日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single-cell imaging analysis, therapeutic modeling and a Phase Ib trial validate BCL-2 as a target across heterogeneous castration-resistant prostate cancer

单细胞成像分析、治疗模型和 Ib 期试验证实 BCL-2 是异质性去势抵抗性前列腺癌的治疗靶点。

Jamroze, Anmbreen; Liu, Xiaozhuo; Hou, Surui; Jess Li, Wen; Yu, Han; Tracz, Amanda; Jacobi, Justine; Li, Qiuhui; Nastiuk, Kent; Chen, Xin; Huang, Jiaoti; Lin, Kevin; Liu, Mingyu; Cai, Changmeng; Lu, Yue; Puzanov, Igor; Kirk, Jason S; Chatta, Gurkamal; Tang, Dean G

Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma.

雄性胚胎后脑中的雄激素活性会引发致命的 PFA 室管膜瘤。

Zhang Jiao, Ong Winnie, Rasnitsyn Alexandra, Gonzalez Ricardo Daniel, Lopez Gutierrez Rodrigo, Balin Polina, Saadeldin Amr, Wu Xiaochong, Vladoiu Maria C, Santa-Maria Lopez Vicente, Gonzalez-Salinas Fernando, Yadav Navneesh, Mohanakrishnan Dinesh, Boosi Narayana Rao Kannan, Mooli Raja Gopal Reddy, Najem Hinda, Pacheco Sebastian, Kharas Kaitlin, Richman Cory, Przelicki David, Wang Evan Y, Su Haipeng, Curry Rachel Naomi, Yang Runze, Kameda-Smith Michelle Masayo, Livingston Bryn, Scott David, Luo Zaili, Xia Mingyang, Abeysundara Namal, Erickson Anders W, Mankahla Ncedile, Hu Lucas ZhongMing, Pan Chu, Suarez Raul, Huang Ning, Wu Yihao, Wang Hao, Douglas Tajana, Pallota Jonelle, Hébert Steven, Ng Karen, Mantione Krystin, Whetstone Heather, Maan Hassaan, Lakkis Hussein, Lee Juyeun, Ramakrishnan Sadeesh K, Pei Yanxin, Tang Yujie, Lin Frank Y, Aldave Guillermo, Gallo Marco, Friedlander Robert M, Notta Faiyaz, Donovan Laura K, Chintagumpala Murali, Wang Bo, Li Yun, De Carvalho Daniel D, Zhang Zhaolei, Mao Ying, Hua Wei, Eberhart Charles, Lucas Calixto-Hope G, Venneti Sriram, Sorensen Poul H, Delaidelli Alberto, Li Hao, Zhou Wenhao, Kirk Jason, Tang Dean G, Jiang Tao, Liu Hailong, Lathia Justin D, Suzuki Hiromichi, Rich Jeremy N, Stein Lincoln D, Jabado Nada, Ramaswamy Vijay, Lu Q Richard, Heimberger Amy B, Daniels Craig, Michealraj Kulandaimanuvel Antony, Kleinman Claudia L, Taylor Michael D

The temporal dynamics of the immune response to neoadjuvant androgen deprivation therapy suggests a window-of-opportunity for checkpoint inhibitor therapy in prostate cancer

新辅助雄激素剥夺疗法后免疫反应的时间动态变化提示前列腺癌存在免疫检查点抑制剂治疗的“机会窗口”。

Jamroze, Anmbreen; Zhang, Renyuan; Ahuja, Kriti; Deng, Lei; Jatwani, Karan; Nguyen, Uyen; Farmer, Bailey; James, Gaybrielle; Mastri, Michalis; Eng, Kevin H; Xu, Bo; Saenger, Yvonne M; Yang, Yuanquan; Krolewski, John J; Tang, Dean G; Chatta, Gurkamal; Nastiuk, Kent L

