日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8+ T cells

联合使用抗PD-1和抗CTLA-4疗法可产生多波克隆反应,其中包括祖细胞耗竭的CD8+ T细胞。

Kevin Wang ,Paulina Coutifaris ,David Brocks ,Guanning Wang ,Tarek Azar ,Sabrina Solis ,Ajeya Nandi ,Shaneaka Anderson ,Nicholas Han ,Sasikanth Manne ,Evgeny Kiner ,Chirag Sachar ,Minke Lucas ,Sangeeth George ,Patrick K Yan ,Melanie W Kier ,Amy I Laughlin ,Shawn Kothari ,Josephine Giles ,Divij Mathew ,Reem Ghinnagow ,Cecile Alanio ,Ahron Flowers ,Wei Xu ,Daniel J Tenney ,Xiaowei Xu ,Ravi K Amaravadi ,Giorgos C Karakousis ,Lynn M Schuchter ,Marcus Buggert ,Derek Oldridge ,Andy J Minn ,Christian Blank ,Jeffrey S Weber ,Tara C Mitchell ,Michael D Farwell ,Ramin S Herati ,Alexander C Huang

LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity

LAG-3 维持 TOX 表达并调节 CD94/NKG2-Qa-1b 轴,从而控制耗竭 CD8 T 细胞 NK 受体的表达和细胞毒性。

Shin Foong Ngiow ,Sasikanth Manne ,Yinghui Jane Huang ,Tarek Azar ,Zeyu Chen ,Divij Mathew ,Qingzhou Chen ,Omar Khan ,Jennifer E Wu ,Victor Alcalde ,Ahron J Flowers ,Sean McClain ,Amy E Baxter ,Makoto Kurachi ,Junwei Shi ,Alexander C Huang ,Josephine R Giles ,Arlene H Sharpe ,Dario A A Vignali ,E John Wherry