日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Mass balance, pharmacokinetics, metabolism, and excretion of radiolabeled acoziborole, a potential novel treatment for human African trypanosomiasis, following single microtracer oral dose to humans

人体单次口服微量示踪剂后，放射性标记的阿可唑硼罗（一种潜在的治疗人类非洲锥虫病的新药）的质量平衡、药代动力学、代谢和排泄情况

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/aac.00580-25
Gillon, Jean-Yves; Simon, François; Sidhu, Sharan; Louis, Mathieu; Launay, Delphine; Wauthier, Valérie; Pelay-Gimeno, Marta; Andel, Lotte van; Loyau, Sabrina; Rembry, Sandra; Weinling, Estelle; Tarral, Antoine
代谢
发表日期：2025
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The STROGHAT study protocol: An intervention study to evaluate safety, effectiveness and feasibility of treating gambiense HAT seropositive subjects with acoziborole

STROGHAT 研究方案：一项评估使用阿可唑硼罗治疗冈比亚锥虫病血清阳性受试者的安全性、有效性和可行性的干预研究

期刊:Open Research Europe
影响因子:
doi:10.12688/openreseurope.19077.1
Nicco, Elena; Lejon, Veerle; Mwamba Miaka, Erick; Mumba, Dieudonné; Mpanya, Alain; Kambo, Charles; Ngolo, Digas; Mutombo, Wilfried; Hugonnet, Stéphane; Rembry, Sandra; Tipple, Craig; Inocencio Da Luz, Raquel; Snijders, Rian; Vander Kelen, Catiane; Rogé, Stijn; Van Reet, Nick; Tarral, Antoine; Verlé, Paul; Hasker, Epco
发表日期：2025
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Efficacy and safety of acoziborole in patients with human African trypanosomiasis caused by Trypanosoma brucei gambiense: a multicentre, open-label, single-arm, phase 2/3 trial

评估阿可唑硼罗治疗由冈比亚锥虫引起的非洲锥虫病患者的疗效和安全性：一项多中心、开放标签、单臂 II/III 期试验

期刊:Lancet Infectious Diseases
影响因子:31
doi:10.1016/S1473-3099(22)00660-0
Betu Kumeso, Victor Kande; Kalonji, Wilfried Mutombo; Rembry, Sandra; Valverde Mordt, Olaf; Ngolo Tete, Digas; Prêtre, Adeline; Delhomme, Sophie; Ilunga Wa Kyhi, Médard; Camara, Mamadou; Catusse, Julie; Schneitter, Stefan; Nusbaumer, Morgane; Mwamba Miaka, Erick; Mahenzi Mbembo, Hélène; Makaya Mayawula, Joseph; Layba Camara, Mariame; Akwaso Massa, Félix; Kaninda Badibabi, Lewis; Kasongo Bonama, Augustin; Kavunga Lukula, Papy; Mutanda Kalonji, Sylvain; Mariero Philemon, Phyll; Mokilifi Nganyonyi, Ricardo; Embana Mankiara, Hugues; Asuka Akongo Nguba, André; Kobo Muanza, Vincent; Mulenge Nasandhel, Ernest; Fifi Nzeza Bambuwu, Aimée; Scherrer, Bruno; Strub-Wourgaft, Nathalie; Tarral, Antoine
发表日期：2023
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Determination of the Optimal Single Dose Treatment for Acoziborole, a Novel Drug for the Treatment of Human African Trypanosomiasis: First-in-Human Study

确定治疗人类非洲锥虫病的新型药物阿可唑硼罗的最佳单次剂量：首次人体研究

期刊:Clinical Pharmacokinetics
影响因子:4
doi:10.1007/s40262-023-01216-8
Tarral, Antoine; Hovsepian, Lionel; Duvauchelle, Thierry; Donazzolo, Yves; Latreille, Mathilde; Felices, Mathieu; Gualano, Virginie; Delhomme, Sophie; Valverde Mordt, Olaf; Blesson, Severine; Voiriot, Pascal; Strub-Wourgaft, Nathalie
Human
发表日期：2023
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Safety and efficacy of oral fexinidazole in children with gambiense human African trypanosomiasis: a multicentre, single-arm, open-label, phase 2-3 trial