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition

利用肿瘤微环境:通过调控上皮-间质转化实现靶向癌症治疗

Glaviano, Antonino; Lau, Hannah Si-Hui; Carter, Lukas M; Lee, E Hui Clarissa; Lam, Hiu Yan; Okina, Elena; Tan, Donavan Jia Jie; Tan, Wency; Ang, Hui Li; Carbone, Daniela; Yee, Michelle Yi-Hui; Shanmugam, Muthu K; Huang, Xiao Zi; Sethi, Gautam; Tan, Tuan Zea; Lim, Lina H K; Huang, Ruby Yun-Ju; Ungefroren, Hendrik; Giovannetti, Elisa; Tang, Dean G; Bruno, Tullia C; Luo, Peng; Andersen, Mads Hald; Qian, Bin-Zhi; Ishihara, Jun; Radisky, Derek C; Elias, Salem; Yadav, Saurabh; Kim, Minah; Robert, Caroline; Diana, Patrizia; Schalper, Kurt A; Shi, Tao; Merghoub, Taha; Krebs, Simone; Kusumbe, Anjali P; Davids, Matthew S; Brown, Jennifer R; Kumar, Alan Prem

Serotonin sets up neutrophil extracellular traps to promote neuroendocrine prostate cancer metastasis in the liver

血清素通过建立中性粒细胞胞外陷阱促进神经内分泌前列腺癌向肝脏的转移

Tang, Dean G

Elimination of docetaxel-induced senescence attenuates malignant progression in RB1-deficient CRPC

消除多西他赛诱导的衰老可减缓RB1缺陷型去势抵抗性前列腺癌的恶性进展。

Su, Huilan; Huang, Liqun; Xia, Wenwen; Tang, Dean G; Zhou, Jianjun; Yang, Guosheng

Phase Ib study of enzalutamide with venetoclax in patients with metastatic castration-resistant prostate cancer

恩扎卢胺联合维奈托克治疗转移性去势抵抗性前列腺癌患者的Ib期研究

Perimbeti, Stuthi; Jamroze, Anmbreen; Gopalakrishnan, Dharmesh; Jain, Rohit; Jiang, Changchuan; Holleran, Julianne L; Parise, Robert A; Bies, Robert; Quinn, David; Attwood, Kristopher; Liu, Xiaozhuo; Green, Kelly; Kirk, Jason S; Beumer, Jan H; Tang, Dean G; Chatta, Gurkamal

Loss of ATG5 expression in a subset of human prostate cancers promotes tumor growth through accumulation of p62

在部分人类前列腺癌中,ATG5表达的缺失通过p62的积累促进肿瘤生长。

Wible, Daric J; Li, Wen Jess; Liu, Xiaozhuo; Sebastian, Manu M; Tang, Dean G; Bratton, Shawn B

Increasing Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient Survival

干细胞特性增强会促进前列腺癌的进展、可塑性、治疗耐药性和患者生存率降低。

Liu, Xiaozhuo; Cortes, Eduardo; Ji, Yibing; Zhao, Kathy; Ho, Julian; Liu, Yang Seagle; Davicioni, Elai; Feng, Felix Y; Alumkal, Joshi J; Spratt, Daniel E; Sweeney, Christopher J; Yu, Han; Hu, Qiang; Cheng, Zou; Zhang, Dingxiao; Chatta, Gurkamal; Nastiuk, Kent L; Goodrich, David W; Rycaj, Kiera; Jamroze, Anmbreen; Kirk, Jason S; Puzanov, Igor; Liu, Song; Wang, Jianmin; Tang, Dean G

Cell-resolved high-dimensional imaging analysis, therapeutic modeling, and a Phase Ib clinical study establish BCL-2 as a target across heterogeneous CRPC subtypes

细胞分辨高维成像分析、治疗模型构建以及 Ib 期临床研究证实 BCL-2 是异质性 CRPC 亚型的治疗靶点。

Jamroze, Anmbreen; Liu, Xiaozhuo; Hou, Surui; Li, Wen Jess; Yu, Han; Tracz, Amanda; Li, Qiuhui; Nastiuk, Kent; Chen, Xin; Huang, Jiaoti; Lin, Kevin; Lu, Yue; Puzanov, Igor; Kirk, Jason S; Chatta, Gurkamal; Tang, Dean G