Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair.
人类 MUTYH 的结构和癌症相关变体的功能分析揭示了其 [4Fe-4S] 簇辅因子和 DNA 修复所需的活性位点之间的变构网络
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-58361-w
Trasviña-Arenas Carlos H, Dissanayake Upeksha C, Tamayo Nikole, Hashemian Mohammad, Lin Wen-Jen, Demir Merve, Hoyos-Gonzalez Nallely, Fisher Andrew J, Cisneros G Andrés, Horvath Martin P, David Sheila S
