日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Reduced dengue virus pre-membrane protein-HMGB1 interaction activates host cell transcription to attenuate infection

登革病毒前膜蛋白与HMGB1相互作用的减弱会激活宿主细胞转录，从而减轻感染。

期刊:NPJ Vaccines
影响因子:6.5
doi:10.1038/s41541-026-01401-3
Siriphanitchakorn, Tanamas; Ooi, Justin S G; Ng, Wy Ching; Tan, Hwee Cheng; Zhang, Summer L; Ng, Dorothy H L; Yap, Xin; Yee, Jia Xin; Zheng, Qiao; Tan, Yi Ting; Ong, Eugenia Z; Chan, Kuan Rong; Choy, Milly M; Ooi, Eng Eong
炎症/感染
HMGB1
细胞生物学
微生物学
发表日期：2026
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Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans

在人体内，疫苗诱导的T细胞反应无需中和抗体即可控制正黄病毒的攻击感染。

期刊:Nature Microbiology
影响因子:19.4
doi:10.1038/s41564-024-01903-7
Kalimuddin, Shirin; Tham, Christine Y L; Chan, Yvonne F Z; Hang, Shou Kit; Kunasegaran, Kamini; Chia, Adeline; Chan, Candice Y Y; Ng, Dorothy H L; Sim, Jean X Y; Tan, Hwee-Cheng; Syenina, Ayesa; Ngoh, An Qi; Hamis, Noor Zayanah; Chew, Valerie; Leong, Yan Shan; Yee, Jia Xin; Low, Jenny G; Chan, Kuan Rong; Ong, Eugenia Z; Bertoletti, Antonio; Ooi, Eng Eong
T细胞
炎症/感染
微生物学
T细胞
细胞生物学
免疫/内分泌
发表日期：2025
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Comparison of human cerebral organoids infected with wild-type Zika versus attenuated DN-2 virus strains uncovers differences in host immune responses.

比较感染野生型寨卡病毒和减毒DN-2病毒株的人类脑类器官，揭示了宿主免疫反应的差异。

期刊:Cell Communication and Signaling
影响因子:8.9
doi:10.1186/s12964-025-02588-z
Choo Yun Ying, Tan Tuan Zea, Zhang Summer Lixin, Tan Hwee Cheng, Ooi Eng Eong, Chua John Jia En
Human
免疫/内分泌
3D/类器官
发表日期：2025
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A natural human cell-adapted dengue type 3 virus strain

一种天然适应人类细胞的登革热3型病毒株

期刊:Microbiology Spectrum
影响因子:3.8
doi:10.1128/spectrum.00701-24
Ng, Wy Ching; Lin, Lowell; Siriphanitchakorn, Tanamas; Jiang, Margaret Ke Xin; Tan, Hwee Cheng; Ooi, Eng Eong
微生物学
细胞生物学
登革热
发表日期：2024
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A phase I/II randomized, double-blinded, placebo-controlled trial of a self-amplifying Covid-19 mRNA vaccine

一项针对自扩增型新冠病毒mRNA疫苗的I/II期随机、双盲、安慰剂对照试验

期刊:NPJ Vaccines
影响因子:6.5
doi:10.1038/s41541-022-00590-x
Low, Jenny G; de Alwis, Ruklanthi; Chen, Shiwei; Kalimuddin, Shirin; Leong, Yan Shan; Mah, Tania Ken Lin; Yuen, Natalene; Tan, Hwee Cheng; Zhang, Summer L; Sim, Jean X Y; Chan, Yvonne F Z; Syenina, Ayesa; Yee, Jia Xin; Ong, Eugenia Z; Sekulovich, Rose; Sullivan, Brian B; Lindert, Kelly; Sullivan, Sean M; Chivukula, Pad; Hughes, Steven G; Ooi, Eng Eong
微生物学
新冠
发表日期：2022
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A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice

