Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity
发现4-哌嗪异喹啉衍生物作为强效且可透过血脑屏障的Tau蛋白朊病毒抑制剂,并具有CDK8活性
期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.9b00480
Grandjean, Jean-Marc M; Jiu, Alexander Y; West, John W; Aoyagi, Atsushi; Droege, Daniel G; Elepano, Manuel; Hirasawa, Makoto; Hirouchi, Masakazu; Murakami, Ryo; Lee, Joanne; Sasaki, Koji; Hirano, Shimpei; Ohyama, Takao; Tang, Benjamin C; Vaz, Roy J; Inoue, Masahiro; Olson, Steven H; Prusiner, Stanley B; Conrad, Jay; Paras, Nick A