Hsp90Â C-terminal domain inhibition enhances ferroptosis by disrupting GPX4-VDAC1 interaction to increase HMOX1 release from oligomerized VDAC1 channels.
Hsp90 C 端结构域抑制通过破坏 GPX4-VDAC1 相互作用来增强铁死亡，从而增加 HMOX1 从寡聚化的 VDAC1 通道中的释放
期刊:Redox Biology
影响因子:11.9
doi:10.1016/j.redox.2025.103672
Li Jieyou, Wu Guibing, Su Hairou, Liang Manfeng, Cen Shengpei, Liao Yandan, Zhou Xiangjun, Xie Guantai, Deng Zihao, Tan Wenchong, Li Yan, Xiao Wang, Liu Lixia, Zhang Jinxin, Zheng Zhenming, Deng Yaotang, Huang Yaling, Shi Xiongjie, Liu Yilin, Zhang Guowei, Chen Xuemei
