Tanner John J相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Serendipitous discovery of an allosteric inhibitor binding groove in the proline biosynthetic enzyme pyrroline-5-carboxylate reductase 1

在脯氨酸生物合成酶吡咯啉-5-羧酸还原酶1中意外发现变构抑制剂结合槽

期刊:Biochemical Journal

影响因子:4.3

doi:10.1042/BCJ20250278

Meeks, Kaylen R; Mattingly, Caitlin J; Nix, Jay C; Chuk, Oleksii; Protopopov, Mykola V; Tarkhanova, Olga O; Tanner, John J

发表日期：2026

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Visualization of covalent intermediates and conformational states of proline utilization A by X-ray crystallography and molecular dynamics simulations

利用X射线晶体学和分子动力学模拟可视化脯氨酸利用A的共价中间体和构象状态

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2025.110532

Buckley, David P; Becker, Donald F; Tanner, John J

发表日期：2025

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Biochemical, structural, and cellular characterization of S-but-3-yn-2-ylglycine as a mechanism-based covalent inactivator of the flavoenzyme proline dehydrogenase

对S-丁-3-炔-2-基甘氨酸作为黄素酶脯氨酸脱氢酶的机制性共价失活剂的生化、结构和细胞表征

期刊:Archives of Biochemistry and Biophysics

doi:10.1016/j.abb.2025.110319

Meeks, Kaylen R; Ji, Juan; Scott, Gary K; Campbell, Ashley C; Nix, Jay C; Tadeo, Ada; Ellerby, Lisa M; Benz, Christopher C; Tanner, John J

细胞生物学

发表日期：2025

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Biochemical, structural, and computational analyses of two new clinically identified missense mutations of ALDH7A1

对ALDH7A1基因中两个新发现的临床错义突变进行生化、结构和计算分析

期刊:Chemico-Biological Interactions

影响因子:5.4

doi:10.1016/j.cbi.2024.110993

Korasick, David A; Buckley, David P; Palpacelli, Alessandra; Cursio, Ida; Cesaroni, Elisabetta; Cheng, Jianlin; Tanner, John J

发表日期：2024

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Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography

基于分子对接引导的X射线晶体学方法鉴定的PYCR1新型片段抑制剂

期刊:Journal of Chemical Information and Modeling

影响因子:5.3

doi:10.1021/acs.jcim.3c01879

Meeks, Kaylen R; Ji, Juan; Protopopov, Mykola V; Tarkhanova, Olga O; Moroz, Yurii S; Tanner, John J

发表日期：2024

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Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1)

利用基于知识库的小分子化合物库筛选脯氨酸生物合成酶 1-吡咯啉-5-羧酸酯 1 (PYCR1)

期刊:Protein Science

影响因子:5.2

doi:10.1002/pro.5072

Meeks, Kaylen R; Bogner, Alexandra N; Tanner, John J

发表日期：2024

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Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase

双功能脯氨酸分解代谢酶的晶体学片段筛选揭示了脯氨酸脱氢酶和L-谷氨酸-γ-半醛脱氢酶的新抑制剂模板

期刊:Molecules

影响因子:4.6

doi:10.3390/molecules29225408

Meeks, Kaylen R; Bogner, Alexandra N; Nix, Jay C; Tanner, John J

发表日期：2024

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Therapeutic targeting of HYPDH/PRODH2 with N-propargylglycine offers a Hyperoxaluria treatment opportunity

利用N-丙炔甘氨酸靶向HYPDH/PRODH2进行治疗，为高草酸尿症的治疗提供了一种新的契机。

期刊:Biochimica et Biophysica Acta-Molecular Basis of Disease

影响因子:4.2

doi:10.1016/j.bbadis.2023.166848

Bons, Joanna; Tadeo, Ada; Scott, Gary K; Teramayi, Fadzai; Tanner, John J; Schilling, Birgit; Benz, Christopher C; Ellerby, Lisa M

发表日期：2024

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Noncovalent Inhibition and Covalent Inactivation of Proline Dehydrogenase by Analogs of N-Propargylglycine

N-丙炔甘氨酸类似物对脯氨酸脱氢酶的非共价抑制和共价失活

期刊:Biochemistry

doi:10.1021/acs.biochem.4c00429

Tanner, John J; Ji, Juan; Bogner, Alexandra N; Scott, Gary K; Patel, Sagar M; Seravalli, Javier; Gates, Kent S; Benz, Christopher C; Becker, Donald F

发表日期：2024

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Functional Impact of a Cancer-Related Variant in Human Δ(1)-Pyrroline-5-Carboxylate Reductase 1

人类Δ(1)-吡咯啉-5-羧酸还原酶1中癌症相关变异的功能影响

期刊:ACS Omega

影响因子:4.3

doi:10.1021/acsomega.2c07788

Daudu, Oseeyi I; Meeks, Kaylen R; Zhang, Lu; Seravalli, Javier; Tanner, John J; Becker, Donald F

发表日期：2023

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