P-LM421E8, the heparan sulfate chain-conjugated laminin-421-E8 fragment, drives differentiation of human induced pluripotent stem cells into hematopoietic progenitor cells comparable to basic fibroblast growth factor in a chemically defined system
P-LM421E8,即硫酸乙酰肝素链偶联的层粘连蛋白-421-E8片段,在化学成分明确的系统中,能够驱动人诱导多能干细胞分化为造血祖细胞,其效果与碱性成纤维细胞生长因子相当。
期刊:Matrix Biology Plus
影响因子:
doi:10.1016/j.mbplus.2025.100188
Ninomiya, Naoto; Sasaki, Kaoru; Katori, Ryosuke; Shimizu, Yasuhiro; Fujita, Kazumasa; Taniguchi, Yukimasa; Kunieda, Taiko; Tamura, Kouichi; Yamada, Masashi; Sekiguchi, Kiyotoshi; Kimura, Hironobu