日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile

在siRNA种子区对siRNA骨架进行单烷基膦酸酯修饰可增强其特异性和治疗效果。

Nikan, Mehran; Li, Qingfeng; Tanowitz, Michael; Li, Hongda; Damle, Sagar; Annoual, Marie; Galindo-Murillo, Rodrigo; Low, Audrey; Klein, Stephanie; Quirk, Clare; Vasquez, Guillermo; Wan, W Brad; Watt, Andrew T; Migawa, Michael T; Swayze, Eric E; Prakash, Thazha P

Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles

与转铁蛋白受体1结合的双环肽偶联可增强ASO和siRNA在骨骼肌和心肌中的效力。

Østergaard, Michael E; Carrer, Michele; Anderson, Brooke A; Afetian, Megan; Bakooshli, Mohsen A; Santos, Jinro A; Klein, Stephanie K; Capitanio, Juliana; Freestone, Graeme C; Tanowitz, Michael; Galindo-Murillo, Rodrigo; Gaus, Hans J; Dwyer, Chrissa A; Jackson, Michaela; Jafar-Nejad, Paymaan; Rigo, Frank; Seth, Punit P; Gaynor, Katherine U; Stanway, Steven J; Urbonas, Liudvikas; St Denis, Megan A; Pellegrino, Simone; Bezerra, Gustavo A; Rigby, Michael; Gowans, Ellen; Van Rietschoten, Katerine; Beswick, Paul; Chen, Liuhong; Skynner, Michael J; Swayze, Eric E

High-resolution visualization and quantification of nucleic acid-based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS)

使用纳米级二次离子质谱 (NanoSIMS) 对细胞和组织中的核酸治疗剂进行高分辨率可视化和量化

Cuiwen He, Michael T Migawa, Kai Chen, Thomas A Weston, Michael Tanowitz, Wenxin Song, Paul Guagliardo, K Swaminathan Iyer, C Frank Bennett, Loren G Fong, Punit P Seth, Stephen G Young, Haibo Jiang

Trypanosoma cruzi Promotes Transcriptomic Remodeling of the JAK/STAT Signaling and Cell Cycle Pathways in Myoblasts

克氏锥虫促进成肌细胞中JAK/STAT信号通路和细胞周期通路的转录组重塑

Nisimura, Lindice M; Coelho, Laura L; de Melo, Tatiana G; Vieira, Paloma de Carvalho; Victorino, Pedro H; Garzoni, Luciana R; Spray, David C; Iacobas, Dumitru A; Iacobas, Sanda; Tanowitz, Herbert B; Adesse, Daniel

Chagas Disease in the New York City Metropolitan Area

纽约市大都会区的恰加斯病

Zheng, Crystal; Quintero, Orlando; Revere, Elizabeth K; Oey, Michael B; Espinoza, Fabiola; Puius, Yoram A; Ramirez-Baron, Diana; Salama, Carlos R; Hidalgo, Luis F; Machado, Fabiana S; Saeed, Omar; Shin, Jooyoung; Patel, Snehal R; Coyle, Christina M; Tanowitz, Herbert B

The role of fat on cardiomyopathy outcome in mouse models of chronic Trypanosoma cruzi infection

脂肪在慢性克氏锥虫感染小鼠模型心肌病结局中的作用

Zaki, Paul; Domingues, Elisa Lbc; Amjad, Farhad M; Narde, Maiara B; Gonçalves, Karolina R; Viana, Mirelle L; de Paula, Heberth; de Lima, Wanderson G; Huang, Huan; Bahia, Maria T; Sherer, Philipp E; Dos Santos, Fabiane M; Weiss, Louis M; Tanowitz, Herbert B

Selective tissue targeting of synthetic nucleic acid drugs

合成核酸药物的选择性组织靶向

Seth, Punit P; Tanowitz, Michael; Bennett, C Frank

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

通过位点特异性地用烷基膦酸酯键取代硫代磷酸酯键,可以调节间隙型反义寡核苷酸(ASO)与细胞蛋白的相互作用,从而增强其治疗效果。

Migawa, Michael T; Shen, Wen; Wan, W Brad; Vasquez, Guillermo; Oestergaard, Michael E; Low, Audrey; De Hoyos, Cheryl L; Gupta, Ruchi; Murray, Susan; Tanowitz, Michael; Bell, Melanie; Nichols, Joshua G; Gaus, Hans; Liang, Xue-Hai; Swayze, Eric E; Crooke, Stanley T; Seth, Punit P

Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates

疏水基团的偶联增强了反义寡核苷酸在啮齿动物和非人灵长类动物肌肉中的效力。

Østergaard, Michael E; Jackson, Michaela; Low, Audrey; E Chappell, Alfred; G Lee, Richard; Peralta, Rachel Q; Yu, Jinghua; Kinberger, Garth A; Dan, Amy; Carty, Rick; Tanowitz, Michael; Anderson, Patrick; Kim, Tae-Won; Fradkin, Linda; Mullick, Adam E; Murray, Sue; Rigo, Frank; Prakash, Thazha P; Bennett, C Frank; Swayze, Eric E; Gaus, Hans J; Seth, Punit P

Endothelins in inflammatory neurological diseases

炎症性神经系统疾病中的内皮细胞

D'Orléans-Juste, Pedro; Akide Ndunge, Oscar B; Desbiens, Louisane; Tanowitz, Herbert B; Desruisseaux, Mahalia S