单剂基于自转录和复制RNA的SARS-CoV-2疫苗可在小鼠体内产生保护性适应性免疫。

期刊:Molecular Therapy
影响因子:12
doi:10.1016/j.ymthe.2021.04.001
de Alwis, Ruklanthi; Gan, Esther S; Chen, Shiwei; Leong, Yan Shan; Tan, Hwee Cheng; Zhang, Summer L; Yau, Clement; Low, Jenny G H; Kalimuddin, Shirin; Matsuda, Daiki; Allen, Elizabeth C; Hartman, Paula; Park, Kyoung-Joo Jenny; Alayyoubi, Maher; Bhaskaran, Hari; Dukanovic, Adrian; Bao, Yanjie; Clemente, Brenda; Vega, Jerel; Roberts, Scott; Gonzalez, Jose A; Sablad, Marciano; Yelin, Rodrigo; Taylor, Wendy; Tachikawa, Kiyoshi; Parker, Suezanne; Karmali, Priya; Davis, Jared; Sullivan, Brian M; Sullivan, Sean M; Hughes, Steve G; Chivukula, Pad; Ooi, Eng Eong
SARS-CoV-2
免疫/内分泌
发表日期：2021
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Live vaccine infection burden elicits adaptive humoral and cellular immunity required to prevent Zika virus infection

活疫苗感染负荷可诱导产生适应性体液免疫和细胞免疫，从而预防寨卡病毒感染。

期刊:EBioMedicine
影响因子:10.8
doi:10.1016/j.ebiom.2020.103028
Yau, Clement; Gan, Esther Shuyi; Kwek, Swee Sen; Tan, Hwee Cheng; Ong, Eugenia Z; Hamis, Noor Zayanah; Rivino, Laura; Chan, Kuan Rong; Watanabe, Satoru; Vasudevan, Subhash G; Ooi, Eng Eong
炎症/感染
细胞生物学
免疫/内分泌
微生物学
发表日期：2020
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Antibody-Dependent Dengue Virus Entry Modulates Cell Intrinsic Responses for Enhanced Infection

抗体依赖性登革病毒入侵调节细胞内在反应以增强感染

期刊:mSphere
影响因子:3.1
doi:10.1128/mSphere.00528-19
Chan, Candice Y Y; Low, John Zhong Heng; Gan, Esther Shuyi; Ong, Eugenia Ziying; Zhang, Summer Li-Xin; Tan, Hwee Cheng; Chai, Xiaoran; Ghosh, Sujoy; Ooi, Eng Eong; Chan, Kuan Rong
炎症/感染
细胞生物学
微生物学
发表日期：2019
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Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope

通过靶向突变受限的四级表位来中和寨卡病毒的单克隆抗体的合理设计与表征

期刊:Cell Host & Microbe
影响因子:18.7
doi:10.1016/j.chom.2018.04.004
Tharakaraman, Kannan; Watanabe, Satoru; Chan, Kuan Rong; Huan, Jia; Subramanian, Vidya; Chionh, Yok Hian; Raguram, Aditya; Quinlan, Devin; McBee, Megan; Ong, Eugenia Z; Gan, Esther S; Tan, Hwee Cheng; Tyagi, Anu; Bhushan, Shashi; Lescar, Julien; Vasudevan, Subhash G; Ooi, Eng Eong; Sasisekharan, Ram
单克隆抗体
微生物学
发表日期：2018
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Cross-Reactivity and Anti-viral Function of Dengue Capsid and NS3-Specific Memory T Cells Toward Zika Virus

登革热衣壳蛋白和NS3特异性记忆T细胞对寨卡病毒的交叉反应性和抗病毒功能

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2018.02225
Lim, Mei Qiu; Kumaran, Emmanuelle A P; Tan, Hwee Cheng; Lye, David C; Leo, Yee Sin; Ooi, Eng Eong; MacAry, Paul A; Bertoletti, Antonio; Rivino, Laura
T细胞
微生物学
T细胞
细胞生物学
登革热
免疫/内分泌
发表日期：2018
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