IFN-γ-driven skewing towards Th1 over Th17 differentiation underlies CRS and neutropenia in CAR-T therapy
IFN-γ驱动的Th1细胞分化相对于Th17细胞分化的偏倚是CAR-T疗法中细胞因子释放综合征(CRS)和中性粒细胞减少症的根本原因。
期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI194631
Goala, Payal; Zhang, Yongliang; Beatty, Nolan; Pavy, Allan; McSain, Shannon; Sailer, Cooper; Tariq, Muhammad Junaid; Hamid, Showkat; Cortes Gomez, Eduardo; Wang, Jianmin; Massillon, Duna; Ilecki, Maxwell; Boucher, Justin C; Savid-Frontera, Constanza; Lee, Sae Bom; Kotani, Hiroshi; Stone, Meredith L; Jain, Michael D; Davila, Marco L