C; Talbot, Kevin; Needham, Merrilee; Fletcher, Susan; Talman, Paul; Mathers, Susan; Wray, Naomi R; Hewitt, Alex W; Pebay, Alice; Turner, Bradley J

Targeted BDNF upregulation via upstream open reading frame disruption

通过上游开放阅读框破坏靶向上调BDNF

Feng, Ning; Goedert, Thomas; Svrzikapa, Nenad; Yan, Dongnan; Friedrichsen, Hans J; Hanson, Britt; Ljungdahl, Alicia; Dafinca, Ruxandra; Talbot, Kevin; Sanders, Stephan J; Gupta, Dhanu; Wood, Mathew J A; Roberts, Thomas C

Divergence of cortical neurophysiology across different neurodegenerative disorders compared to healthy ageing

不同神经退行性疾病与健康衰老过程中皮层神经生理的差异

Trubshaw, Michael; Kohl, Oliver; Gohil, Chetan; van Es, Mats W J; Quinn, Andrew J; Yoganathan, Katie; Edmond, Evan; Proudfoot, Malcolm; Zokaei, Nahid; Raymont, Vanessa; Pitt, Jemma; Thayanandan, Tony; Thompson, Alexander G; Talbot, Kevin; Hu, Michele T; Perquin, Marlou Nadine; Kocagoncu, Ece; Rowe, James B; Woolrich, Mark W; Nobre, Anna C; Turner, Martin R

Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential.

TDP-43蛋白病中的细胞外囊泡:发病机制和生物标志物潜力

Dellar Elizabeth R, Nikel Lara, Fowler Stephanie, Vahsen Björn F, Dafinca Ruxandra, Feneberg Emily, Talbot Kevin, Turner Martin R, Thompson Alexander G

Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5.

突变亨廷顿蛋白通过解除对非经典聚腺苷酸聚合酶 PAPD5 的抑制来诱导神经元凋亡

Chen Zhefan Stephen, Peng Shaohong Isaac, Leong Lok I, Gall-Duncan Terence, Wong Nathan Siu Jun, Li Tsz Ho, Lin Xiao, Wei Yuming, Koon Alex Chun, Huang Junzhe, Sun Jacquelyne Ka-Li, Turner Clinton, Tippett Lynette, Curtis Maurice A, Faull Richard L M, Kwan Kin Ming, Chow Hei-Man, Ko Ho, Chan Ting-Fung, Talbot Kevin, Pearson Christopher E, Chan Ho Yin Edwin

High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation.

对 C9ORF72 ALS 神经元中的 100,000 个小分子进行高通量筛选,鉴定出剪接体调节剂,这些调节剂可使 G4C2 重复 RNA 动员到核输出和重复相关的非经典翻译

Luteijn Maartje J, Bhaskar Varun, Trojer Dominic, Schürz Melanie, Mahboubi Hicham, Handl Cornelia, Pizzato Nicolas, Pfeifer Martin, Dafinca Ruxandra, Voshol Hans, Giorgetti Elisa, Manneville Carole, Garnier Isabelle P M, Müller Matthias, Zeng Fanning, Buntin Kathrin, Markwalder Roger, Schröder Harald, Weiler Jan, Khar Dora, Schuhmann Tim, Groot-Kormelink Paul J, Keller Caroline Gubser, Farmer Pierre, MacKay Angela, Beibel Martin, Roma Guglielmo, D'Ario Giovanni, Merkl Claudia, Schebesta Michael, Hild Marc, Elwood Fiona, Vahsen Björn F, Ripin Nina, Clery Antoine, Allain Frederic, Labow Mark, Gabriel Daniela, Chao Jeffrey A, Talbot Kevin, Nash Mark, Hunziker Jürg, Meisner-Kober Nicole C

Neurodegenerative disease in C9orf72 repeat expansion carriers: population risk and effect of UNC13A

C9orf72重复扩增携带者的神经退行性疾病:人群风险和UNC13A的影响

Gao, Jiali; Douglas, Andrew G L; Chalitsios, Christos V; Scaber, Jakub; Talbot, Kevin; Turner, Martin R; Thompson, Alexander G

Asymmetry in amyotrophic lateral sclerosis: Clinical, neuroimaging and histological observations

肌萎缩侧索硬化症的不对称性:临床、神经影像学和组织学观察

Yoganathan, Katie; Dharmadasa, Thanuja; Northall, Alicia; Talbot, Kevin; Thompson, Alexander G; Turner, Martin R

Elevated Cerebrospinal Fluid Ubiquitin Carboxyl-Terminal Hydrolase Isozyme L1 in Asymptomatic C9orf72 Hexanucleotide Repeat Expansion Carriers

无症状C9orf72六核苷酸重复序列扩增携带者脑脊液中泛素羧基末端水解酶同工酶L1水平升高

Dellar, Elizabeth R; Vendrell, Iolanda; Amein, Benazir; Lester, David G; Edmond, Evan C; Yoganathan, Katie; Dharmadasa, Thanuja; Sogorb-Esteve, Aitana; Fischer, Roman; Talbot, Kevin; Rohrer, Jonathan D; Turner, Martin R; Thompson, Alexander G

Progression and life expectancy in primary lateral sclerosis

原发性侧索硬化症的进展和预期寿命

Lester, David G; Thompson, Alexander G; Talbot, Kevin; Turner, Martin R