日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Discovery and Phase 1 study of a novel monoclonal antibody against human IL-1β for the treatment of IL-1β-mediated diseases

针对人IL-1β的新型单克隆抗体的发现和I期研究，用于治疗IL-1β介导的疾病

期刊:Clinical and Experimental Immunology
影响因子:3.8
doi:10.1093/cei/uxaf009
Cho, Minseon; Tam, Susan H; Shi, Lihua; Fung, Isa; Tornetta, Mark; Canziani, Gabriela A; Fung, Man-Cheong; Chiu, Mark L; Han, Chao; Zhang, Di
单克隆抗体
IL-1β
发表日期：2025
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A novel monoclonal antibody against human thymic stromal lymphopoietin for the treatment of TSLP-mediated diseases

一种新型抗人胸腺基质淋巴细胞生成素单克隆抗体，用于治疗TSLP介导的疾病

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2024.1442588
Shi, Lihua; Yu, Mingcan; Jin, Ying; Chen, Peng; Mu, Guangmao; Tam, Susan H; Cho, Minseon; Tornetta, Mark; Han, Chao; Fung, Man-Cheong; Chiu, Mark L; Zhang, Di
单克隆抗体
细胞生物学
TSLP
发表日期：2024
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Toward a Combinatorial Approach for the Prediction of IgG Half-Life and Clearance.

预测 IgG 半衰期和清除率的组合方法

期刊:Drug Metabolism and Disposition
影响因子:4
doi:10.1124/dmd.118.081893
Goulet Dennis R, Watson Michael J, Tam Susan H, Zwolak Adam, Chiu Mark L, Atkins William M, Nath Abhinav
信号转导
IgG
发表日期：2018
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Functional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality.

人类 IgG1 和 IgG4 Fc 变体的功能、生物物理和结构表征及其免疫功能的丧失

期刊:Antibodies
影响因子:2.7
doi:10.3390/antib6030012
Tam Susan H, McCarthy Stephen G, Armstrong Anthony A, Somani Sandeep, Wu Sheng-Jiun, Liu Xuesong, Gervais Alexis, Ernst Robin, Saro Dorina, Decker Rose, Luo Jinquan, Gilliland Gary L, Chiu Mark L, Scallon Bernard J
信号转导
Human
IGG1
IgG
IgG4
发表日期：2017
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Human and non-human primate intestinal FcRn expression and immunoglobulin G transcytosis

人类和非人灵长类动物肠道FcRn表达和免疫球蛋白G胞吞作用

期刊:Pharmaceutical Research
影响因子:4.3
doi:10.1007/s11095-013-1212-3
Hornby, Pamela J; Cooper, Philip R; Kliwinski, Connie; Ragwan, Edwin; Mabus, John R; Harman, Benjamin; Thompson, Suzanne; Kauffman, Amanda L; Yan, Zhengyin; Tam, Susan H; Dorai, Haimanti; Powers, Gordon D; Giles-Komar, Jill
FcRn
Human
免疫/内分泌
发表日期：2014
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Correlations between pharmacokinetics of IgG antibodies in primates vs. FcRn-transgenic mice reveal a rodent model with predictive capabilities

灵长类动物与FcRn转基因小鼠体内IgG抗体药代动力学的相关性分析揭示了一种具有预测能力的啮齿动物模型

期刊:MAbs
影响因子:7.3
doi:10.4161/mabs.23836
Tam, Susan H; McCarthy, Stephen G; Brosnan, Kerry; Goldberg, Kenneth M; Scallon, Bernard J
IgG
FcRn
发表日期：2013
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Engineering host cell lines to reduce terminal sialylation of secreted antibodies

通过基因工程改造宿主细胞系，以减少分泌抗体的末端唾液酸化。

期刊:MAbs
影响因子:7.3
doi:10.4161/mabs.2.5.13078
Naso, Michael F; Tam, Susan H; Scallon, Bernard J; Raju, T Shantha
细胞生物学
发表日期：2010
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Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

肿瘤相关蛋白酶和微生物蛋白酶通过在铰链区附近的一次切割，破坏宿主IgG效应功能。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.0904174106
Brezski, Randall J; Vafa, Omid; Petrone, Diane; Tam, Susan H; Powers, Gordon; Ryan, Mary H; Luongo, Jennifer L; Oberholtzer, Allison; Knight, David M; Jordan, Robert E
微生物学
IgG
肿瘤
肿瘤免疫
发表日期：2009
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