Tang Chuanxi相关文献与解析，生知库 | 链接生命科学的每一步

Lysophosphatidylcholine promoting Î±-Synuclein aggregation in Parkinson's disease: disrupting GCase glycosylation and lysosomal Î±-Synuclein degradation.

溶血磷脂酰胆碱促进帕金森病中α-突触核蛋白的聚集：破坏GCase糖基化和溶酶体α-突触核蛋白的降解

Mu Chunyan, Shao Kaiquan, Su Mingyu, Guo Yurong, Qiu Yuxiang, Sun Ruiao, Sun Sihan, Sun Yaoyu, Liu Chenkai, Wang Wei, Qin Xiaoling, Tang Chuanxi

其它

发表日期：2025

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Enhanced Microglial Engulfment of Dopaminergic Synapses Induces Parkinson's Disease-Related Executive Dysfunction in an Acute LPC Infusion Targeting the mPFC

急性LPC输注靶向mPFC可增强小胶质细胞对多巴胺能突触的吞噬作用，从而诱发帕金森病相关的执行功能障碍。

期刊:Aging Cell

影响因子:7.1

doi:10.1111/acel.70003

Liu, Yehao; Chen, Rui; Mu, Chunyan; Diao, Junjie; Guo, Yurong; Yao, Xiaoyu; Shi, Shijie; Wang, Mengying; Zhang, Zhi; Qin, Xiaoling; Tang, Chuanxi

GDNF attenuates a-synuclein aggregation-induced damage to VTA-NAc dopaminergic transmission and alleviates depression-like behaviors in mice.

GDNF 可减轻 α-突触核蛋白聚集引起的 VTA-NAc 多巴胺能传递损伤，并缓解小鼠的抑郁样行为

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-16556-7

Chen Jing, Ling Zhi, Lv Maokang, Chen Shengzhe, Xu Wei, Shao Lin, Ma Zifan, Wang Chuanxu, Song Yuanjian, Tang Chuanxi

Investigate the differences in executive functions and behavioral baseline indicators of Parkinson's disease model mice based on the five - choice serial reaction time task

基于五选择序列反应时任务，研究帕金森病模型小鼠执行功能和行为基线指标的差异。

期刊:Laboratory Animal Research

影响因子:2.9

doi:10.1186/s42826-025-00262-6

Gu, Heng; Liao, Zihan; Zhou, Zihang; Liu, Zhiyuan; Gu, Mengying; Liang, Xinyu; Pan, Hong; Tang, Chuanxi

Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease

前额叶皮层中的多巴胺在帕金森病患者的执行功能中发挥着多种作用

期刊:Neural Regeneration Research

影响因子:6.7

doi:10.4103/1673-5374.389631

Zhou, Zihang; Yan, Yalong; Gu, Heng; Sun, Ruiao; Liao, Zihan; Xue, Ke; Tang, Chuanxi

Distinct serum GDNF coupling with brain structural and functional changes underlies cognitive status in Parkinson's disease

血清GDNF水平与脑结构和功能改变之间的独特关联是帕金森病患者认知状态的基础。

期刊:CNS Neuroscience & Therapeutics

影响因子:5

doi:10.1111/cns.14461

Tang, Chuanxi; Sun, Ruiao; Xue, Ke; Wang, Mengying; Liang, Sijie; Kambey, Piniel Alphayo; Shi, Mingyu; Wu, Changyu; Chen, Gang; Gao, Dianshuai

Reviving: restoring depression-like behaviour through glial cell-derived neurotrophic factor treatment in the medial prefrontal cortex

复苏：通过内侧前额叶皮质的神经胶质细胞源性神经营养因子治疗恢复抑郁样行为

期刊:Journal of Psychiatry & Neuroscience

影响因子:4.1

doi:10.1503/jpn.230079

Yehao Liu #, Xiaoyu Zhou #, Ke Xue, Ruiao Sun, Yan Tang, Chuanxi Tang

GDNF improves the cognitive ability of PD mice by promoting glycosylation and membrane distribution of DAT

GDNF通过促进DAT的糖基化和膜分布改善PD小鼠的认知能力

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-024-68609-y

Ma Chengcheng, An Panpan, Yan Yalong, Su Mingyu, Xu Wei, Chen Jing, Tang Chuanxi

Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity

金烷型倍半萜四酮化合物是一种具有白细胞介素-17A 抑制活性的新型免疫调节剂

期刊:Acta Pharmaceutica Sinica B

影响因子:14.7

doi:10.1016/j.apsb.2023.03.017

Xin Tang, Chuanxi Wang, Lei Wang, Feifei Ren, Runqiao Kuang, Zhenhua Li, Xue Han, Yiming Chen, Guodong Chen, Xiuqing Wu, Jie Liu, Hengwen Yang, Xingzhong Liu, Chen Wang, Hao Gao, Zhinan Yin

High-efficacy serum biomarkers PCSK9 and LCAT predict cognitive impairment in Parkinson's disease

高效血清生物标志物PCSK9和LCAT可预测帕金森病患者的认知障碍

Lysophosphatidylcholine promoting Î±-Synuclein aggregation in Parkinson's disease: disrupting GCase glycosylation and lysosomal Î±-Synuclein degradation.

溶血磷脂酰胆碱促进帕金森病中α-突触核蛋白的聚集：破坏GCase糖基化和溶酶体α-突触核蛋白的降解

Enhanced Microglial Engulfment of Dopaminergic Synapses Induces Parkinson's Disease-Related Executive Dysfunction in an Acute LPC Infusion Targeting the mPFC

急性LPC输注靶向mPFC可增强小胶质细胞对多巴胺能突触的吞噬作用，从而诱发帕金森病相关的执行功能障碍。

GDNF attenuates a-synuclein aggregation-induced damage to VTA-NAc dopaminergic transmission and alleviates depression-like behaviors in mice.

GDNF 可减轻 α-突触核蛋白聚集引起的 VTA-NAc 多巴胺能传递损伤，并缓解小鼠的抑郁样行为

Investigate the differences in executive functions and behavioral baseline indicators of Parkinson's disease model mice based on the five - choice serial reaction time task

基于五选择序列反应时任务，研究帕金森病模型小鼠执行功能和行为基线指标的差异。

Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease

前额叶皮层中的多巴胺在帕金森病患者的执行功能中发挥着多种作用

Distinct serum GDNF coupling with brain structural and functional changes underlies cognitive status in Parkinson's disease

血清GDNF水平与脑结构和功能改变之间的独特关联是帕金森病患者认知状态的基础。

Reviving: restoring depression-like behaviour through glial cell-derived neurotrophic factor treatment in the medial prefrontal cortex

复苏：通过内侧前额叶皮质的神经胶质细胞源性神经营养因子治疗恢复抑郁样行为

GDNF improves the cognitive ability of PD mice by promoting glycosylation and membrane distribution of DAT

GDNF通过促进DAT的糖基化和膜分布改善PD小鼠的认知能力

Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity

金烷型倍半萜四酮化合物是一种具有白细胞介素-17A 抑制活性的新型免疫调节剂