Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype.
磷酸二酯酶 10A 单倍体不足可激活 PI3K/AKT 信号通路，该通路不依赖于 PTEN，从而诱导侵袭性胶质瘤表型
期刊:Genes & Development
影响因子:7.7
doi:10.1101/gad.351350.123
Nuechterlein Nicholas, Shelbourn Allison, Szulzewsky Frank, Arora Sonali, Casad Michelle, Pattwell Siobhan, Merino-Galan Leyre, Sulman Erik, Arowa Sumaita, Alvinez Neriah, Jung Miyeon, Brown Desmond, Tang Kayen, Jackson Sadhana, Stoica Stefan, Chittaboina Prashant, Banasavadi-Siddegowda Yeshavanth K, Wirsching Hans-Georg, Stella Nephi, Shapiro Linda, Paddison Patrick, Patel Anoop P, Gilbert Mark R, Abdullaev Zied, Aldape Kenneth, Pratt Drew, Holland Eric C, Cimino Patrick J
