Tanzi相关文献与解析，生知库 | 链接生命科学的每一步

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition.

性别特异性的 APOE4 依赖性先天免疫调节脑膜淋巴管、脑脂质、神经炎症和认知。

doi:10.1016/j.neuron.2026.02.030

Delivanoglou Nickoleta, Todd Kennedi T, Almeida Francisco, Rego Shanon, Changavi Amogh, Spajer Myriam, Ayuso Virginia Estades, Pinho-Correia Liliana M, Sanchez Guadalupe, das Neves Sofia P, Barber Megan J, Schrader Racquelle, Sacilotto Patricia, Martens Yuka A, Heckman Michael G, Bu Guojun, Tanzi Rudolph E, Thomas Jean-Leon, Fryer John D, Oliveira Tiago Gil, Shekhar Karthik, Da Mesquita Sandro

神经炎症

神经科学

APOE

Immunology/Inflammation

炎症

发表日期：2026

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RIN3 mutations impairing binding of the Alzheimer's disease-associated protein BIN1 lead to RAB5 hyperactivation and endosomal pathology.

RIN3 突变会损害阿尔茨海默病相关蛋白 BIN1 的结合，导致 RAB5 过度激活和内体病变。

期刊:Science Advances

影响因子:12.5

doi:10.1126/sciadv.adx2127

Maaser-Hecker Anna K, Zellmer Jacob C, Kim Michelle, Bakiasi Grisilda, Maiti Amit K, Curtat Matea P C, Choi Se Hoon, Prokopenko Dmitry, Tanzi Rudolph E, Bhattacharyya Raja

Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease-associated genes in the Hispanic population

通过预测主成分匹配异质性队列，揭示了西班牙裔人群中两个新的阿尔茨海默病相关基因

期刊:Alzheimers & Dementia

影响因子:11.1

doi:10.1002/alz.71189

Willett, Julian Daniel Sunday; Waqas, Mohamad; Naumenko, Serhiy; Mullin, Kristina; Hecker, Julian; Bertram, Lars; Lange, Christoph; Vlachos, Ioannis; Hide, Winston; Tanzi, Rudolph E; Prokopenko, Dmitry

阿尔茨海默症

发表日期：2026

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Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's disease.

细胞内蛋白GBF1与阿尔茨海默病中的淀粉样蛋白病理有显著关联。

期刊:Alzheimers & Dementia

影响因子:11.1

doi:10.1002/alz.71271

Miller Sean J, Prokopenko Dmitry, Bai Ping, Mondal Prasenjit, Scott Abigael, Zhang Wei, Gomm Ashley, Zhang Siyi, Child Daniel D, Shen Nolan, Ward Joseph, Schulte Scott, Lei Dan, Hafler Brian P, Wang Changning, Tanzi Rudolph E, Zhang Can

Highly sensitive chemiluminescence imaging of misfolded proteins in neurodegenerative models.

利用高灵敏度化学发光成像技术对神经退行性疾病模型中的错误折叠蛋白进行成像。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2513311123

Zhu Biyue, Liu Zhenhua, Van Richard, Wang Huizhe, Kuang Shi, Jia Yuntao, Leon Erick Calderon, Yang Fan, Zhang Jing, Yang Jun, Hong Howard, Lobo Fleur, Yu Astra, Wang Johnson, Tanzi Rudolph E, Zhang Can, Mao Xiaobo, Shao Yihan, Ran Chongzhao

神经科学

发表日期：2026

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Linking sleep microstructure, blood markers of inflammation and metabolism, and cognition: mediation analysis in the osteoporotic fractures in men study

睡眠微结构、炎症和代谢血液标志物以及认知之间的联系：男性骨质疏松性骨折研究中的中介分析

期刊:Geroscience

影响因子:5.4

doi:10.1007/s11357-025-01730-6

Suen, Claire; Ma, Julia; Lin, Xihong; Thomas, Robert J; Westover, M Brandon; Stone, Katie; Yaffe, Kristine; Ensrud, Kristine E; Redline, Susan; Tanzi, Rudolph E; Sun, Haoqi; Zhang, Can

Alzheimer's disease-linked ACE variants increase ACE1 catalytic activity and production of angiotensin II.

与阿尔茨海默病相关的 ACE 变体增加 ACE1 催化活性和血管紧张素 II 的产生。

期刊:Journal of Biological Chemistry

影响因子:3.9

doi:10.1016/j.jbc.2026.111171

Salvo Miranda A, Cuddy Leah K, Prokopenko Dmitry, Watkins Elyse, Tanzi Rudolph E, Vassar Robert

Left Atrial Strain Correlation with Functional Capacity and Additional Prognostic Value of Speckle Tracking in Cardiac Amyloidosis: A Prospective, Single-Center Study

左心房应变与功能能力的相关性以及斑点追踪在心脏淀粉样变性中的额外预后价值：一项前瞻性单中心研究

期刊:Journal of Clinical Medicine

影响因子:2.9

doi:10.3390/jcm15041337

Pastore, Maria Concetta; Focardi, Marta; Marrese, Federica; Giacomin, Elisa; Ragazzoni, Gian Luca; Susini, Francesca; Gozzetti, Alessandro; Mandoli, Giulia Elena; Cavigli, Luna; Placuzzi, Elena; Spaccaterra, Laura; Rosi, Sara; Tanzi, Lorenzo; D'Ascenzi, Flavio; Valente, Serafina; Cameli, Matteo

发表日期：2026

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Immune dysfunction in Alzheimer disease

阿尔茨海默病中的免疫功能障碍

Molecular recognition of thyroglobulin by sortilin.

分选蛋白对甲状腺球蛋白的分子识别。

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition.

性别特异性的 APOE4 依赖性先天免疫调节脑膜淋巴管、脑脂质、神经炎症和认知。

RIN3 mutations impairing binding of the Alzheimer's disease-associated protein BIN1 lead to RAB5 hyperactivation and endosomal pathology.

RIN3 突变会损害阿尔茨海默病相关蛋白 BIN1 的结合，导致 RAB5 过度激活和内体病变。

Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease-associated genes in the Hispanic population

通过预测主成分匹配异质性队列，揭示了西班牙裔人群中两个新的阿尔茨海默病相关基因

Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's disease.

细胞内蛋白GBF1与阿尔茨海默病中的淀粉样蛋白病理有显著关联。

Highly sensitive chemiluminescence imaging of misfolded proteins in neurodegenerative models.

利用高灵敏度化学发光成像技术对神经退行性疾病模型中的错误折叠蛋白进行成像。

Linking sleep microstructure, blood markers of inflammation and metabolism, and cognition: mediation analysis in the osteoporotic fractures in men study

睡眠微结构、炎症和代谢血液标志物以及认知之间的联系：男性骨质疏松性骨折研究中的中介分析

Alzheimer's disease-linked ACE variants increase ACE1 catalytic activity and production of angiotensin II.

与阿尔茨海默病相关的 ACE 变体增加 ACE1 催化活性和血管紧张素 II 的产生。

Left Atrial Strain Correlation with Functional Capacity and Additional Prognostic Value of Speckle Tracking in Cardiac Amyloidosis: A Prospective, Single-Center Study

左心房应变与功能能力的相关性以及斑点追踪在心脏淀粉样变性中的额外预后价值：一项前瞻性单中心研究