Inducible FAK loss but not FAK inhibition in endothelial cells of PYK2-null mice activates p53 tumor suppressor to prevent tumor growth.
PYK2 基因敲除小鼠内皮细胞中 FAK 的诱导性缺失(而非 FAK 的抑制)可激活 p53 肿瘤抑制因子,从而阻止肿瘤生长
期刊:Molecular Biology of the Cell
影响因子:2.7
doi:10.1091/mbc.E24-12-0562
Chen Xiao Lei, Ojalill Marjaana, Jean Christine, Tancioni Isabelle, Jiang Shulin, Boyer Antonia, Ozmadenci Duygu, Uryu Sean, Tarin David, Schlessinger Joseph, Stupack Dwayne G, Schlaepfer David D