口服非西硝唑治疗冈比亚锥虫病患儿的安全性和有效性：一项多中心、单臂、开放标签的 II/III 期试验

期刊:Lancet Global Health
影响因子:18
doi:10.1016/S2214-109X(22)00338-2
Kande Betu Kumesu, Victor; Mutombo Kalonji, Wilfried; Bardonneau, Clélia; Valverde Mordt, Olaf; Ngolo Tete, Digas; Blesson, Séverine; Simon, François; Delhomme, Sophie; Bernhard, Sonja; Nganzobo Ngima, Pathou; Mahenzi Mbembo, Hélène; Fina Lubaki, Jean-Pierre; Lumeya Vuvu, Steven; Kuziena Mindele, Willy; Ilunga Wa Kyhi, Médard; Mandula Mokenge, Guylain; Kaninda Badibabi, Lewis; Kasongo Bonama, Augustin; Kavunga Lukula, Papy; Lumbala, Crispin; Scherrer, Bruno; Strub-Wourgaft, Nathalie; Tarral, Antoine
发表日期：2022
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Trypanosome spliced leader RNA for diagnosis of acoziborole treatment outcome in gambiense human African trypanosomiasis: A longitudinal follow-up study

利用锥虫剪接前导RNA诊断冈比亚锥虫病患者阿科齐博罗治疗效果：一项纵向随访研究

期刊:EBioMedicine
影响因子:10.8
doi:10.1016/j.ebiom.2022.104376
Ngay Lukusa, Ipos; Van Reet, Nick; Mumba Ngoyi, Dieudonné; Mwamba Miaka, Erick; Masumu, Justin; Patient Pyana, Pati; Mutombo, Wilfried; Ngolo, Digas; Kobo, Vincent; Akwaso, Felix; Ilunga, Médard; Kaninda, Lewis; Mutanda, Sylvain; Mpoyi Muamba, Dieudonné; Valverde Mordt, Olaf; Tarral, Antoine; Rembry, Sandra; Büscher, Philippe; Lejon, Veerle
发表日期：2022
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Development and Introduction of Fexinidazole into the Global Human African Trypanosomiasis Program

将非西硝唑纳入全球人类非洲锥虫病防治计划

期刊:American Journal of Tropical Medicine and Hygiene
影响因子:1.6
doi:10.4269/ajtmh.21-1176
Valverde Mordt, Olaf; Tarral, Antoine; Strub-Wourgaft, Nathalie
Human
发表日期：2022
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Trypanosome SL-RNA detection in blood and cerebrospinal fluid to demonstrate active gambiense human African trypanosomiasis infection

在血液和脑脊液中检测锥虫SL-RNA，以证实冈比亚锥虫感染活跃。

期刊:PLoS Neglected Tropical Diseases
影响因子:3.4
doi:10.1371/journal.pntd.0009739
Ngay Lukusa, Ipos; Van Reet, Nick; Mumba Ngoyi, Dieudonné; Miaka, Erick Mwamba; Masumu, Justin; Patient Pyana, Pati; Mutombo, Wilfried; Ngolo, Digas; Kobo, Vincent; Akwaso, Felix; Ilunga, Médard; Kaninda, Lewis; Mutanda, Sylvain; Muamba, Dieudonné Mpoyi; Valverde Mordt, Olaf; Tarral, Antoine; Rembry, Sandra; Büscher, Philippe; Lejon, Veerle
炎症/感染
神经科学
发表日期：2021
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Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases

无症状感染对某些热带寄生虫病自然史的影响

期刊:Seminars in Immunopathology
影响因子:9.2
doi:10.1007/s00281-020-00796-y
Alvar, Jorge; Alves, Fabiana; Bucheton, Bruno; Burrows, Louise; Büscher, Philippe; Carrillo, Eugenia; Felger, Ingrid; Hübner, Marc P; Moreno, Javier; Pinazo, Maria-Jesus; Ribeiro, Isabela; Sosa-Estani, Sergio; Specht, Sabine; Tarral, Antoine; Wourgaft, Nathalie Strub; Bilbe, Graeme
炎症/感染
微生物学
发表日期：2020
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Pharmacokinetic-Pharmacodynamic Assessment of the Hepatic and Bone Marrow Toxicities of the New Trypanoside Fexinidazole

新型锥虫苷类药物非西硝唑的肝脏和骨髓毒性的药代动力学-药效学评估

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.02515-18
Watson, James A; Strub-Wourgraft, Nathalie; Tarral, Antoine; Ribeiro, Isabela; Tarning, Joel; White, Nicholas J
毒理研究
发表日期：2019
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